LDB3_HUMAN - dbPTM
LDB3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LDB3_HUMAN
UniProt AC O75112
Protein Name LIM domain-binding protein 3
Gene Name LDB3 {ECO:0000312|HGNC:HGNC:15710}
Organism Homo sapiens (Human).
Sequence Length 727
Subcellular Localization Cytoplasm, perinuclear region . Cell projection, pseudopodium . Cytoplasm, cytoskeleton . Cytoplasm, myofibril, sarcomere, Z line . Localized to the cytoplasm around nuclei and pseudopodia of undifferentiated cells and detected throughout the myotube
Protein Description May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton..
Protein Sequence MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMTHLEAQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPHQKDPALDTNGSLVAPSPSPEARASPGTPGTPELRPTFSPAFSRPSAFSSLAEASDPGPPRASLRAKTSPEGARDLLGPKALPGSSQPRQYNNPIGLYSAETLREMAQMYQMSLRGKASGVGLPGGSLPIKDLAVDSASPVYQAVIKSQNKPEDEADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRRSSTPIEHAPVCTSQATTPLLPASAQPPAAASPSAASPPLATAAAHTAIASASTTAPASSPADSPRPQASSYSPAVAASSAPATHTSYSEGPAAPAPKPRVVTTASIRPSVYQPVPASTYSPSPGANYSPTPYTPSPAPAYTPSPAPAYTPSPVPTYTPSPAPAYTPSPAPNYNPAPSVAYSGGPAEPASRPPWVTDDSFSQKFAPGKSTTSISKQTLPRGGPAYTPAGPQVPPLARGTVQRAERFPASSRTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKKHAHTINL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSYSVTLTG
------CCEEEEEEC		26.56-
21SumoylationGFRLQGGKDFNMPLT
CEEECCCCCCCCCEE		67.00-
44PhosphorylationKAAQSQLSQGDLVVA
HHHHHHCCCCCEEEE		25.2026437602
71PhosphorylationEAQNKIKSASYNLSL
HHHHHHHHCEEEEEE		26.3926437602
73PhosphorylationQNKIKSASYNLSLTL
HHHHHHCEEEEEEEE		22.9626437602
74PhosphorylationNKIKSASYNLSLTLQ
HHHHHCEEEEEEEEC		21.6029496907
83PhosphorylationLSLTLQKSKRPIPIS
EEEEECCCCCCCCCC		22.4226437602
90PhosphorylationSKRPIPISTTAPPVQ
CCCCCCCCCCCCCCC		17.8526437602
91PhosphorylationKRPIPISTTAPPVQT
CCCCCCCCCCCCCCC		27.9126437602
92PhosphorylationRPIPISTTAPPVQTP
CCCCCCCCCCCCCCC		30.3123312004
98PhosphorylationTTAPPVQTPLPVIPH
CCCCCCCCCCCCCCC		27.3323312004
112 (in isoform 6)Phosphorylation-39.9919764811
112 (in isoform 2)Phosphorylation-39.9919764811
113PhosphorylationQKDPALDTNGSLVAP
CCCCCCCCCCCEECC		42.1826657352
116PhosphorylationPALDTNGSLVAPSPS
CCCCCCCCEECCCCC		23.03-
118 (in isoform 2)Phosphorylation-8.68-
118 (in isoform 6)Phosphorylation-8.68-
121PhosphorylationNGSLVAPSPSPEARA
CCCEECCCCCHHHCC		28.4226657352
123PhosphorylationSLVAPSPSPEARASP
CEECCCCCHHHCCCC		39.4426657352
125 (in isoform 2)Phosphorylation-55.9426437602
125 (in isoform 6)Phosphorylation-55.9426437602
129PhosphorylationPSPEARASPGTPGTP
CCHHHCCCCCCCCCC		20.5026657352
132PhosphorylationEARASPGTPGTPELR
HHCCCCCCCCCCCCC		23.1726657352
134 (in isoform 2)Phosphorylation-54.4626437602
134 (in isoform 6)Phosphorylation-54.4626437602
135PhosphorylationASPGTPGTPELRPTF
CCCCCCCCCCCCCCC		18.1326657352
141PhosphorylationGTPELRPTFSPAFSR
CCCCCCCCCCCCCCC		30.2523312004
143PhosphorylationPELRPTFSPAFSRPS
CCCCCCCCCCCCCCH		20.1426657352
147PhosphorylationPTFSPAFSRPSAFSS
CCCCCCCCCCHHHHH		45.4423312004
156 (in isoform 6)Phosphorylation-16.5626437602
156 (in isoform 2)Phosphorylation-16.5626437602
171UbiquitinationPRASLRAKTSPEGAR
CCCHHEECCCCCCHH		43.00-
172PhosphorylationRASLRAKTSPEGARD
CCHHEECCCCCCHHH		48.8323532336
173PhosphorylationASLRAKTSPEGARDL
CHHEECCCCCCHHHH		21.9026437602
179 (in isoform 6)Phosphorylation-45.7922673903
179 (in isoform 2)Phosphorylation-45.7922673903
182 (in isoform 2)Phosphorylation-29.0322673903
182 (in isoform 6)Phosphorylation-29.0322673903
184 (in isoform 6)Phosphorylation-61.8422673903
184 (in isoform 2)Phosphorylation-61.8422673903
202PhosphorylationYNNPIGLYSAETLRE
CCCCCCCCCHHHHHH		10.71-
217PhosphorylationMAQMYQMSLRGKASG
HHHHHHHHHHCCCCC		10.21-
219MethylationQMYQMSLRGKASGVG
HHHHHHHHCCCCCCC		36.94-
223PhosphorylationMSLRGKASGVGLPGG
HHHHCCCCCCCCCCC		37.18-
240 (in isoform 7)Phosphorylation-32.6426437602
240 (in isoform 4)Phosphorylation-32.6426437602
241PhosphorylationIKDLAVDSASPVYQA
HHHHEECCCCHHHHH		24.8527732954
243PhosphorylationDLAVDSASPVYQAVI
HHEECCCCHHHHHHH		20.8926657352
246PhosphorylationVDSASPVYQAVIKSQ
ECCCCHHHHHHHHCC		8.3027732954
249 (in isoform 4)Phosphorylation-3.1426437602
249 (in isoform 7)Phosphorylation-3.1426437602
251 (in isoform 2)Phosphorylation-39.1126437602
257 (in isoform 6)Phosphorylation-70.8226437602
259 (in isoform 2)Phosphorylation-57.2526437602
261 (in isoform 6)Phosphorylation-50.3426437602
267PhosphorylationADEWARRSSNLQSRS
HHHHHHHHHHHHHHH		20.3026657352
268PhosphorylationDEWARRSSNLQSRSF
HHHHHHHHHHHHHHH		39.4824114839
271 (in isoform 7)Phosphorylation-40.8426437602
271 (in isoform 4)Phosphorylation-40.8426437602
272PhosphorylationRRSSNLQSRSFRILA
HHHHHHHHHHHHHHH		32.8124114839
275 (in isoform 6)Phosphorylation-5.6820639409
282PhosphorylationFRILAQMTGTEFMQD
HHHHHHHHCCCHHCC		28.9526437602
283 (in isoform 6)Phosphorylation-20.2226437602
294 (in isoform 7)Phosphorylation-12.3422673903
294 (in isoform 4)Phosphorylation-12.3422673903
297 (in isoform 7)Phosphorylation-35.4922673903
297 (in isoform 4)Phosphorylation-35.4922673903
299 (in isoform 4)Phosphorylation-36.0722673903
299 (in isoform 7)Phosphorylation-36.0722673903
304 (in isoform 5)Phosphorylation-35.7326437602
308 (in isoform 5)Phosphorylation-2.7026437602
322 (in isoform 5)Phosphorylation-41.8520639409
330 (in isoform 5)Phosphorylation-33.6926437602
366 (in isoform 7)Phosphorylation-25.2626437602
372 (in isoform 4)Phosphorylation-5.3326437602
374 (in isoform 7)Phosphorylation-9.4526437602
375PhosphorylationYSPAVAASSAPATHT
CCCCHHHCCCCCCCC		19.80-
376 (in isoform 4)Phosphorylation-33.2826437602
390 (in isoform 4)Phosphorylation-12.1520639409
398 (in isoform 4)Phosphorylation-4.0926437602
505PhosphorylationQKFAPGKSTTSISKQ
CCCCCCCCCCCCCCC		42.7226437602
508PhosphorylationAPGKSTTSISKQTLP
CCCCCCCCCCCCCCC		25.5926437602
510PhosphorylationGKSTTSISKQTLPRG
CCCCCCCCCCCCCCC		20.6226437602
513PhosphorylationTTSISKQTLPRGGPA
CCCCCCCCCCCCCCC		42.3326437602
516MethylationISKQTLPRGGPAYTP
CCCCCCCCCCCCCCC		66.85-
521PhosphorylationLPRGGPAYTPAGPQV
CCCCCCCCCCCCCCC		19.18-
533MethylationPQVPPLARGTVQRAE
CCCCCCCCCHHHHHH		49.34-
548PhosphorylationRFPASSRTPLCGHCN
CCCCCCCCCCCCCCC		23.6626437602
579PhosphorylationPEEFTCAYCKTSLAD
HHHCCCCCCCCCHHH		9.16-
656PhosphorylationHMEDGEPYCEKDYIN
ECCCCCCCCCHHHEE		14.67-
661PhosphorylationEPYCEKDYINLFSTK
CCCCCHHHEEEECCC		11.63-
666PhosphorylationKDYINLFSTKCHGCD
HHHEEEECCCCCCCC		30.0729759185
667PhosphorylationDYINLFSTKCHGCDF
HHEEEECCCCCCCCC		30.2929759185
712AcetylationEGQPFYSKKDRPLCK
CCCCCCCCCCCCCHH		47.5230589853
713AcetylationGQPFYSKKDRPLCKK
CCCCCCCCCCCCHHH		53.6930589859
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LDB3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LDB3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LDB3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ACTN2_HUMANACTN2physical
10427098
RHOA_HUMANRHOAphysical
26186194
NPC2_HUMANNPC2physical
26186194
NPC2_HUMANNPC2physical
28514442
RHOA_HUMANRHOAphysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
601493Cardiomyopathy, dilated 1C, with or without left ventricular non-compaction (CMD1C)
601493Left ventricular non-compaction 3 (LVNC3)
609452Myopathy, myofibrillar, 4 (MFM4)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LDB3_HUMAN

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Related Literatures of Post-Translational Modification

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