| UniProt ID | CLCA2_HUMAN | |
|---|---|---|
| UniProt AC | Q9UQC9 | |
| Protein Name | Calcium-activated chloride channel regulator 2 | |
| Gene Name | CLCA2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 943 | |
| Subcellular Localization |
Cell membrane Single-pass type I membrane protein. Basal cell membrane Single-pass type I membrane protein. Cell junction. Calcium-activated chloride channel regulator 2, 109 kDa form: Secreted. Remains associated to the 35 kDa form until an unide |
|
| Protein Description | Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4.. | |
| Protein Sequence | MTQRSIAGPICNLKFVTLLVALSSELPFLGAGVQLQDNGYNGLLIAINPQVPENQNLISNIKEMITEASFYLFNATKRRVFFRNIKILIPATWKANNNSKIKQESYEKANVIVTDWYGAHGDDPYTLQYRGCGKEGKYIHFTPNFLLNDNLTAGYGSRGRVFVHEWAHLRWGVFDEYNNDKPFYINGQNQIKVTRCSSDITGIFVCEKGPCPQENCIISKLFKEGCTFIYNSTQNATASIMFMQSLSSVVEFCNASTHNQEAPNLQNQMCSLRSAWDVITDSADFHHSFPMNGTELPPPPTFSLVQAGDKVVCLVLDVSSKMAEADRLLQLQQAAEFYLMQIVEIHTFVGIASFDSKGEIRAQLHQINSNDDRKLLVSYLPTTVSAKTDISICSGLKKGFEVVEKLNGKAYGSVMILVTSGDDKLLGNCLPTVLSSGSTIHSIALGSSAAPNLEELSRLTGGLKFFVPDISNSNSMIDAFSRISSGTGDIFQQHIQLESTGENVKPHHQLKNTVTVDNTVGNDTMFLVTWQASGPPEIILFDPDGRKYYTNNFITNLTFRTASLWIPGTAKPGHWTYTLNNTHHSLQALKVTVTSRASNSAVPPATVEAFVERDSLHFPHPVMIYANVKQGFYPILNATVTATVEPETGDPVTLRLLDDGAGADVIKNDGIYSRYFFSFAANGRYSLKVHVNHSPSISTPAHSIPGSHAMYVPGYTANGNIQMNAPRKSVGRNEEERKWGFSRVSSGGSFSVLGVPAGPHPDVFPPCKIIDLEAVKVEEELTLSWTAPGEDFDQGQATSYEIRMSKSLQNIQDDFNNAILVNTSKRNPQQAGIREIFTFSPQISTNGPEHQPNGETHESHRIYVAIRAMDRNSLQSAVSNIAQAPLFIPPNSDPVPARDYLILKGVLTAMGLIGIICLIIVVTHHTLSRKKRADKKENGTKLL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 74 | N-linked_Glycosylation | EASFYLFNATKRRVF HHHHHHHHHCCCEEE | 44.07 | UniProtKB CARBOHYD | |
| 76 | Phosphorylation | SFYLFNATKRRVFFR HHHHHHHCCCEEEEE | 26.62 | - | |
| 150 | N-linked_Glycosylation | PNFLLNDNLTAGYGS CCEEECCCCCCCCCC | 37.91 | UniProtKB CARBOHYD | |
| 155 | Phosphorylation | NDNLTAGYGSRGRVF CCCCCCCCCCCCCEE | 14.95 | - | |
| 157 | Phosphorylation | NLTAGYGSRGRVFVH CCCCCCCCCCCEEEE | 24.07 | - | |
| 231 | N-linked_Glycosylation | EGCTFIYNSTQNATA CCCEEEEECCCCHHH | 33.49 | UniProtKB CARBOHYD | |
| 379 | Phosphorylation | DRKLLVSYLPTTVSA CHHEEEEECCCCCCC | 14.82 | 27273156 | |
| 385 | Phosphorylation | SYLPTTVSAKTDISI EECCCCCCCCCCHHH | 23.19 | 27273156 | |
| 388 | Phosphorylation | PTTVSAKTDISICSG CCCCCCCCCHHHCCC | 37.98 | 27273156 | |
| 394 | Phosphorylation | KTDISICSGLKKGFE CCCHHHCCCCCCCEE | 45.55 | 27273156 | |
| 522 | N-linked_Glycosylation | TVDNTVGNDTMFLVT EEECCCCCCEEEEEE | 36.92 | UniProtKB CARBOHYD | |
| 667 | Acetylation | GAGADVIKNDGIYSR CCCCCEEECCCCCEE | 49.16 | 11791615 | |
| 673 | Phosphorylation | IKNDGIYSRYFFSFA EECCCCCEEEEEEEE | 20.70 | 24719451 | |
| 686 | Phosphorylation | FAANGRYSLKVHVNH EEECCEEEEEEEECC | 21.98 | 24719451 | |
| 698 | Phosphorylation | VNHSPSISTPAHSIP ECCCCCCCCCCCCCC | 32.45 | 22210691 | |
| 715 | Phosphorylation | HAMYVPGYTANGNIQ CEEEECCEECCCCCC | 9.16 | 22210691 | |
| 822 | N-linked_Glycosylation | FNNAILVNTSKRNPQ HCCEEEEECCCCCHH | 34.88 | UniProtKB CARBOHYD | |
| 873 | Phosphorylation | IRAMDRNSLQSAVSN EEECCHHHHHHHHHH | 28.78 | - | |
| 876 | O-linked_Glycosylation | MDRNSLQSAVSNIAQ CCHHHHHHHHHHHHC | 35.61 | 29351928 | |
| 876 | Phosphorylation | MDRNSLQSAVSNIAQ CCHHHHHHHHHHHHC | 35.61 | - | |
| 879 | O-linked_Glycosylation | NSLQSAVSNIAQAPL HHHHHHHHHHHCCCC | 23.41 | 29351928 | |
| 935 | Acetylation | SRKKRADKKENGTKL HHHHHCCCCCCCCCC | 62.09 | 12432755 | |
| 936 | Acetylation | RKKRADKKENGTKLL HHHHCCCCCCCCCCC | 57.89 | 12432763 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CLCA2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CLCA2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CLCA2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RS21_HUMAN | RPS21 | physical | 26344197 | |
| NDC1_HUMAN | NDC1 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| D08275 | Niflumic acid (INN); Niflugel (TN) | |||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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