| UniProt ID | LIPL_BOVIN | |
|---|---|---|
| UniProt AC | P11151 | |
| Protein Name | Lipoprotein lipase | |
| Gene Name | LPL | |
| Organism | Bos taurus (Bovine). | |
| Sequence Length | 478 | |
| Subcellular Localization |
Cell membrane Lipid-anchor, GPI-anchor. Secreted. Locates to the plasma membrane of microvilli of hepatocytes with triacyl-glycerol-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles. |
|
| Protein Description | The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium.. | |
| Protein Sequence | MESKALLLLALSVCLQSLTVSRGGLVAADRITGGKDFRDIESKFALRTPEDTAEDTCHLIPGVTESVANCHFNHSSKTFVVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQQHYPVSAGYTKLVGQDVAKFMNWMADEFNYPLGNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEALRVIAERGLGDVDQLVKCSHERSVHLFIDSLLNEENPSKAYRCNSKEAFEKGLCLSCRKNRCNNMGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESNTYTNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLLYTEVDIGELLMLKLKWISDSYFSWSNWWSSPGFDIGKIRVKAGETQKKVIFCSREKMSYLQKGKSPVIFVKCHDKSLNRKSG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 73 | N-linked_Glycosylation | SVANCHFNHSSKTFV HHEECEECCCCCEEE | 15.51 | 2674142 | |
| 103 | Nitration | PKLVAALYKREPDSN HHHHHHHHHCCCCCC | 11.85 | - | |
| 124 | Nitrated tyrosine | LSRAQQHYPVSAGYT HHHHHHHCCCCCCCH | 10.86 | - | |
| 124 | Nitration | LSRAQQHYPVSAGYT HHHHHHHCCCCCCCH | 10.86 | - | |
| 130 | Nitration | HYPVSAGYTKLVGQD HCCCCCCCHHHHCHH | 10.62 | - | |
| 194 | Nitrated tyrosine | PAGPNFEYAEAPSRL CCCCCCCCCCCCCCC | 12.95 | - | |
| 194 | Nitration | PAGPNFEYAEAPSRL CCCCCCCCCCCCCCC | 12.95 | - | |
| 287 | N-linked_Glycosylation | DSLLNEENPSKAYRC HHHHCCCCCCCCCCC | 39.71 | - | |
| 318 | Nitration | NRCNNMGYEINKVRA CCCCCCCHHHHHHHH | 11.67 | - | |
| 341 | Nitration | KTRSQMPYKVFHYQV EEHHCCCCEEEEEEE | 17.91 | - | |
| 346 | Nitrated tyrosine | MPYKVFHYQVKIHFS CCCEEEEEEEEEEEC | 11.97 | - | |
| 346 | Nitration | MPYKVFHYQVKIHFS CCCEEEEEEEEEEEC | 11.97 | - | |
| 389 | N-linked_Glycosylation | TLPEVSTNKTYSFLL CCCCCCCCCEEEEEE | 27.45 | 2674142 | |
| 455 | Nitration | CSREKMSYLQKGKSP ECHHHHHHHHCCCCC | 15.06 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LIPL_BOVIN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LIPL_BOVIN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LIPL_BOVIN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of LIPL_BOVIN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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