AMPD3_HUMAN - dbPTM
AMPD3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AMPD3_HUMAN
UniProt AC Q01432
Protein Name AMP deaminase 3
Gene Name AMPD3
Organism Homo sapiens (Human).
Sequence Length 767
Subcellular Localization
Protein Description AMP deaminase plays a critical role in energy metabolism..
Protein Sequence MPRQFPKLNISEVDEQVRLLAEKVFAKVLREEDSKDALSLFTVPEDCPIGQKEAKERELQKELAEQKSVETAKRKKSFKMIRSQSLSLQMPPQQDWKGPPAASPAMSPTTPVVTGATSLPTPAPYAMPEFQRVTISGDYCAGITLEDYEQAAKSLAKALMIREKYARLAYHRFPRITSQYLGHPRADTAPPEEGLPDFHPPPLPQEDPYCLDDAPPNLDYLVHMQGGILFVYDNKKMLEHQEPHSLPYPDLETYTVDMSHILALITDGPTKTYCHRRLNFLESKFSLHEMLNEMSEFKELKSNPHRDFYNVRKVDTHIHAAACMNQKHLLRFIKHTYQTEPDRTVAEKRGRKITLRQVFDGLHMDPYDLTVDSLDVHAGRQTFHRFDKFNSKYNPVGASELRDLYLKTENYLGGEYFARMVKEVARELEESKYQYSEPRLSIYGRSPEEWPNLAYWFIQHKVYSPNMRWIIQVPRIYDIFRSKKLLPNFGKMLENIFLPLFKATINPQDHRELHLFLKYVTGFDSVDDESKHSDHMFSDKSPNPDVWTSEQNPPYSYYLYYMYANIMVLNNLRRERGLSTFLFRPHCGEAGSITHLVSAFLTADNISHGLLLKKSPVLQYLYYLAQIPIAMSPLSNNSLFLEYSKNPLREFLHKGLHVSLSTDDPMQFHYTKEALMEEYAIAAQVWKLSTCDLCEIARNSVLQSGLSHQEKQKFLGQNYYKEGPEGNDIRKTNVAQIRMAFRYETLCNELSFLSDAMKSEEITALTN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5 (in isoform 3)Phosphorylation-6.43-
5 (in isoform 5)Phosphorylation-6.43-
7Ubiquitination-MPRQFPKLNISEVD
-CCCCCCCCCHHHHH		56.2929967540
14UbiquitinationKLNISEVDEQVRLLA
CCCHHHHHHHHHHHH		36.2429967540
16UbiquitinationNISEVDEQVRLLAEK
CHHHHHHHHHHHHHH		22.5929967540
23UbiquitinationQVRLLAEKVFAKVLR
HHHHHHHHHHHHHHC		36.7329967540
27MethylationLAEKVFAKVLREEDS
HHHHHHHHHHCCCCC		30.27-
27UbiquitinationLAEKVFAKVLREEDS
HHHHHHHHHHCCCCC		30.2727667366
30UbiquitinationKVFAKVLREEDSKDA
HHHHHHHCCCCCCCH		48.5229967540
32UbiquitinationFAKVLREEDSKDALS
HHHHHCCCCCCCHHH		62.2429967540
32 (in isoform 4)Ubiquitination-62.24-
34UbiquitinationKVLREEDSKDALSLF
HHHCCCCCCCHHHHC		35.4027667366
35UbiquitinationVLREEDSKDALSLFT
HHCCCCCCCHHHHCC		60.3829967540
36UbiquitinationLREEDSKDALSLFTV
HCCCCCCCHHHHCCC		57.6127667366
36 (in isoform 4)Ubiquitination-57.61-
42UbiquitinationKDALSLFTVPEDCPI
CCHHHHCCCCCCCCC		40.2129967540
44UbiquitinationALSLFTVPEDCPIGQ
HHHHCCCCCCCCCCH		28.7529967540
44 (in isoform 4)Ubiquitination-28.75-
61UbiquitinationAKERELQKELAEQKS
HHHHHHHHHHHHHHC		68.28-
67UbiquitinationQKELAEQKSVETAKR
HHHHHHHHCHHHHHH		48.23-
68PhosphorylationKELAEQKSVETAKRK
HHHHHHHCHHHHHHH		25.5328857561
70 (in isoform 4)Ubiquitination-50.57-
76 (in isoform 4)Ubiquitination-66.22-
83PhosphorylationKSFKMIRSQSLSLQM
HHHHHHHHHCCCCCC		17.1320058876
85PhosphorylationFKMIRSQSLSLQMPP
HHHHHHHCCCCCCCC		22.6023401153
87PhosphorylationMIRSQSLSLQMPPQQ
HHHHHCCCCCCCCCC		23.089391917
94 (in isoform 4)Phosphorylation-65.3924719451
103PhosphorylationWKGPPAASPAMSPTT
CCCCCCCCCCCCCCC		18.4622199227
107PhosphorylationPAASPAMSPTTPVVT
CCCCCCCCCCCCCCC		22.6228102081
109PhosphorylationASPAMSPTTPVVTGA
CCCCCCCCCCCCCCC		36.1022199227
110PhosphorylationSPAMSPTTPVVTGAT
CCCCCCCCCCCCCCC		19.9222199227
112 (in isoform 4)Phosphorylation-5.9027251275
114PhosphorylationSPTTPVVTGATSLPT
CCCCCCCCCCCCCCC		22.7222199227
117PhosphorylationTPVVTGATSLPTPAP
CCCCCCCCCCCCCCC		31.9426074081
118PhosphorylationPVVTGATSLPTPAPY
CCCCCCCCCCCCCCC		31.6426074081
121PhosphorylationTGATSLPTPAPYAMP
CCCCCCCCCCCCCCC		37.0626074081
123 (in isoform 4)Phosphorylation-16.5327251275
125PhosphorylationSLPTPAPYAMPEFQR
CCCCCCCCCCCCCEE		20.0326074081
127 (in isoform 4)Phosphorylation-2.4227251275
139UbiquitinationRVTISGDYCAGITLE
EEEECCCEEECCCHH		6.4229967540
157UbiquitinationQAAKSLAKALMIREK
HHHHHHHHHHHHHHH		47.55-
166 (in isoform 4)Ubiquitination-15.87-
170PhosphorylationEKYARLAYHRFPRIT
HHHHHHHHHHCCCCC		9.7120068231
178PhosphorylationHRFPRITSQYLGHPR
HHCCCCCHHHCCCCC		17.9230804221
189 (in isoform 4)Phosphorylation-20.4227642862
263UbiquitinationVDMSHILALITDGPT
ECHHHHHHHHCCCCC		9.0529967540
273UbiquitinationTDGPTKTYCHRRLNF
CCCCCHHHHHHHHHH		6.4422505724
298UbiquitinationLNEMSEFKELKSNPH
HHHHHHHHHHHCCCC		59.0729967540
301UbiquitinationMSEFKELKSNPHRDF
HHHHHHHHCCCCCCC		49.64-
302PhosphorylationSEFKELKSNPHRDFY
HHHHHHHCCCCCCCC		69.1223532336
305UbiquitinationKELKSNPHRDFYNVR
HHHHCCCCCCCCCHH		46.3129967540
307UbiquitinationLKSNPHRDFYNVRKV
HHCCCCCCCCCHHCC		47.5529967540
307 (in isoform 4)Ubiquitination-47.55-
310 (in isoform 4)Ubiquitination-27.41-
343UbiquitinationTYQTEPDRTVAEKRG
HHCCCCCCHHHHHHC		41.6430230243
344PhosphorylationYQTEPDRTVAEKRGR
HCCCCCCHHHHHHCC		31.2920068231
348UbiquitinationPDRTVAEKRGRKITL
CCCHHHHHHCCEEEH		50.87-
357 (in isoform 4)Ubiquitination-43.26-
388UbiquitinationQTFHRFDKFNSKYNP
HHCCCHHHCCCCCCC		43.67-
401 (in isoform 4)Ubiquitination-4.84-
407UbiquitinationELRDLYLKTENYLGG
HHHHHHHHCCCCCCH		39.99-
416 (in isoform 4)Ubiquitination-13.05-
422UbiquitinationEYFARMVKEVARELE
HHHHHHHHHHHHHHH		36.8129967540
429UbiquitinationKEVARELEESKYQYS
HHHHHHHHHHCCCCC		56.3129967540
431PhosphorylationVARELEESKYQYSEP
HHHHHHHHCCCCCCC		27.5646163045
431UbiquitinationVARELEESKYQYSEP
HHHHHHHHCCCCCCC		27.5629967540
431 (in isoform 4)Ubiquitination-27.56-
432UbiquitinationARELEESKYQYSEPR
HHHHHHHCCCCCCCC		39.3921906983
432 (in isoform 1)Ubiquitination-39.3921906983
433PhosphorylationRELEESKYQYSEPRL
HHHHHHCCCCCCCCE		23.206992111
435PhosphorylationLEESKYQYSEPRLSI
HHHHCCCCCCCCEEE		16.3546163051
439UbiquitinationKYQYSEPRLSIYGRS
CCCCCCCCEEECCCC		36.7022505724
439 (in isoform 3)Ubiquitination-36.7021906983
441UbiquitinationQYSEPRLSIYGRSPE
CCCCCCEEECCCCHH		18.2922505724
441 (in isoform 2)Ubiquitination-18.2921906983
441 (in isoform 4)Ubiquitination-18.29-
442 (in isoform 4)Phosphorylation-5.1027642862
502UbiquitinationNIFLPLFKATINPQD
HHHHHHHHCCCCCCC		52.9130230243
509UbiquitinationKATINPQDHRELHLF
HCCCCCCCHHHHHHH		44.0330230243
511UbiquitinationTINPQDHRELHLFLK
CCCCCCHHHHHHHHH		57.3630230243
521PhosphorylationHLFLKYVTGFDSVDD
HHHHHHHHCCCCCCC		29.1050564979
525PhosphorylationKYVTGFDSVDDESKH
HHHHCCCCCCCCCCC		25.7850564985
530PhosphorylationFDSVDDESKHSDHMF
CCCCCCCCCCCCCCC		42.5450564991
538PhosphorylationKHSDHMFSDKSPNPD
CCCCCCCCCCCCCCC		36.2350564997
552UbiquitinationDVWTSEQNPPYSYYL
CCCCCCCCCCCHHHH		35.1529967540
562UbiquitinationYSYYLYYMYANIMVL
CHHHHHHHHHHHHHH		1.2829967540
711UbiquitinationSGLSHQEKQKFLGQN
HCCCHHHHHHHHCCC		52.8229967540
713UbiquitinationLSHQEKQKFLGQNYY
CCHHHHHHHHCCCCC		54.33-
718UbiquitinationKQKFLGQNYYKEGPE
HHHHHCCCCCCCCCC		40.0629967540
720UbiquitinationKFLGQNYYKEGPEGN
HHHCCCCCCCCCCCC		15.3129967540
721UbiquitinationFLGQNYYKEGPEGND
HHCCCCCCCCCCCCC		45.922190698
721 (in isoform 1)Ubiquitination-45.9221906983
722 (in isoform 4)Ubiquitination-64.95-
728UbiquitinationKEGPEGNDIRKTNVA
CCCCCCCCCCCCCHH		53.5829967540
728 (in isoform 3)Ubiquitination-53.5821906983
730UbiquitinationGPEGNDIRKTNVAQI
CCCCCCCCCCCHHHH		42.4829967540
730 (in isoform 2)Ubiquitination-42.4821906983
730 (in isoform 4)Ubiquitination-42.48-
731UbiquitinationPEGNDIRKTNVAQIR
CCCCCCCCCCHHHHH		44.80-
732PhosphorylationEGNDIRKTNVAQIRM
CCCCCCCCCHHHHHH		25.6950564973
740 (in isoform 4)Ubiquitination-3.95-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AMPD3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AMPD3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AMPD3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of AMPD3_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
612874Adenosine monophosphate deaminase deficiency erythrocyte type (AMPDDE)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AMPD3_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107, AND MASSSPECTROMETRY.

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