MYLK3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYLK3_HUMAN
• UniProt AC: Q32MK0
• Protein Name: Myosin light chain kinase 3
• Gene Name: MYLK3
• Organism: Homo sapiens (Human).
• Sequence Length: 819
• Subcellular Localization: Cytoplasm.
• Protein Description: Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity)..
• Protein Sequence: MSGTSKESLGHGGLPGLGKTCLTTMDTKLNMLNEKVDQLLHFQEDVTEKLQSMCRDMGHLERGLHRLEASRAPGPGGADGVPHIDTQAGWPEVLELVRAMQQDAAQHGARLEALFRMVAAVDRAIALVGATFQKSKVADFLMQGRVPWRRGSPGDSPEENKERVEEEGGKPKHVLSTSGVQSDAREPGEESQKADVLEGTAERLPPIRASGLGADPAQAVVSPGQGDGVPGPAQAFPGHLPLPTKVEAKAPETPSENLRTGLELAPAPGRVNVVSPSLEVAPGAGQGASSSRPDPEPLEEGTRLTPGPGPQCPGPPGLPAQARATHSGGETPPRISIHIQEMDTPGEMLMTGRGSLGPTLTTEAPAAAQPGKQGPPGTGRCLQAPGTEPGEQTPEGARELSPLQESSSPGGVKAEEEQRAGAEPGTRPSLARSDDNDHEVGALGLQQGKSPGAGNPEPEQDCAARAPVRAEAVRRMPPGAEAGSVVLDDSPAPPAPFEHRVVSVKETSISAGYEVCQHEVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLYDAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILCVNQTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEWLNNLPAKASRSKTRLKSQLLLQKYIAQRKWKKHFYVVTAANRLRKFPTSP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
152	Phosphorylation	RVPWRRGSPGDSPEE CCCCCCCCCCCCHHH	24.73	-
194	Ubiquitination	PGEESQKADVLEGTA CCCHHHHHHHHHHHH	12.42	29967540
331	Phosphorylation	ATHSGGETPPRISIH CCCCCCCCCCEEEEE	41.70	26437602
355	Phosphorylation	MLMTGRGSLGPTLTT EEECCCCCCCCCCCC	28.88	23532336
361	Phosphorylation	GSLGPTLTTEAPAAA CCCCCCCCCCCCCCC	25.68	23532336
401	Phosphorylation	PEGARELSPLQESSS CCCHHCCCCCCCCCC	20.86	27732954
406	Phosphorylation	ELSPLQESSSPGGVK CCCCCCCCCCCCCCC	24.13	29888752
407	Phosphorylation	LSPLQESSSPGGVKA CCCCCCCCCCCCCCH	39.54	29888752
408	Phosphorylation	SPLQESSSPGGVKAE CCCCCCCCCCCCCHH	36.52	14702039
425	Ubiquitination	QRAGAEPGTRPSLAR HHCCCCCCCCCHHCC	26.34	21963094
429	Phosphorylation	AEPGTRPSLARSDDN CCCCCCCHHCCCCCC	31.22	26437602
435	Ubiquitination	PSLARSDDNDHEVGA CHHCCCCCCCCCHHH	64.80	21963094
440	Ubiquitination	SDDNDHEVGALGLQQ CCCCCCCHHHHHCCC	4.95	22817900
450	Phosphorylation	LGLQQGKSPGAGNPE HHCCCCCCCCCCCCC	35.08	22210691
451	Ubiquitination	GLQQGKSPGAGNPEP HCCCCCCCCCCCCCH	39.89	21963094
460	Ubiquitination	AGNPEPEQDCAARAP CCCCCHHHCHHHCCC	62.89	29967540
507	Phosphorylation	RVVSVKETSISAGYE CEEEEEECEECCCCE	26.16	22210691
535	Ubiquitination	QVHRCTEKSTGLPLA CCEECCCCCCCCCHH	34.85	29967540
536	Phosphorylation	VHRCTEKSTGLPLAA CEECCCCCCCCCHHH	22.83	-
537	Phosphorylation	HRCTEKSTGLPLAAK EECCCCCCCCCHHHH	54.53	-
581	Phosphorylation	QLYDAFESKHSCTLV HHHHHHHCCCCEEEE	29.25	24972180
766	Ubiquitination	MSATQCLKHEWLNNL CCHHHHHHHHHHHCC	47.29	21963094
776	Ubiquitination	WLNNLPAKASRSKTR HHHCCCCCCCCCHHH	44.98	21963094
781	Ubiquitination	PAKASRSKTRLKSQL CCCCCCCHHHHHHHH	36.23	22817900
792	Ubiquitination	KSQLLLQKYIAQRKW HHHHHHHHHHHHCCC	38.30	21963094
801	Ubiquitination	IAQRKWKKHFYVVTA HHHCCCHHCEEEEEC	37.52	29967540
804	Phosphorylation	RKWKKHFYVVTAANR CCCHHCEEEEECHHH	8.17	26437602
807	Phosphorylation	KKHFYVVTAANRLRK HHCEEEEECHHHHHC	15.26	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYLK3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYLK3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYLK3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
OBSL1_HUMAN	OBSL1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.