QTRT2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: QTRT2_HUMAN
• UniProt AC: Q9H974
• Protein Name: Queuine tRNA-ribosyltransferase accessory subunit 2 {ECO:0000255|HAMAP-Rule:MF_03043}
• Gene Name: QTRT2 {ECO:0000255|HAMAP-Rule:MF_03043}
• Organism: Homo sapiens (Human).
• Sequence Length: 415
• Subcellular Localization: Cytoplasm . Mitochondrion outer membrane ; Peripheral membrane protein ; Cytoplasmic side . May associate with the mitochondrion outer membrane.
• Protein Description: Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)..
• Protein Sequence: MKLSLTKVVNGCRLGKIKNLGKTGDHTMDIPGCLLYTKTGSAPHLTHHTLHNIHGVPAMAQLTLSSLAEHHEVLTEYKEGVGKFIGMPESLLYCSLHDPVSPCPAGYVTNKSVSVWSVAGRVEMTVSKFMAIQKALQPDWFQCLSDGEVSCKEATSIKRVRKSVDRSLLFLDNCLRLQEESEVLQKSVIIGVIEGGDVMEERLRSARETAKRPVGGFLLDGFQGNPTTLEARLRLLSSVTAELPEDKPRLISGVSRPDEVLECIERGVDLFESFFPYQVTERGCALTFSFDYQPNPEETLLQQNGTQEEIKCMDQIKKIETTGCNQEITSFEINLKEKKYQEDFNPLVRGCSCYCCKNHTRAYIHHLLVTNELLAGVLLMMHNFEHYFGFFHYIREALKSDKLAQLKELIHRQAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Methylation	------MKLSLTKVV ------CCCCCCEEE		115976007
4	Phosphorylation	----MKLSLTKVVNG ----CCCCCCEEECC		24719451
7	Ubiquitination	-MKLSLTKVVNGCRL -CCCCCCEEECCEEE		27667366
19	Ubiquitination	CRLGKIKNLGKTGDH EEECCCCCCCCCCCC		27667366
29	Ubiquitination	KTGDHTMDIPGCLLY CCCCCCCCCCCEEEE		29967540
35	Ubiquitination	MDIPGCLLYTKTGSA CCCCCEEEEECCCCC		27667366
46	Ubiquitination	TGSAPHLTHHTLHNI CCCCCCCCHHHHCCC		29967540
52	Ubiquitination	LTHHTLHNIHGVPAM CCHHHHCCCCCCCHH		27667366
63	Ubiquitination	VPAMAQLTLSSLAEH CCHHHHCHHHHHHHH		21963094
72	Ubiquitination	SSLAEHHEVLTEYKE HHHHHHHHHHHHHHH		27667366
80	Ubiquitination	VLTEYKEGVGKFIGM HHHHHHHCCHHHCCC		21963094
83	Ubiquitination	EYKEGVGKFIGMPES HHHHCCHHHCCCCHH		21906983
88	Ubiquitination	VGKFIGMPESLLYCS CHHHCCCCHHHEEEC		21890473
88	Ubiquitination	VGKFIGMPESLLYCS CHHHCCCCHHHEEEC		21890473
95	Ubiquitination	PESLLYCSLHDPVSP CHHHEEECCCCCCCC		29967540
100	Ubiquitination	YCSLHDPVSPCPAGY EECCCCCCCCCCCCE		21963094
105	Ubiquitination	DPVSPCPAGYVTNKS CCCCCCCCCEECCCC		21890473
105	Ubiquitination	DPVSPCPAGYVTNKS CCCCCCCCCEECCCC		21890473
124	Ubiquitination	SVAGRVEMTVSKFMA EECEEEEEEHHHHHH		24816145
125	Ubiquitination	VAGRVEMTVSKFMAI ECEEEEEEHHHHHHH		21890473
128	Ubiquitination	RVEMTVSKFMAIQKA EEEEEHHHHHHHHHH		-
134	Ubiquitination	SKFMAIQKALQPDWF HHHHHHHHHHCCCHH		-
141	Ubiquitination	KALQPDWFQCLSDGE HHHCCCHHHHCCCCC		24816145
152	Ubiquitination	SDGEVSCKEATSIKR CCCCEECCCCCCHHH		29967540
158	Ubiquitination	CKEATSIKRVRKSVD CCCCCCHHHHHHHHH		27667366
161	Ubiquitination	ATSIKRVRKSVDRSL CCCHHHHHHHHHHHH		24816145
164	Ubiquitination	IKRVRKSVDRSLLFL HHHHHHHHHHHHHHH		29967540
170	Ubiquitination	SVDRSLLFLDNCLRL HHHHHHHHHHHHHHH		27667366
186	Ubiquitination	EESEVLQKSVIIGVI HHHHHHHHHHEEEEE		21963094
195	Ubiquitination	VIIGVIEGGDVMEER HEEEEEECCHHHHHH		29967540
198	Ubiquitination	GVIEGGDVMEERLRS EEEECCHHHHHHHHH		21963094
211	Ubiquitination	RSARETAKRPVGGFL HHHHHHHCCCCCEEE		21906983
212	Ubiquitination	SARETAKRPVGGFLL HHHHHHCCCCCEEEC		29967540
213	Ubiquitination	ARETAKRPVGGFLLD HHHHHCCCCCEEECC		29967540
216	Ubiquitination	TAKRPVGGFLLDGFQ HHCCCCCEEECCCCC		27667366
223	Ubiquitination	GFLLDGFQGNPTTLE EEECCCCCCCCCCHH		21890473
230	Ubiquitination	QGNPTTLEARLRLLS CCCCCCHHHHHHHHH		29967540
233	Ubiquitination	PTTLEARLRLLSSVT CCCHHHHHHHHHHHC		27667366
237	Phosphorylation	EARLRLLSSVTAELP HHHHHHHHHHCCCCC		29255136
238	Phosphorylation	ARLRLLSSVTAELPE HHHHHHHHHCCCCCC		29255136
240	Phosphorylation	LRLLSSVTAELPEDK HHHHHHHCCCCCCCC		29255136
247	Ubiquitination	TAELPEDKPRLISGV CCCCCCCCCCEECCC		21906983
253	Ubiquitination	DKPRLISGVSRPDEV CCCCEECCCCCHHHH		27667366
259	Ubiquitination	SGVSRPDEVLECIER CCCCCHHHHHHHHHH		24816145
279	Ubiquitination	ESFFPYQVTERGCAL HHHCCEEECCCCEEE		29967540
296	Ubiquitination	SFDYQPNPEETLLQQ EECCCCCHHHHHHHC		29967540
318	Ubiquitination	KCMDQIKKIETTGCN HHHHHHEEEEECCCC		29967540
330	Ubiquitination	GCNQEITSFEINLKE CCCCEEEEEEEECCC		29967540
336	Ubiquitination	TSFEINLKEKKYQED EEEEEECCCCHHHHC		29967540
339	Ubiquitination	EINLKEKKYQEDFNP EEECCCCHHHHCCCH		21906983
348	Ubiquitination	QEDFNPLVRGCSCYC HHCCCHHHCCCEEEE		29967540
351	Ubiquitination	FNPLVRGCSCYCCKN CCHHHCCCEEEECCC		27667366
400	Phosphorylation	YIREALKSDKLAQLK HHHHHHHHCHHHHHH		20068231
402	Ubiquitination	REALKSDKLAQLKEL HHHHHHCHHHHHHHH		21906983
407	Ubiquitination	SDKLAQLKELIHRQA HCHHHHHHHHHHHHC		21906983
414	Ubiquitination	KELIHRQAS------ HHHHHHHCC------		29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of QTRT2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of QTRT2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of QTRT2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WAC_HUMAN	WAC	physical	22939629
TGT_HUMAN	QTRT1	physical	26344197
MARC1_HUMAN	MARC1	physical	27173435
AGM1_HUMAN	PGM3	physical	27173435
BDH_HUMAN	BDH1	physical	27173435

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.