F71E2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: F71E2_HUMAN
• UniProt AC: Q8N5Q1
• Protein Name: Protein FAM71E2
• Gene Name: FAM71E2
• Organism: Homo sapiens (Human).
• Sequence Length: 922
• Protein Sequence: MIWLRNRRCLEPLQGTPKWVPVLGELQKTLQKGEYLPLRPLPMFESNFVQVTHQGGPVFVNHRTNRLAMGVAASLPGLVLPDILLIGQPAEDRDCSGLVLTRMIPLDLVHLCVHDLSAWRLKLRLVSGRQYYLALDAPDNEVGFLFHCWVRLINLLQEPAPTWTPRTTRTAPLDMPLAEAPASTWHLQDQPISRHAVRVAERNFPHKTVAAQRQRKAKALKRSFKSQAVGDSVPLIWSQLEHADVRKKPAEKKSHSDPRPDRTHTQIRLPEKTSITTWTIFSIISSTANQTQSSPKACTSASDEATGQGHVVESPSHCVSADSPDGFFLGSCSSLDPCLWHQDTEDLMDSGGSTLSSAASGLAPYPPAACLSTPYSSIPRGREKAGPMGSHQGPGPPPCQKAPSGLVTSCKAPFLVDQSQKLPAVPASSWKPPPGLAPPQKAPAASAPPRKAPAVPAPSQKAPAVPAPSQKAPAIPAPSRKASAASASPRKASAVPAPPQKTPPPSQKAPSVPTIPQKAVSPTAPKKKSLLLPAPSQKALPTSPTEYQMALSPPASRGKLPGDFDVLPTGIPGRAVLERSQSGGKPEPVVTVRTQETDVVEMTTQAKSPESPFTVTKKESKDILISQTKEVTLEAFRGQGKLEDWAHWAKLEERSPDLPGVRSKELEQRKRWVKAKELAVEGPSQEHSRPFSVEALTLTKLMITANSKEQPSKSALVSLPSWLLATPQASATSMMASVPSRPGQLSLLEGKPVVVREQPESHTWVKEGKRPWGEMKEQPWGEMKEPPWDPKGPPKVPFRSKPTSASLKREGISQAPIPLTASPWEDLRPSPLSETLISKMEATARASQQPKRVSQEPMRMPAQHPLATVGSSSEILLPMLLELETVRNTATKAEEIQEESGVLNLLPSLQHSQHSEWPDAGA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
162	Phosphorylation	LLQEPAPTWTPRTTR HHCCCCCCCCCCCCC	44.04	30622161
164	Phosphorylation	QEPAPTWTPRTTRTA CCCCCCCCCCCCCCC	12.84	30622161
167	Phosphorylation	APTWTPRTTRTAPLD CCCCCCCCCCCCCCC	23.10	30622161
168	Phosphorylation	PTWTPRTTRTAPLDM CCCCCCCCCCCCCCC	27.57	30622161
216	Acetylation	VAAQRQRKAKALKRS HHHHHHHHHHHHHHH	45.99	164329
221	Acetylation	QRKAKALKRSFKSQA HHHHHHHHHHHHHHH	51.35	164331
226	Phosphorylation	ALKRSFKSQAVGDSV HHHHHHHHHHHCCCH	22.74	30622161
232	Phosphorylation	KSQAVGDSVPLIWSQ HHHHHCCCHHCHHHH	21.50	30622161
238	Phosphorylation	DSVPLIWSQLEHADV CCHHCHHHHHHCCCC	20.21	30622161
419	Phosphorylation	APFLVDQSQKLPAVP CCEECCCCCCCCCCC	25.48	-
479	Phosphorylation	APAIPAPSRKASAAS CCCCCCCCCCCCCCC	48.82	23312004
486	Phosphorylation	SRKASAASASPRKAS CCCCCCCCCCCCCCC	29.06	-
488	Phosphorylation	KASAASASPRKASAV CCCCCCCCCCCCCCC	23.81	-
511	Phosphorylation	PPSQKAPSVPTIPQK CCCCCCCCCCCCCCC	45.66	30622161
521	Phosphorylation	TIPQKAVSPTAPKKK CCCCCCCCCCCCCCC	22.76	30622161
523	Phosphorylation	PQKAVSPTAPKKKSL CCCCCCCCCCCCCCC	48.35	30622161
529	Phosphorylation	PTAPKKKSLLLPAPS CCCCCCCCCCCCCCC	32.88	25693802
536	Phosphorylation	SLLLPAPSQKALPTS CCCCCCCCCCCCCCC	46.55	25693802
542	Phosphorylation	PSQKALPTSPTEYQM CCCCCCCCCCCCCHH	48.46	25693802
543	Phosphorylation	SQKALPTSPTEYQMA CCCCCCCCCCCCHHH	28.08	25693802
545	Phosphorylation	KALPTSPTEYQMALS CCCCCCCCCCHHHHC	47.28	25693802
547	Phosphorylation	LPTSPTEYQMALSPP CCCCCCCCHHHHCCC	13.18	25693802
552	Phosphorylation	TEYQMALSPPASRGK CCCHHHHCCCHHHCC	21.21	25693802
556	Phosphorylation	MALSPPASRGKLPGD HHHCCCHHHCCCCCC	47.54	25693802
569	Phosphorylation	GDFDVLPTGIPGRAV CCCCCCCCCCCCHHH	43.51	28555341
580	Phosphorylation	GRAVLERSQSGGKPE CHHHHHHHCCCCCCC	21.23	30622161
582	Phosphorylation	AVLERSQSGGKPEPV HHHHHHCCCCCCCCE	51.24	30622161
597	Phosphorylation	VTVRTQETDVVEMTT EEEEECCCCEEEEEC	25.03	22468782
603	Phosphorylation	ETDVVEMTTQAKSPE CCCEEEEECCCCCCC	11.40	25159151
604	Phosphorylation	TDVVEMTTQAKSPES CCEEEEECCCCCCCC	25.81	25627689
608	Phosphorylation	EMTTQAKSPESPFTV EEECCCCCCCCCCEE	36.59	25693802
611	Phosphorylation	TQAKSPESPFTVTKK CCCCCCCCCCEECHH	28.79	25693802
614	Phosphorylation	KSPESPFTVTKKESK CCCCCCCEECHHHCC	30.56	25693802
616	Phosphorylation	PESPFTVTKKESKDI CCCCCEECHHHCCCE	33.08	25693802
655	Phosphorylation	WAKLEERSPDLPGVR HHHHHHHCCCCCCCC	26.50	24702127
688	Phosphorylation	EGPSQEHSRPFSVEA CCCCCCCCCCCCHHH	40.68	25693802
692	Phosphorylation	QEHSRPFSVEALTLT CCCCCCCCHHHEEEE	23.02	25693802
697	Phosphorylation	PFSVEALTLTKLMIT CCCHHHEEEEEEEHH	39.15	25693802
699	Phosphorylation	SVEALTLTKLMITAN CHHHEEEEEEEHHCC	19.52	25693802
704	Phosphorylation	TLTKLMITANSKEQP EEEEEEHHCCCCCCC	13.06	-
707	Phosphorylation	KLMITANSKEQPSKS EEEHHCCCCCCCCHH	34.80	-
813	Phosphorylation	SLKREGISQAPIPLT HHCCCCCCCCCCCCC	31.01	29978859
820	Phosphorylation	SQAPIPLTASPWEDL CCCCCCCCCCCHHHC	21.53	25693802
822	Phosphorylation	APIPLTASPWEDLRP CCCCCCCCCHHHCCC	25.88	29978859
830	Phosphorylation	PWEDLRPSPLSETLI CHHHCCCCCCCHHHH	31.85	29978859
833	Phosphorylation	DLRPSPLSETLISKM HCCCCCCCHHHHHHH	31.74	29978859
835	Phosphorylation	RPSPLSETLISKMEA CCCCCCHHHHHHHHH	26.47	29978859
838	Phosphorylation	PLSETLISKMEATAR CCCHHHHHHHHHHHH	29.12	29978859
843	Phosphorylation	LISKMEATARASQQP HHHHHHHHHHHHHCC	11.90	-
847	Phosphorylation	MEATARASQQPKRVS HHHHHHHHHCCCCCC	24.64	28509920
908	Phosphorylation	GVLNLLPSLQHSQHS CHHHHHHHHCCCCCC	40.40	25693802
912	Phosphorylation	LLPSLQHSQHSEWPD HHHHHCCCCCCCCCC	19.34	25693802
915	Phosphorylation	SLQHSQHSEWPDAGA HHCCCCCCCCCCCCC	33.45	25693802

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of F71E2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of F71E2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of F71E2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KR103_HUMAN	KRTAP10-3	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.