ADA1B_HUMAN - dbPTM
ADA1B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ADA1B_HUMAN
UniProt AC P35368
Protein Name Alpha-1B adrenergic receptor
Gene Name ADRA1B
Organism Homo sapiens (Human).
Sequence Length 520
Subcellular Localization Nucleus membrane
Multi-pass membrane protein. Cell membrane
Multi-pass membrane protein . Cytoplasm . Membrane, caveola . Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes.
Protein Description This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes..
Protein Sequence MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCLSGSQRTLPSASPSPGYLGRGAPPPVELCAFPEWKAPGALLSLPAPEPPGRRGRHDSGPLFTFKLLTEPESPGTDGGASNGGCEAAADVANGQPGFKSNMPLAPGQF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10N-linked_GlycosylationPDLDTGHNTSAPAHW
CCCCCCCCCCCCCCH		36.75UniProtKB CARBOHYD
24N-linked_GlycosylationWGELKNANFTGPNQT
HHCCCCCCCCCCCCC		44.39UniProtKB CARBOHYD
29N-linked_GlycosylationNANFTGPNQTSSNST
CCCCCCCCCCCCCCC		60.14UniProtKB CARBOHYD
34N-linked_GlycosylationGPNQTSSNSTLPQLD
CCCCCCCCCCCCHHH		38.49UniProtKB CARBOHYD
144PhosphorylationCAISIDRYIGVRYSL
HHHHHHHCCCCHHCC		9.7711136215
149PhosphorylationDRYIGVRYSLQYPTL
HHCCCCHHCCCCCCH		16.019426637
153PhosphorylationGVRYSLQYPTLVTRR
CCHHCCCCCCHHHHH		11.959426651
227PhosphorylationLVMYCRVYIVAKRTT
HHHHHHHHHHCCCCC		3.1328060719
233PhosphorylationVYIVAKRTTKNLEAG
HHHHCCCCCCCCHHH		41.2223312004
234PhosphorylationYIVAKRTTKNLEAGV
HHHCCCCCCCCHHHH		23.2023312004
246PhosphorylationAGVMKEMSNSKELTL
HHHHHHHCCCCEEEE		38.7623312004
248PhosphorylationVMKEMSNSKELTLRI
HHHHHCCCCEEEEEE		21.8723312004
249UbiquitinationMKEMSNSKELTLRIH
HHHHCCCCEEEEEEE		62.0833845483
264PhosphorylationSKNFHEDTLSSTKAK
CCCCCHHHHHCCCCC		26.09-
266PhosphorylationNFHEDTLSSTKAKGH
CCCHHHHHCCCCCCC		37.7528348404
267PhosphorylationFHEDTLSSTKAKGHN
CCHHHHHCCCCCCCC		36.7222777824
269UbiquitinationEDTLSSTKAKGHNPR
HHHHHCCCCCCCCCC		50.4733845483
365S-palmitoylationAFVRILGCQCRGRGR
HHHHHHCCCCCCCCH		2.86-
389MethylationGGCAYTYRPWTRGGS
CCCCCCCCCCCCCCC		16.69-
389DimethylationGGCAYTYRPWTRGGS
CCCCCCCCCCCCCCC		16.69-
393MethylationYTYRPWTRGGSLERS
CCCCCCCCCCCCCCC		43.54-
393DimethylationYTYRPWTRGGSLERS
CCCCCCCCCCCCCCC		43.54-
396PhosphorylationRPWTRGGSLERSQSR
CCCCCCCCCCCCCCC		29.859353340
399MethylationTRGGSLERSQSRKDS
CCCCCCCCCCCCCCC		45.34-
399DimethylationTRGGSLERSQSRKDS
CCCCCCCCCCCCCCC		45.34-
402PhosphorylationGSLERSQSRKDSLDD
CCCCCCCCCCCCCCC		42.419353340
403MethylationSLERSQSRKDSLDDS
CCCCCCCCCCCCCCC		38.88-
403DimethylationSLERSQSRKDSLDDS
CCCCCCCCCCCCCCC		38.88-
406PhosphorylationRSQSRKDSLDDSGSC
CCCCCCCCCCCCCCC		36.4128857561
410PhosphorylationRKDSLDDSGSCLSGS
CCCCCCCCCCCCCCC		32.0725985
412PhosphorylationDSLDDSGSCLSGSQR
CCCCCCCCCCCCCCC		18.819353340
417PhosphorylationSGSCLSGSQRTLPSA
CCCCCCCCCCCCCCC		17.08144827
470PhosphorylationGRRGRHDSGPLFTFK
CCCCCCCCCCCEEEE		35.8627422710
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ADA1B_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ADA1B_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ADA1B_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AP2M1_HUMANAP2M1physical
12644451
ADA1B_HUMANADRA1Bphysical
12888550
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00076 Noradrenaline (JP16); Norepinephrine (INN); Nor adrenalin (TN)
D00095 Adrenaline (JP16); Epinephrine (USP/INN); Adrenalin (TN); Auvi-q (TN); Epipen (TN)
D00124 Ephedrine (USP); Ephedrine (TN)
D00255 Carvedilol (JAN/USAN/INN); Artist (TN); Coreg (TN)
D00283 Clozapine (JAN/USP/INN); Clozaril (TN)
D00403 Levomepromazine (USAN/INN); Methotrimeprazine (USP); Levoprome (TN)
D00426 Risperidone (JP16/USAN/INN); Risperdal (TN)
D00454 Olanzapine (JAN/USAN/INN); Zyprexa (TN)
D00458 Quetiapine fumarate (JP16/USAN); Seroquel (TN)
D00485 Pseudoephedrine hydrochloride (USP); Sudafed (TN)
D00507 Phenoxybenzamine hydrochloride (USP); Dibenzyline (TN)
D00509 Phentolamine mesilate (JAN/INN); Phentolamine mesylate (USP); Regitine (TN)
D00511 Phenylephrine hydrochloride (JP16/USP); Neo-synephrine (TN)
D00560 Pimozide (JP16/USP/INN); Orap (TN)
D00561 Sertindole (USAN/INN); SerLect (TN)
D00600 Labetalol hydrochloride (JP16/USP); Normodyne (TN); Trandate (TN)
D00607 Guanadrel sulfate (USP); Hylorel (TN)
D00608 Doxazosin mesilate (JP16); Doxazosin mesylate (USAN); Cardura (TN)
D00609 Prazosin hydrochloride (JP16/USP); Minipress (TN)
D00610 Terazosin hydrochloride hydrate (JAN); Terazosin hydrochloride (USAN); Hytrin (TN)
D00636 Amiodarone hydrochloride (JP16/USAN); Ancaron (TN); Cordarone (TN)
D00679 Ergotamine tartrate (JP16/USP); Ergomar (TN)
D00680 Methylergometrine maleate (JP16); Methylergonovine maleate (USP); Methergine (TN)
D00743 Naphazoline hydrochloride (JP16/USP); Albalon (TN); Vasocon (TN)
D00756 Tetrahydrozoline nitrate (JAN); Narbel (TN)
D00757 Xylometazoline hydrochloride (USP); Neo-Synephrine II (TN)
D00996 Epinephrine hydrochloride (JAN); Adrenalin chloride (TN)
D00997 Tolazoline hydrochloride (JAN/USP); Priscoline (TN)
D01017 Dipivefrin hydrochloride (JAN/USP); Propine (TN)
D01019 Metaraminol bitartrate (JAN/USP); Aramine (TN)
D01020 Methoxamine hydrochloride (JAN); Vasoxyl (TN)
D01021 Naphazoline nitrate (JP16); Privine (TN)
D01022 Oxymetazoline hydrochloride (JAN/USP); Ocuclear (TN)
D01023 Tetrahydrozoline hydrochloride (JAN/USP); Tyzine (TN)
D01024 Tamsulosin hydrochloride (JP16/USAN); Flomax (TN); Harnal (TN)
D01025 Levobunolol hydrochloride (JAN/USP); Betagan (TN)
D01163 Ergometrine maleate (JP16); Ergonovine maleate (USP); Ergometrine (TN)
D01290 Nicergoline (JP16/USAN/INN); Sermion (TN)
D01307 Midodrine hydrochloride (JAN/USAN); Pro-Amatine (TN)
D01333 Urapidil (JP16/INN); Ebrantil (TN)
D01347 Tramazoline hydrochloride (JAN/USAN); Towk (TN)
D01358 Mianserin hydrochloride (JAN/USAN); Tetramide (TN)
D01386 Ephedrine hydrochloride (JP16/USP); Ephedrine hydrochloride (TN)
D01405 Norfenefrine hydrochloride (JAN); Zondel (TN)
D01444 Bunitrolol hydrochloride (JAN); Betrilol (TN)
D01445 Ifenprodil tartrate (JP16); Cerocral (TN)
D01469 Amosulalol hydrochloride (JP16); Lowgan (TN)
D01520 Levomepromazine hydrochloride (JAN/USAN); Nozinan (TN)
D01571 Moxisylyte hydrochloride (JAN); Opilon (TN)
D01573 Etilefrine hydrochloride (JP16); Etilefrine hydrochloride (TN)
D01674 Naftopidil (JAN/INN); Flivas (TN)
D01691 Nipradilol (JAN/INN); Hypadil (TN)
D01692 Alfuzosin hydrochloride (JAN/USAN); Uroxatral (TN)
D01830 Arotinolol hydrochloride (JP16); Almarl (TN)
D01887 Bunazosin hydrochloride (JP16); Detantol (TN)
D01952 L-Methylephedrine hydrochloride (JAN)
D01965 Silodosin (JAN/INN); KMD 3213; Rapaflo (TN); Urief (TN)
D02034 Setiptiline maleate (JAN); Tecipul (TN)
D02109 dl-Methylephedrine hydrochloride (JP16); Methy-F (TN)
D02149 Epinephrine bitartrate (JAN/USP); Asmatane mist (TN); Medihaler-epi (TN)
D02211 Dihydroergotamine mesilate (JP16); Dihydroergotamine mesylate (USP); Migranal (TN)
D02248 Levomepromazine maleate (JP16/USAN); Hirnamin (TN)
D02349 Dipivefrin (USAN); Dipivefrine (INN)
D02363 Ketanserin (USAN/INN)
D02537 Dronedarone (INN)
D02901 Amidephrine mesylate (USAN); Amidefrine mesilate (INN)
D02910 Amiodarone (USAN/INN)
D02976 Arbutamine hydrochloride (USAN); Genesa (TN)
D02995 Asenapine maleate (USAN); Saphris (TN)
D03415 Carvedilol phosphate hydrate (JAN); Carvedilol phosphate (USAN); Coreg CR (TN)
D03648 Dapiprazole hydrochloride (USAN); Rev-Eyes (TN)
D03914 Dronedarone hydrochloride (USAN); Multaq (TN)
D04018 Ephedrine sulfate (USP); Isofedrol (TN)
D04531 Indoramin (USAN/INN)
D04532 Indoramin hydrochloride (USAN)
D04888 Medroxalol (USAN/INN)
D04889 Medroxalol hydrochloride (USAN)
D05206 Norepinephrine bitartrate (USP); Levophed (TN)
D05395 Pelanserin hydrochloride (USAN)
D05648 Pseudoephedrine polistirex (USAN); Pseudo-12 (TN)
D05649 Pseudoephedrine sulfate (USP); Afrinol (TN)
D06234 Trimazosin hydrochloride (USAN); Trimazosin hydrochloride monohydrate
D06623 Olanzapine pamoate (USAN); Olanzapine pamoate monohydrate
D07124 Alfuzosin (INN); Xatral (TN)
D07148 Oxedrine (BAN); (+/-)-Synephrine
D07451 Amosulalol (INN)
D07465 Arotinolol (INN)
D07550 Bunazosin (INN)
D07837 Dihydroergotamine (INN); Neomigran (TN)
D07838 Dihydroergotamine tartrate; Divegal (TN)
D07874 Doxazosin (INN); Cardura XL (TN)
D07905 Ergometrine (INN)
D07906 Ergotamine (INN)
D07931 Etilefrine (INN); Corcanfol (TN)
D08064 Ifenprodil (INN)
D08099 Ketanserin tartrate; Sufrexal (TN)
D08106 Labetalol (INN)
D08115 Levobunolol (INN)
D08192 Metaraminol (INN)
D08201 Methoxamine (BAN)
D08206 Methylephedrine (BAN)
D08207 Methylergometrine (INN); Ergotyl (TN)
D08212 Trimazosin (INN)
D08216 Mianserin (INN); Tolvon (TN)
D08220 Midodrine (INN)
D08239 Moxisylyte (INN); Carlytene (TN)
D08253 Naphazoline (INN); Nafazolin (TN)
D08271 Nicergoline tartrate; Sermion (TN)
D08284 Norepinephrine hydrochoride; (-)-Noradrenaline hydrochloride; Arterenol (TN)
D08286 Norfenefrine (INN)
D08308 Oxedrine tartrate; Dacryoboraline (TN)
D08309 Oxedrine hydrochloride; Ocuton (TN)
D08322 Oxymetazoline (INN); Operil (TN)
D08358 Phenoxybenzamine (INN)
D08362 Phentolamine (INN)
D08365 Phenylephrine (INN); Phenylephrine Minims (TN)
D08366 Phenylephrine tartrate; L-Phenylephrine tartrate; Boraline (TN)
D08411 Prazosin (INN); Minipress (TN)
D08449 Pseudoephedrine (INN); Neodurasina (TN); Acunaso (TN)
D08456 Quetiapine (INN); Norsic (TN)
D08511 Setiptiline (INN)
D08560 Tamsulosin (INN); Flomax (TN); Tamsulon (TN)
D08569 Terazosin (INN); Terazosabb (TN)
D08578 Tetryzoline (INN); Tetrahydrozoline; Caltheon (TN)
D08614 Tolazoline (INN); Tolazine [veterinary] (TN)
D08624 Tramazoline (INN); Muconasal (TN)
D08662 Urapidil hydrochloride; Ebrantil (TN)
D08684 Xylometazoline (INN); Balminil (TN)
D08966 Phenylephrine bitartrate (USP)
D09794 Norepinephrine hydrochloride (JAN); (+/-)-Noradrenaline hydrochloride
D09842 dl-Methylephedrine saccharinate (JAN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ADA1B_HUMAN

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Related Literatures of Post-Translational Modification

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