TPC11_HUMAN - dbPTM
TPC11_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TPC11_HUMAN
UniProt AC Q7Z392
Protein Name Trafficking protein particle complex subunit 11
Gene Name TRAPPC11
Organism Homo sapiens (Human).
Sequence Length 1133
Subcellular Localization Golgi apparatus . Golgi apparatus, cis-Golgi network.
Protein Description Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage..
Protein Sequence MSPTQWDFPVELCCRPMAFVTLTGLDVVYNAVHRAVWDAFCANRRADRVPISFKVLPGDHEYPKCRPKRTSYEWYIPKGILKTGWMNKHLNLVPALVVVFYELDWDEPQWKEKQSECATRVEIVRQSLQGRNTKVAVVLIQKKTPLPPGEDVIASERAAALCNACELSGKSLFVLPHTDHLVGYIIRLENAFYEHAQTYYYTEIRRVKSHKEFLNKTTHQLLFVRHQFKIAFFSELKQDTQNALKNYRTAYNLVHELRAHETNILEIKTMAGFINYKICRLCFQHNTPLDAIAQFRKHIDLCKKKIGSAELSFEHDAWMSKQFQAFGDLFDEAIKLGLTAIQTQNPGFYYQQAAYYAQERKQLAKTLCNHEASVMYPNPDPLETQTGVLDFYGQRSWRQGILSFDLSDPEKEKVGILAIQLKERNVVHSEIIITLLSNAVAQFKKYKCPRMKSHLMVQMGEEYYYAKDYTKALKLLDYVMCDYRSEGWWTLLTSVLTTALKCSYLMAQLKDYITYSLELLGRASTLKDDQKSRIEKNLINVLMNESPDPEPDCDILAVKTAQKLWADRISLAGSNIFTIGVQDFVPFVQCKAKFHAPSFHVDVPVQFDIYLKADCPHPIRFSKLCVSFNNQEYNQFCVIEEASKANEVLENLTQGKMCLVPGKTRKLLFKFVAKTEDVGKKIEITSVDLALGNETGRCVVLNWQGGGGDAASSQEALQAARSFKRRPKLPDNEVHWDSIIIQASTMIISRVPNISVHLLHEPPALTNEMYCLVVTVQSHEKTQIRDVKLTAGLKPGQDANLTQKTHVTLHGTELCDESYPALLTDIPVGDLHPGEQLEKMLYVRCGTVGSRMFLVYVSYLINTTVEEKEIVCKCHKDETVTIETVFPFDVAVKFVSTKFEHLERVYADIPFLLMTDLLSASPWALTIVSSELQLAPSMTTVDQLESQVDNVILQTGESASECFCLQCPSLGNIEGGVATGHYIISWKRTSAMENIPIITTVITLPHVIVENIPLHVNADLPSFGRVRESLPVKYHLQNKTDLVQDVEISVEPSDAFMFSGLKQIRLRILPGTEQEMLYNFYPLMAGYQQLPSLNINLLRFPNFTNQLLRRFIPTSIFVKPQGRLMDDTSIAAA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSPTQWDFP
------CCCCCCCCC		48.2125850435
4Phosphorylation----MSPTQWDFPVE
----CCCCCCCCCHH		52.1325850435
52PhosphorylationRADRVPISFKVLPGD
CCCCCCEEEEECCCC		16.9724719451
64UbiquitinationPGDHEYPKCRPKRTS
CCCCCCCCCCCCCCE		41.8129967540
70PhosphorylationPKCRPKRTSYEWYIP
CCCCCCCCEEEEEEC		41.6123403867
71PhosphorylationKCRPKRTSYEWYIPK
CCCCCCCEEEEEECC		25.7023403867
72PhosphorylationCRPKRTSYEWYIPKG
CCCCCCEEEEEECCC		15.1823403867
75PhosphorylationKRTSYEWYIPKGILK
CCCEEEEEECCCCHH		8.7323403867
81UbiquitinationWYIPKGILKTGWMNK
EEECCCCHHCCHHHH		5.7524816145
211UbiquitinationIRRVKSHKEFLNKTT
HHHHHHHHHHHCHHH		58.2029967540
217PhosphorylationHKEFLNKTTHQLLFV
HHHHHCHHHHHHHHH		28.5630622161
218PhosphorylationKEFLNKTTHQLLFVR
HHHHCHHHHHHHHHH		14.8330622161
237UbiquitinationIAFFSELKQDTQNAL
HHHHHHHHHHHHHHH		41.9232015554
242 (in isoform 2)Ubiquitination-49.7021890473
245AcetylationQDTQNALKNYRTAYN
HHHHHHHHHHHHHHH		49.9019608861
245UbiquitinationQDTQNALKNYRTAYN
HHHHHHHHHHHHHHH		49.9019608861
287PhosphorylationRLCFQHNTPLDAIAQ
HHHHHCCCCHHHHHH		24.09-
443UbiquitinationLSNAVAQFKKYKCPR
HHHHHHHHHHCCCHH		5.4822817900
445UbiquitinationNAVAQFKKYKCPRMK
HHHHHHHHCCCHHHC		51.75-
446PhosphorylationAVAQFKKYKCPRMKS
HHHHHHHCCCHHHCC		20.57-
448UbiquitinationAQFKKYKCPRMKSHL
HHHHHCCCHHHCCEE		2.0421890473
465PhosphorylationQMGEEYYYAKDYTKA
ECCCEEEECCCHHHH		13.28-
470PhosphorylationYYYAKDYTKALKLLD
EEECCCHHHHHHHHC		21.7029116813
478PhosphorylationKALKLLDYVMCDYRS
HHHHHHCHHCCCCCC		7.0529116813
483PhosphorylationLDYVMCDYRSEGWWT
HCHHCCCCCCCCHHH		15.8829116813
531UbiquitinationSTLKDDQKSRIEKNL
HCCCHHHHHHHHHHH		49.0124816145
656AcetylationLENLTQGKMCLVPGK
HHHHCCCCCCCCCCC		19.3425953088
656UbiquitinationLENLTQGKMCLVPGK
HHHHCCCCCCCCCCC		19.34-
666UbiquitinationLVPGKTRKLLFKFVA
CCCCCHHHHHHHHHC		55.57-
669UbiquitinationGKTRKLLFKFVAKTE
CCHHHHHHHHHCCCC		9.2821890473
670UbiquitinationKTRKLLFKFVAKTED
CHHHHHHHHHCCCCC		38.61-
674UbiquitinationLLFKFVAKTEDVGKK
HHHHHHCCCCCCCCE		47.33-
685PhosphorylationVGKKIEITSVDLALG
CCCEEEEEEEEEEEC		15.2023401153
686PhosphorylationGKKIEITSVDLALGN
CCEEEEEEEEEEECC		21.2123401153
695PhosphorylationDLALGNETGRCVVLN
EEEECCCCCCEEEEE		33.6523401153
794UbiquitinationVKLTAGLKPGQDANL
EEECCCCCCCCCCCC		46.3029967540
856PhosphorylationGSRMFLVYVSYLINT
CHHHHHHHHHHHHHC		5.94-
859PhosphorylationMFLVYVSYLINTTVE
HHHHHHHHHHHCCCC		11.10-
893UbiquitinationFPFDVAVKFVSTKFE
EEHHHHHHHHHCHHH		30.2522817900
898 (in isoform 1)Ubiquitination-41.0521890473
898 (in isoform 3)Ubiquitination-41.0521890473
898 (in isoform 4)Ubiquitination-41.0521890473
898UbiquitinationAVKFVSTKFEHLERV
HHHHHHCHHHHHHHH		41.0521890473
8982-HydroxyisobutyrylationAVKFVSTKFEHLERV
HHHHHHCHHHHHHHH		41.05-
1033UbiquitinationVRESLPVKYHLQNKT
CHHCCCCEEEECCCC		25.64-
1049PhosphorylationLVQDVEISVEPSDAF
CEEEEEEEECCCCCC		13.6129759185
1053PhosphorylationVEISVEPSDAFMFSG
EEEEECCCCCCHHCC		28.2329759185
1059PhosphorylationPSDAFMFSGLKQIRL
CCCCCHHCCCCEEEE		31.2829759185
1114PhosphorylationLLRRFIPTSIFVKPQ
HHHHHCCCCEEECCC		29.6424719451
1115PhosphorylationLRRFIPTSIFVKPQG
HHHHCCCCEEECCCC		14.5224719451
1119UbiquitinationIPTSIFVKPQGRLMD
CCCCEEECCCCCCCC		22.3723000965
1119 (in isoform 1)Ubiquitination-22.3721890473
1129PhosphorylationGRLMDDTSIAAA---
CCCCCCCCCCCC---		19.7524719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TPC11_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TPC11_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TPC11_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TPPC3_HUMANTRAPPC3physical
21525244
TPC12_HUMANTRAPPC12physical
21525244
TPC2L_HUMANTRAPPC2Lphysical
21525244
TPC2A_HUMANTRAPPC2physical
21525244
TPC2B_HUMANTRAPPC2physical
21525244
TPC11_HUMANTRAPPC11physical
21525244
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615356Limb-girdle muscular dystrophy 2S (LGMD2S)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TPC11_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-245, AND MASS SPECTROMETRY.

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