CXG2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CXG2_HUMAN
• UniProt AC: Q5T442
• Protein Name: Gap junction gamma-2 protein
• Gene Name: GJC2
• Organism: Homo sapiens (Human).
• Sequence Length: 439
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
• Protein Description: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems..
• Protein Sequence: MTNMSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGCDNVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPGPRRAPRAHLPPPHAGWPEPADLGEEEPMLGLGEEEEEEETGAAEGAGEEAEEAGAEEACTKAVGADGKAAGTPGPTGQHDGRRRIQREGLMRVYVAQLVARAAFEVAFLVGQYLLYGFEVRPFFPCSRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGLGSAQDAVRGRRGPPASAPAPAPRPPPCAFPAAAAGLACPPDYSLVVRAAERARAHDQNLANLALQALRDGAAAGDRDRDSSPCVGLPAASRGPPRAGAPASRTGSATSAGTVGEQGRPGTHERPGAKPRAGSEKGSASSRDGKTTVWI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	O-linked_Glycosylation	NMSWSFLTRLLEEIH CCCHHHHHHHHHHHH	19.77	30620550
232	Phosphorylation	VAFLVGQYLLYGFEV HHHHHHHHHHHCCEE	7.86	-
235	Phosphorylation	LVGQYLLYGFEVRPF HHHHHHHHCCEEECC	19.71	-
371	Phosphorylation	AGDRDRDSSPCVGLP CCCCCCCCCCCCCCC	36.75	-
423	Phosphorylation	GAKPRAGSEKGSASS CCCCCCCCCCCCCCC	34.84	27251275
427	Phosphorylation	RAGSEKGSASSRDGK CCCCCCCCCCCCCCC	35.72	27251275
429	Phosphorylation	GSEKGSASSRDGKTT CCCCCCCCCCCCCEE	27.83	27251275
430	Phosphorylation	SEKGSASSRDGKTTV CCCCCCCCCCCCEEE	33.82	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CXG2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CXG2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CXG2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CXG2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.