APOC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: APOC2_HUMAN
• UniProt AC: P02655
• Protein Name: Apolipoprotein C-II
• Gene Name: APOC2
• Organism: Homo sapiens (Human).
• Sequence Length: 101
• Subcellular Localization: Secreted .
• Protein Description: Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL..
• Protein Sequence: MGTRLLPALFLVLLVLGFEVQGTQQPQQDEMPSPTFLTQVKESLSSYWESAKTAAQNLYEKTYLPAVDEKLRDLYSKSTAAMSTYTGIFTDQVLSVLKGEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Sulfoxidation	GTRLLPALFLVLLVL CCCHHHHHHHHHHHH	3.01	18729385
23	O-linked_Glycosylation	LGFEVQGTQQPQQDE HCCCCCCCCCCCCCC	13.62	OGP
33	O-linked_Glycosylation	PQQDEMPSPTFLTQV CCCCCCCCCCHHHHH	34.95	OGP
35	O-linked_Glycosylation	QDEMPSPTFLTQVKE CCCCCCCCHHHHHHH	35.30	OGP
43	O-linked_Glycosylation	FLTQVKESLSSYWES HHHHHHHHHHHHHHH	28.03	OGP
43	Phosphorylation	FLTQVKESLSSYWES HHHHHHHHHHHHHHH	28.03	22461510
45	O-linked_Glycosylation	TQVKESLSSYWESAK HHHHHHHHHHHHHHH	30.57	OGP
46	O-linked_Glycosylation	QVKESLSSYWESAKT HHHHHHHHHHHHHHH	39.29	OGP
47	Phosphorylation	VKESLSSYWESAKTA HHHHHHHHHHHHHHH	15.15	22461510
50	O-linked_Glycosylation	SLSSYWESAKTAAQN HHHHHHHHHHHHHHH	22.40	OGP
50	Phosphorylation	SLSSYWESAKTAAQN HHHHHHHHHHHHHHH	22.40	22461510
53	O-linked_Glycosylation	SYWESAKTAAQNLYE HHHHHHHHHHHHHHH	27.26	OGP
60	Sulfoxidation	TAAQNLYEKTYLPAV HHHHHHHHHHHHHHH	41.93	18729385
75	Phosphorylation	DEKLRDLYSKSTAAM HHHHHHHHCHHHCHH	20.52	23532336
86	Phosphorylation	TAAMSTYTGIFTDQV HCHHHHHHCCCHHHH	24.72	23532336
86	O-linked_Glycosylation	TAAMSTYTGIFTDQV HCHHHHHHCCCHHHH	24.72	OGP
98	Ubiquitination	DQVLSVLKGEE---- HHHHHHHCCCC----	63.22	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of APOC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of APOC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of APOC2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LIPL_BOVIN	LPL	physical	10727238
CRYAB_HUMAN	CRYAB	physical	23159935

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 207750: Hyperlipoproteinemia 1B (HLPP1B)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.