dbPTM

TLN2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TLN2_HUMAN
UniProt AC	Q9Y4G6
Protein Name	Talin-2
Gene Name	TLN2
Organism	Homo sapiens (Human).
Sequence Length	2542
Subcellular Localization	Cytoplasm . Cell junction, focal adhesion . Cell junction, synapse . Cell membrane Peripheral membrane protein Cytoplasmic side . Cytoplasm, cytoskeleton . Focal adhesion plaques and synapses (PubMed:12422219).
Protein Description	As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity)..
Protein Sequence	MVALSLKICVRHCNVVKTMQFEPSTAVYDACRVIRERVPEAQTGQASDYGLFLSDEDPRKGIWLEAGRTLDYYMLRNGDILEYKKKQRPQKIRMLDGSVKTVMVDDSKTVGELLVTICSRIGITNYEEYSLIQETIEEKKEEGTGTLKKDRTLLRDERKMEKLKAKLHTDDDLNWLDHSRTFREQGVDENETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFEKACEFGGFQAQIQFGPHVEHKHKPGFLDLKEFLPKEYIKQRGAEKRIFQEHKNCGEMSEIEAKVKYVKLARSLRTYGVSFFLVKEKMKGKNKLVPRLLGITKDSVMRVDEKTKEVLQEWPLTTVKRWAASPKSFTLDFGEYQESYYSVQTTEGEQISQLIAGYIDIILKKKQSKDRFGLEGDEESTMLEESVSPKKSTILQQQFNRTGKAEHGSVALPAVMRSGSSGPETFNVGSMPSPQQQVMVGQMHRGHMPPLTSAQQALMGTINTSMHAVQQAQDDLSELDSLPPLGQDMASRVWVQNKVDESKHEIHSQVDAITAGTASVVNLTAGDPADTDYTAVGCAITTISSNLTEMSKGVKLLAALMDDEVGSGEDLLRAARTLAGAVSDLLKAVQPTSGEPRQTVLTAAGSIGQASGDLLRQIGENETDERFQDVLMSLAKAVANAAAMLVLKAKNVAQVAEDTVLQNRVIAAATQCALSTSQLVACAKVVSPTISSPVCQEQLIEAGKLVDRSVENCVRACQAATTDSELLKQVSAAASVVSQALHDLLQHVRQFASRGEPIGRYDQATDTIMCVTESIFSSMGDAGEMVRQARVLAQATSDLVNAMRSDAEAEIDMENSKKLLAAAKLLADSTARMVEAAKGAAANPENEDQQQRLREAAEGLRVATNAAAQNAIKKKIVNRLEVAAKQAAAAATQTIAASQNAAVSNKNPAAQQQLVQSCKAVADHIPQLVQGVRGSQAQAEDLSAQLALIISSQNFLQPGSKMVSSAKAAVPTVSDQAAAMQLSQCAKNLATSLAELRTASQKAHEACGPMEIDSALNTVQTLKNELQDAKMAAVESQLKPLPGETLEKCAQDLGSTSKAVGSSMAQLLTCAAQGNEHYTGVAARETAQALKTLAQAARGVAASTTDPAAAHAMLDSARDVMEGSAMLIQEAKQALIAPGDAERQQRLAQVAKAVSHSLNNCVNCLPGQKDVDVALKSIGESSKKLLVDSLPPSTKPFQEAQSELNQAAADLNQSAGEVVHATRGQSGELAAASGKFSDDFDEFLDAGIEMAGQAQTKEDQIQVIGNLKNISMASSKLLLAAKSLSVDPGAPNAKNLLAAAARAVTESINQLITLCTQQAPGQKECDNALRELETVKGMLDNPNEPVSDLSYFDCIESVMENSKVLGESMAGISQNAKTGDLPAFGECVGIASKALCGLTEAAAQAAYLVGISDPNSQAGHQGLVDPIQFARANQAIQMACQNLVDPGSSPSQVLSAATIVAKHTSALCNACRIASSKTANPVAKRHFVQSAKEVANSTANLVKTIKALDGDFSEDNRNKCRIATAPLIEAVENLTAFASNPEFVSIPAQISSEGSQAQEPILVSAKTMLESSSYLIRTARSLAINPKDPPTWSVLAGHSHTVSDSIKSLITSIRDKAPGQRECDYSIDGINRCIRDIEQASLAAVSQSLATRDDISVEALQEQLTSVVQEIGHLIDPIATAARGEAAQLGHKVTQLASYFEPLILAAVGVASKILDHQQQMTVLDQTKTLAESALQMLYAAKEGGGNPKAQHTHDAITEAAQLMKEAVDDIMVTLNEAASEVGLVGGMVDAIAEAMSKLDEGTPPEPKGTFVDYQTTVVKYSKAIAVTAQEMMTKSVTNPEELGGLASQMTSDYGHLAFQGQMAAATAEPEEIGFQIRTRVQDLGHGCIFLVQKAGALQVCPTDSYTKRELIECARAVTEKVSLVLSALQAGNKGTQACITAATAVSGIIADLDTTIMFATAGTLNAENSETFADHRENILKTAKALVEDTKLLVSGAASTPDKLAQAAQSSAATITQLAEVVKLGAASLGSDDPETQVVLINAIKDVAKALSDLISATKGAASKPVDDPSMYQLKGAAKVMVTNVTSLLKTVKAVEDEATRGTRALEATIECIKQELTVFQSKDVPEKTSSPEESIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRKAVSDMLTACKQASFHPDVSDEVRTRALRFGTECTLGYLDLLEHVLVILQKPTPEFKQQLAAFSKRVAGAVTELIQAAEAMKGTEWVDPEDPTVIAETELLGAAASIEAAAKKLEQLKPRAKPKQADETLDFEEQILEAAKSIAAATSALVKSASAAQRELVAQGKVGSIPANAADDGQWSQGLISAARMVAAATSSLCEAANASVQGHASEEKLISSAKQVAASTAQLLVACKVKADQDSEAMRRLQAAGNAVKRASDNLVRAAQKAAFGKADDDDVVVKTKFVGGIAQIIAAQEEMLKKERELEEARKKLAQIRQQQYKFLPTELREDEG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MVALSLKICVRH ---CCCHHHEHHHHH	20.20	24719451
17	Malonylation	VRHCNVVKTMQFEPS HHHCCEEEEECCCCC	33.72	26320211
17	Ubiquitination	VRHCNVVKTMQFEPS HHHCCEEEEECCCCC	33.72	29967540
18	Phosphorylation	RHCNVVKTMQFEPST HHCCEEEEECCCCCH	12.47	26074081
24	Phosphorylation	KTMQFEPSTAVYDAC EEECCCCCHHHHHHH	23.08	26074081
25	Phosphorylation	TMQFEPSTAVYDACR EECCCCCHHHHHHHH	30.75	26074081
28	Phosphorylation	FEPSTAVYDACRVIR CCCCHHHHHHHHHHH	8.72	25884760
49	Phosphorylation	QTGQASDYGLFLSDE CCCCCCCCCCCCCCC	17.15	22817900
69	Phosphorylation	IWLEAGRTLDYYMLR EEEECCCCEEEEEHH	24.06	-
72	Phosphorylation	EAGRTLDYYMLRNGD ECCCCEEEEEHHCCC	8.22	25884760
73	Phosphorylation	AGRTLDYYMLRNGDI CCCCEEEEEHHCCCH	6.85	27642862
109	Phosphorylation	VMVDDSKTVGELLVT EEECCCCCHHHHHHH	37.38	29083192
116	Phosphorylation	TVGELLVTICSRIGI CHHHHHHHHHHHCCC	19.08	29083192
119	Phosphorylation	ELLVTICSRIGITNY HHHHHHHHHCCCCCH	24.07	29083192
144	Phosphorylation	EEKKEEGTGTLKKDR HHHHHHCCCCCCCCH	30.21	23403867
146	Phosphorylation	KKEEGTGTLKKDRTL HHHHCCCCCCCCHHH	34.93	23403867
152	Phosphorylation	GTLKKDRTLLRDERK CCCCCCHHHHHCHHH	40.03	26437602
166	Ubiquitination	KMEKLKAKLHTDDDL HHHHHHHHCCCCCCC	38.93	29967540
169	Phosphorylation	KLKAKLHTDDDLNWL HHHHHCCCCCCCHHH	52.11	20068231
179	Phosphorylation	DLNWLDHSRTFREQG CCHHHHHCHHHHHCC	32.46	20068231
192	Phosphorylation	QGVDENETLLLRRKF CCCCCCCCEEEEEHH	34.00	28857561
201	Phosphorylation	LLRRKFFYSDQNVDS EEEEHHHHCCCCCCC	17.92	22817900
307	Phosphorylation	KYVKLARSLRTYGVS HHHHHHHHHHHHCCE	19.32	23312004
310	Phosphorylation	KLARSLRTYGVSFFL HHHHHHHHHCCEEEE	29.89	23882029
311	Phosphorylation	LARSLRTYGVSFFLV HHHHHHHHCCEEEEE	14.75	-
314	Phosphorylation	SLRTYGVSFFLVKEK HHHHHCCEEEEECHH	13.10	-
327	Ubiquitination	EKMKGKNKLVPRLLG HHHCCCCCCHHHHHC	55.11	27667366
336	Phosphorylation	VPRLLGITKDSVMRV HHHHHCCCHHHEECC	27.31	-
337	Ubiquitination	PRLLGITKDSVMRVD HHHHCCCHHHEECCC	46.19	30230243
339	Phosphorylation	LLGITKDSVMRVDEK HHCCCHHHEECCCHH	21.26	-
365	Phosphorylation	TVKRWAASPKSFTLD HHHHHCCCCCEEEEC	25.72	24719451
420	Phosphorylation	GLEGDEESTMLEESV CCCCCHHHHHHHCCC	19.64	30576142
421	Phosphorylation	LEGDEESTMLEESVS CCCCHHHHHHHCCCC	29.11	30576142
426	Phosphorylation	ESTMLEESVSPKKST HHHHHHCCCCCCHHH	20.65	30576142
428	Phosphorylation	TMLEESVSPKKSTIL HHHHCCCCCCHHHHH	40.04	19664994
432	Phosphorylation	ESVSPKKSTILQQQF CCCCCCHHHHHHHHH	27.14	28857561
433	Phosphorylation	SVSPKKSTILQQQFN CCCCCHHHHHHHHHH	34.29	28857561
442	Phosphorylation	LQQQFNRTGKAEHGS HHHHHHCCCCCCCCC	44.10	28555341
449	Phosphorylation	TGKAEHGSVALPAVM CCCCCCCCCCHHCHH	13.21	28857561
458	Phosphorylation	ALPAVMRSGSSGPET CHHCHHCCCCCCCCC	25.57	26657352
460	Phosphorylation	PAVMRSGSSGPETFN HCHHCCCCCCCCCCC	33.11	22199227
461	Phosphorylation	AVMRSGSSGPETFNV CHHCCCCCCCCCCCC	62.99	22199227
465	Phosphorylation	SGSSGPETFNVGSMP CCCCCCCCCCCCCCC	24.52	22199227
470	Phosphorylation	PETFNVGSMPSPQQQ CCCCCCCCCCCHHHE	24.20	28857561
473	Phosphorylation	FNVGSMPSPQQQVMV CCCCCCCCHHHEEEH	27.05	22199227
521	Phosphorylation	DDLSELDSLPPLGQD HCHHHHHCCCCCCCC	56.23	24275569
623	Phosphorylation	RTLAGAVSDLLKAVQ HHHHHHHHHHHHHHC	23.23	27251275
632	Phosphorylation	LLKAVQPTSGEPRQT HHHHHCCCCCCCCCH	32.07	-
633	Phosphorylation	LKAVQPTSGEPRQTV HHHHCCCCCCCCCHH	48.09	-
639	Phosphorylation	TSGEPRQTVLTAAGS CCCCCCCHHHHHHHH	20.82	20068231
642	Phosphorylation	EPRQTVLTAAGSIGQ CCCCHHHHHHHHHHH	15.32	20068231
646	Phosphorylation	TVLTAAGSIGQASGD HHHHHHHHHHHHHHH	20.86	20068231
651	Phosphorylation	AGSIGQASGDLLRQI HHHHHHHHHHHHHHH	25.59	20068231
673	Phosphorylation	RFQDVLMSLAKAVAN HHHHHHHHHHHHHHH	22.48	-
690	Ubiquitination	AMLVLKAKNVAQVAE HHHHHHHCCHHHHHH	50.82	29967540
727	Phosphorylation	VACAKVVSPTISSPV HHHHHHHCCCCCCHH	21.22	29802988
729	Phosphorylation	CAKVVSPTISSPVCQ HHHHHCCCCCCHHHH	26.45	28348404
731	Phosphorylation	KVVSPTISSPVCQEQ HHHCCCCCCHHHHHH	30.94	28348404
732	Phosphorylation	VVSPTISSPVCQEQL HHCCCCCCHHHHHHH	19.94	29802988
761	Phosphorylation	VRACQAATTDSELLK HHHHHHCCCCHHHHH	33.86	29396449
762	Phosphorylation	RACQAATTDSELLKQ HHHHHCCCCHHHHHH	32.57	29396449
764	Phosphorylation	CQAATTDSELLKQVS HHHCCCCHHHHHHHH	28.22	29396449
845	Phosphorylation	DLVNAMRSDAEAEID HHHHHHHCCCCHHCC	28.25	27251275
878	Ubiquitination	ARMVEAAKGAAANPE HHHHHHHHHHHCCCC	57.01	29967540
1000	Phosphorylation	QNFLQPGSKMVSSAK CCCCCCCCHHHHCCH	25.02	-
1004	Phosphorylation	QPGSKMVSSAKAAVP CCCCHHHHCCHHHCC	22.53	-
1005	Phosphorylation	PGSKMVSSAKAAVPT CCCHHHHCCHHHCCC	23.52	-
1023	Phosphorylation	QAAAMQLSQCAKNLA HHHHHHHHHHHHHHH	13.30	28857561
1031	Phosphorylation	QCAKNLATSLAELRT HHHHHHHHHHHHHHH	27.69	25850435
1032	Phosphorylation	CAKNLATSLAELRTA HHHHHHHHHHHHHHH	21.70	25850435
1118	Phosphorylation	AAQGNEHYTGVAARE HHHCCCCCCHHHHHH	10.06	26356563
1119	Phosphorylation	AQGNEHYTGVAARET HHCCCCCCHHHHHHH	27.39	26356563
1156	Phosphorylation	AAHAMLDSARDVMEG HHHHHHHHHHHHHHH	22.65	20068231
1195	Phosphorylation	AQVAKAVSHSLNNCV HHHHHHHHHHHHHHC	16.53	27251275
1197	Phosphorylation	VAKAVSHSLNNCVNC HHHHHHHHHHHHCCC	25.86	27251275
1266	Phosphorylation	VHATRGQSGELAAAS HHHCCCCCCCCHHHC	36.74	27251275
1271	Ubiquitination	GQSGELAAASGKFSD CCCCCCHHHCCCCCC	18.13	23000965
1277	Phosphorylation	AAASGKFSDDFDEFL HHHCCCCCCCHHHHH	39.49	-
1277	Ubiquitination	AAASGKFSDDFDEFL HHHCCCCCCCHHHHH	39.49	23000965
1296	Phosphorylation	EMAGQAQTKEDQIQV HHCCCCCCHHHHHHH	39.14	-
1311	Phosphorylation	IGNLKNISMASSKLL HHCHHHHHHHHHHHH	20.07	21964256
1316	Ubiquitination	NISMASSKLLLAAKS HHHHHHHHHHHHHHH	40.43	23000965
1322	Ubiquitination	SKLLLAAKSLSVDPG HHHHHHHHHCCCCCC	46.45	23000965
1325	Phosphorylation	LLAAKSLSVDPGAPN HHHHHHCCCCCCCCC	31.40	28348404
1408	Phosphorylation	NSKVLGESMAGISQN CCCHHCCHHHCCCCC	16.48	27251275
1488	Phosphorylation	QNLVDPGSSPSQVLS HHCCCCCCCHHHHHH	44.45	28348404
1489	Phosphorylation	NLVDPGSSPSQVLSA HCCCCCCCHHHHHHH	34.19	28348404
1498	Ubiquitination	SQVLSAATIVAKHTS HHHHHHHHHHHHHHH	18.72	21890473
1501	Ubiquitination	LSAATIVAKHTSALC HHHHHHHHHHHHHHH	8.28	23000965
1504	Phosphorylation	ATIVAKHTSALCNAC HHHHHHHHHHHHHHH	18.26	27732954
1505	Phosphorylation	TIVAKHTSALCNACR HHHHHHHHHHHHHHH	20.97	27732954
1537	Phosphorylation	SAKEVANSTANLVKT HHHHHHHHHHHHHHH	21.11	24275569
1543	Acetylation	NSTANLVKTIKALDG HHHHHHHHHHHHHCC	47.93	22648109
1543	Malonylation	NSTANLVKTIKALDG HHHHHHHHHHHHHCC	47.93	26320211
1543	Ubiquitination	NSTANLVKTIKALDG HHHHHHHHHHHHHCC	47.93	23000965
1546	Ubiquitination	ANLVKTIKALDGDFS HHHHHHHHHHCCCCC	48.40	23000965
1611	Phosphorylation	SAKTMLESSSYLIRT EHHHHHHCCCHHHHH	22.18	27174698
1612	Phosphorylation	AKTMLESSSYLIRTA HHHHHHCCCHHHHHH	17.39	27174698
1613	Phosphorylation	KTMLESSSYLIRTAR HHHHHCCCHHHHHHH	32.98	27174698
1614	Phosphorylation	TMLESSSYLIRTARS HHHHCCCHHHHHHHH	14.22	27174698
1618	Phosphorylation	SSSYLIRTARSLAIN CCCHHHHHHHHHCCC	21.30	27174698
1621	O-linked_Glycosylation	YLIRTARSLAINPKD HHHHHHHHHCCCCCC	21.49	30379171
1641	Phosphorylation	VLAGHSHTVSDSIKS HHCCCCCCHHHHHHH	25.39	23403867
1643	Phosphorylation	AGHSHTVSDSIKSLI CCCCCCHHHHHHHHH	27.13	26657352
1645	Phosphorylation	HSHTVSDSIKSLITS CCCCHHHHHHHHHHH	25.14	23403867
1651	Phosphorylation	DSIKSLITSIRDKAP HHHHHHHHHHHHCCC	24.32	20068231
1652	Phosphorylation	SIKSLITSIRDKAPG HHHHHHHHHHHCCCC	14.50	20068231
1665	Phosphorylation	PGQRECDYSIDGINR CCCCCCCCCCCCHHH	21.13	21082442
1666	Phosphorylation	GQRECDYSIDGINRC CCCCCCCCCCCHHHH	10.84	28152594
1686	Phosphorylation	QASLAAVSQSLATRD HHHHHHHHHHHCCCC	14.88	22210691
1793	Phosphorylation	GNPKAQHTHDAITEA CCCCHHHHHHHHHHH	14.90	20068231
1798	Phosphorylation	QHTHDAITEAAQLMK HHHHHHHHHHHHHHH	22.69	20068231
1838	Acetylation	AIAEAMSKLDEGTPP HHHHHHHCCCCCCCC	47.04	11790157
1843	Phosphorylation	MSKLDEGTPPEPKGT HHCCCCCCCCCCCCC	33.35	19664994
1854	Phosphorylation	PKGTFVDYQTTVVKY CCCCCCCCCCEEEEH	11.49	25884760
1856	Phosphorylation	GTFVDYQTTVVKYSK CCCCCCCCEEEEHHH	18.48	-
1943	Phosphorylation	GALQVCPTDSYTKRE CCCEECCCCCCCHHH	32.24	23312004
1945	Phosphorylation	LQVCPTDSYTKRELI CEECCCCCCCHHHHH	36.86	23312004
1947	Phosphorylation	VCPTDSYTKRELIEC ECCCCCCCHHHHHHH	27.81	23312004
2025	Malonylation	ENILKTAKALVEDTK HHHHHHHHHHHHCCE	47.70	26320211
2031	O-linked_Glycosylation	AKALVEDTKLLVSGA HHHHHHCCEEECCCC	15.30	30379171
2036	O-linked_Glycosylation	EDTKLLVSGAASTPD HCCEEECCCCCCCHH	23.76	30379171
2036	Phosphorylation	EDTKLLVSGAASTPD HCCEEECCCCCCCHH	23.76	21406692
2040	Phosphorylation	LLVSGAASTPDKLAQ EECCCCCCCHHHHHH	39.68	21406692
2041	Phosphorylation	LVSGAASTPDKLAQA ECCCCCCCHHHHHHH	30.68	21815630
2077	Phosphorylation	LGSDDPETQVVLINA CCCCCHHHHHHHHHH	31.86	-
2086	Ubiquitination	VVLINAIKDVAKALS HHHHHHHHHHHHHHH	43.68	23000965
2089	Ubiquitination	INAIKDVAKALSDLI HHHHHHHHHHHHHHH	11.09	23000965
2116	Malonylation	DPSMYQLKGAAKVMV CHHHHHHHHHHHHEE	30.86	32601280
2124	Phosphorylation	GAAKVMVTNVTSLLK HHHHHEEEEHHHHHH	13.08	24117733
2127	Phosphorylation	KVMVTNVTSLLKTVK HHEEEEHHHHHHHHH	18.74	22199227
2128	Phosphorylation	VMVTNVTSLLKTVKA HEEEEHHHHHHHHHH	27.67	28355574
2131	Ubiquitination	TNVTSLLKTVKAVED EEHHHHHHHHHHHHC	57.47	23000965
2132	Phosphorylation	NVTSLLKTVKAVEDE EHHHHHHHHHHHHCH	27.49	25599653
2134	Malonylation	TSLLKTVKAVEDEAT HHHHHHHHHHHCHHH	52.53	26320211
2134	Ubiquitination	TSLLKTVKAVEDEAT HHHHHHHHHHHCHHH	52.53	23000965
2144	Ubiquitination	EDEATRGTRALEATI HCHHHHHHHHHHHHH	14.96	24816145
2169	Ubiquitination	QSKDVPEKTSSPEES ECCCCCCCCCCHHHH	47.87	30230243
2170	Phosphorylation	SKDVPEKTSSPEESI CCCCCCCCCCHHHHH	32.54	26437602
2171	Phosphorylation	KDVPEKTSSPEESIR CCCCCCCCCHHHHHH	55.77	28857561
2172	Phosphorylation	DVPEKTSSPEESIRM CCCCCCCCHHHHHHH	41.38	26437602
2176	Phosphorylation	KTSSPEESIRMTKGI CCCCHHHHHHHCCCC	17.52	28857561
2180	Phosphorylation	PEESIRMTKGITMAT HHHHHHHCCCCHHHH	19.10	28270605
2181	Ubiquitination	EESIRMTKGITMATA HHHHHHCCCCHHHHH	38.68	-
2184	Phosphorylation	IRMTKGITMATAKAV HHHCCCCHHHHHHHH	14.93	28270605
2187	Phosphorylation	TKGITMATAKAVAAG CCCCHHHHHHHHHCC	20.19	28270605
2189	Ubiquitination	GITMATAKAVAAGNS CCHHHHHHHHHCCCC	38.75	24816145
2196	Phosphorylation	KAVAAGNSCRQEDVI HHHHCCCCCCHHHHH	15.12	26074081
2198	Methylation	VAAGNSCRQEDVIAT HHCCCCCCHHHHHHH	42.62	-
2214	Phosphorylation	NLSRKAVSDMLTACK CCCHHHHHHHHHHHH	23.35	-
2218	Phosphorylation	KAVSDMLTACKQASF HHHHHHHHHHHHHCC	24.30	-
2282	Phosphorylation	KRVAGAVTELIQAAE HHHHHHHHHHHHHHH	25.25	21406692
2352	Phosphorylation	QILEAAKSIAAATSA HHHHHHHHHHHHHHH	16.84	22199227
2357	Phosphorylation	AKSIAAATSALVKSA HHHHHHHHHHHHHCC	15.14	28060719
2358	Phosphorylation	KSIAAATSALVKSAS HHHHHHHHHHHHCCC	18.19	28060719
2427	Phosphorylation	ASEEKLISSAKQVAA CCHHHHHHHHHHHHH	34.38	28060719
2428	Phosphorylation	SEEKLISSAKQVAAS CHHHHHHHHHHHHHH	32.27	-
2465	Ubiquitination	QAAGNAVKRASDNLV HHHHHHHHHHHHHHH	39.58	24816145
2477	Acetylation	NLVRAAQKAAFGKAD HHHHHHHHHHHCCCC	36.63	20167786
2477	Methylation	NLVRAAQKAAFGKAD HHHHHHHHHHHCCCC	36.63	-
2482	Methylation	AQKAAFGKADDDDVV HHHHHHCCCCCCCCE	42.03	-
2491	Ubiquitination	DDDDVVVKTKFVGGI CCCCCEEEEECHHHH	34.09	24816145
2521	Ubiquitination	ELEEARKKLAQIRQQ HHHHHHHHHHHHHHH	43.43	24816145
2530	Phosphorylation	AQIRQQQYKFLPTEL HHHHHHHHCCCCHHH	10.20	23186163
2535	Phosphorylation	QQYKFLPTELREDEG HHHCCCCHHHHCCCC	50.20	24719451
2536	Ubiquitination	QYKFLPTELREDEG- HHCCCCHHHHCCCC-	43.84	24816145

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TLN2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TLN2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
2134	Malonylation	2137 (3)	E ⇒ K;Q	rs35997243	Immature fraction of reticulocytes	27863252

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
TWF2_HUMAN	TWF2	physical	22939629

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TLN2_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1543, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1843, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1843, AND MASSSPECTROMETRY.	18669648 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1843, AND MASSSPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1843, AND MASSSPECTROMETRY.	17081983 [Abstract]
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