SL9A8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SL9A8_HUMAN
• UniProt AC: Q9Y2E8
• Protein Name: Sodium/hydrogen exchanger 8
• Gene Name: SLC9A8
• Organism: Homo sapiens (Human).
• Sequence Length: 581
• Subcellular Localization: Golgi apparatus membrane ; Multi-pass membrane protein .
• Protein Description: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction..
• Protein Sequence: MGEKMAEEERFPNTTHEGFNVTLHTTLVVTTKLVLPTPGKPILPVQTGEQAQQEEQSSGMTIFFSLLVLAICIILVHLLIRYRLHFLPESVAVVSLGILMGAVIKIIEFKKLANWKEEEMFRPNMFFLLLLPPIIFESGYSLHKGNFFQNIGSITLFAVFGTAISAFVVGGGIYFLGQADVISKLNMTDSFAFGSLISAVDPVATIAIFNALHVDPVLNMLVFGESILNDAVSIVLTNTAEGLTRKNMSDVSGWQTFLQALDYFLKMFFGSAALGTLTGLISALVLKHIDLRKTPSLEFGMMIIFAYLPYGLAEGISLSGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFLCETCVFAFLGLSIFSFPHKFEISFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIMWFSGLRGAIPYALSLHLDLEPMEKRQLIGTTTIVIVLFTILLLGGSTMPLIRLMDIEDAKAHRRNKKDVNLSKTEKMGNTVESEHLSELTEEEYEAHYIRRQDLKGFVWLDAKYLNPFFTRRLTQEDLHHGRIQMKTLTNKWYEEVRQGPSGSEDDEQELL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
467	Phosphorylation	ILLLGGSTMPLIRLM HHHHCCCCCHHHHHC	26.53	22210691
500	Phosphorylation	KTEKMGNTVESEHLS HHHHHCCCCCHHHHH	21.66	28857561
507	Phosphorylation	TVESEHLSELTEEEY CCCHHHHHHCCHHHH	32.25	26657352
510	Phosphorylation	SEHLSELTEEEYEAH HHHHHHCCHHHHHHH	36.98	28348404
514	Phosphorylation	SELTEEEYEAHYIRR HHCCHHHHHHHHHHH	22.99	26657352
518	Phosphorylation	EEEYEAHYIRRQDLK HHHHHHHHHHHHHCC	11.81	28796482
523 (in isoform 2)	Phosphorylation	-	48.84	27251275
526 (in isoform 2)	Phosphorylation	-	29.63	27251275
530 (in isoform 2)	Phosphorylation	-	3.74	27642862
534 (in isoform 2)	Phosphorylation	-	17.27	27642862
544	Phosphorylation	PFFTRRLTQEDLHHG HHHHHCCCHHHHHCC	28.27	23927012
556	Ubiquitination	HHGRIQMKTLTNKWY HCCCEEEEHHHHHHH	24.81	-
561	Ubiquitination	QMKTLTNKWYEEVRQ EEEHHHHHHHHHHHC	46.01	-
563	Phosphorylation	KTLTNKWYEEVRQGP EHHHHHHHHHHHCCC	12.11	21945579
571	Phosphorylation	EEVRQGPSGSEDDEQ HHHHCCCCCCCCHHH	62.87	25159151
572 (in isoform 2)	Ubiquitination	-	37.88	-
573	Phosphorylation	VRQGPSGSEDDEQEL HHCCCCCCCCHHHHC	42.04	25159151
577 (in isoform 2)	Ubiquitination	-	59.27	-
579 (in isoform 2)	Phosphorylation	-	50.41	27642862

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SL9A8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SL9A8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SL9A8_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SL9A8_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-571 AND SER-573, ANDMASS SPECTROMETRY.
PubMed: 17081983