DGKG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DGKG_HUMAN
• UniProt AC: P49619
• Protein Name: Diacylglycerol kinase gamma
• Gene Name: DGKG
• Organism: Homo sapiens (Human).
• Sequence Length: 791
• Subcellular Localization: Cytoplasm. Membrane. Can be loosely bound to the membranes.
• Protein Description: Reverses the normal flow of glycerolipid biosynthesis by phosphorylating diacylglycerol back to phosphatidic acid..
• Protein Sequence: MGEERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDPHEPISYDVFKLFMRAYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADTNIQNADNATKADEACAPDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDKLEFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGFVSLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIPGCVKTYSKAKRSGEVMQHAWVEGNSSVKCDRCHKSIKCYQSVTARHCVWCRMTFHRKCELSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGELVMQYKIIPTPGTHPLLVLVNPKSGGRQGERILRKFHYLLNPKQVFNLDNGGPTPGLNFFRDTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIPREEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQPCCTIKITHKNQAPMMMGPPQKSSFFSLRRKSRSKD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	EERWVSLTPEEFDQL CCCCCCCCHHHHHHH	22.58	24719451
23	Phosphorylation	QLQKYSEYSSKKIKD HHHHHHHHCCHHHHH	16.59	24719451
40	Phosphorylation	TEFNEGGSLKQYDPH HHCCCCCCCCCCCCC	43.16	25307156
102	Phosphorylation	ASNSEANSADTNIQN CCCHHCCCCCCCCCC	34.27	22210691
105	Phosphorylation	SEANSADTNIQNADN HHCCCCCCCCCCHHH	33.66	22210691
153	Phosphorylation	PPVPRSSSSESPVVY CCCCCCCCCCCCEEE	39.10	25307156
219	Phosphorylation	QYLEWDPTELRPILK HHHCCCHHHHHHHHH	45.22	24719451
275	Phosphorylation	GDGRHAWTMKHFKKP CCCCCCCCCHHCCCC	19.68	26657352
344	Phosphorylation	HAWVEGNSSVKCDRC EEECCCCCCCCCCCC	47.57	29978859
345	Phosphorylation	AWVEGNSSVKCDRCH EECCCCCCCCCCCCC	29.60	29978859
410	Phosphorylation	RDRPGEKSDGCVSAK CCCCCCCCCCCCCCC	34.63	23322592
415	Phosphorylation	EKSDGCVSAKGELVM CCCCCCCCCCCEEEE	28.48	23322592
424	Phosphorylation	KGELVMQYKIIPTPG CCEEEEEEEEECCCC	6.00	23322592
721	Phosphorylation	MEMGQIYTGLKSAGR HHHHHHHHHHHHHHH	37.35	24719451
737	Phosphorylation	LAQCASVTIRTNKLL HHHHEEEEEECCCCC	11.40	-
778	Phosphorylation	MMGPPQKSSFFSLRR CCCCCCCCCHHHHCC	27.42	23322592
779	Phosphorylation	MGPPQKSSFFSLRRK CCCCCCCCHHHHCCH	37.03	23322592
782	Phosphorylation	PQKSSFFSLRRKSRS CCCCCHHHHCCHHCC	20.96	29970186

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DGKG_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DGKG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DGKG_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of DGKG_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.