NLRC4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NLRC4_HUMAN
• UniProt AC: Q9NPP4
• Protein Name: NLR family CARD domain-containing protein 4
• Gene Name: NLRC4
• Organism: Homo sapiens (Human).
• Sequence Length: 1024
• Subcellular Localization: Cytoplasm . Cytoplasm, cytosol . Cytoplasmic filaments.
• Protein Description: Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. [PubMed: 15107016 The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria (By similarity]
• Protein Sequence: MNFIKDNSRALIQRMGMTVIKQITDDLFVWNVLNREEVNIICCEKVEQDAARGIIHMILKKGSESCNLFLKSLKEWNYPLFQDLNGQSLFHQTSEGDLDDLAQDLKDLYHTPSFLNFYPLGEDIDIIFNLKSTFTEPVLWRKDQHHHRVEQLTLNGLLQALQSPCIIEGESGKGKSTLLQRIAMLWGSGKCKALTKFKFVFFLRLSRAQGGLFETLCDQLLDIPGTIRKQTFMAMLLKLRQRVLFLLDGYNEFKPQNCPEIEALIKENHRFKNMVIVTTTTECLRHIRQFGALTAEVGDMTEDSAQALIREVLIKELAEGLLLQIQKSRCLRNLMKTPLFVVITCAIQMGESEFHSHTQTTLFHTFYDLLIQKNKHKHKGVAASDFIRSLDHCGDLALEGVFSHKFDFELQDVSSVNEDVLLTTGLLCKYTAQRFKPKYKFFHKSFQEYTAGRRLSSLLTSHEPEEVTKGNGYLQKMVSISDITSTYSSLLRYTCGSSVEATRAVMKHLAAVYQHGCLLGLSIAKRPLWRQESLQSVKNTTEQEILKAININSFVECGIHLYQESTSKSALSQEFEAFFQGKSLYINSGNIPDYLFDFFEHLPNCASALDFIKLDFYGGAMASWEKAAEDTGGIHMEEAPETYIPSRAVSLFFNWKQEFRTLEVTLRDFSKLNKQDIRYLGKIFSSATSLRLQIKRCAGVAGSLSLVLSTCKNIYSLMVEASPLTIEDERHITSVTNLKTLSIHDLQNQRLPGGLTDSLGNLKNLTKLIMDNIKMNEEDAIKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYLEKDGNEALHELIDRMNVLEQLTALMLPWGCDVQGSLSSLLKHLEEVPQLVKLGLKNWRLTDTEIRILGAFFGKNPLKNFQQLNLAGNRVSSDGWLAFMGVFENLKQLVFFDFSTKEFLPDPALVRKLSQVLSKLTFLQEARLVGWQFDDDDLSVITGAFKLVTA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Methylation	---MNFIKDNSRALI ---CCCCCHHHHHHH	46.87	115974069
142	Ubiquitination	TEPVLWRKDQHHHRV CCCCCCCCCCCCHHH	50.59	25015289
188	Phosphorylation	RIAMLWGSGKCKALT HHHHHHCCCHHHHCH	24.40	30631047
315	Acetylation	LIREVLIKELAEGLL HHHHHHHHHHHHHHH	42.38	7468655
445	Phosphorylation	KYKFFHKSFQEYTAG CCCCHHHHHHHHHCH	24.48	28857561
489	Phosphorylation	DITSTYSSLLRYTCG HHHHHHHHHHHHHCC	22.47	24719451
533	Phosphorylation	RPLWRQESLQSVKNT CCCCCHHHHHHCCCC	24.30	26657352
540	Phosphorylation	SLQSVKNTTEQEILK HHHHCCCCCHHHHHH	26.45	27794612
541	Phosphorylation	LQSVKNTTEQEILKA HHHCCCCCHHHHHHH	45.10	27794612
553	Phosphorylation	LKAININSFVECGIH HHHHCCCHHHHCCCE	27.20	25404012
562	Phosphorylation	VECGIHLYQESTSKS HHCCCEECCCCCCHH	8.96	25404012
565	Phosphorylation	GIHLYQESTSKSALS CCEECCCCCCHHHHH	23.58	25404012
566	Phosphorylation	IHLYQESTSKSALSQ CEECCCCCCHHHHHH	39.15	25404012
567	Phosphorylation	HLYQESTSKSALSQE EECCCCCCHHHHHHH	33.61	25404012
736	Phosphorylation	ERHITSVTNLKTLSI CCCEEEEECCCEEEH	34.30	-
898	Phosphorylation	DVQGSLSSLLKHLEE CCHHCHHHHHHHHHH	42.91	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NLRC4_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
533	S	Phosphorylation	PRKCD phosphorylates Ser-533 in vitro.	-
533	S	Phosphorylation	Phosphorylated at Ser-533 following infection of macrophages with S.typhimurium (Salmonella).	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NLRC4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NLRC4_HUMAN	NLRC4	physical	15107016
NOD2_HUMAN	NOD2	physical	15107016
XK_HUMAN	XK	physical	15107016
NOD1_HUMAN	NOD1	physical	15107016
BIRC1_HUMAN	NAIP	physical	15107016
NLRP3_HUMAN	NLRP3	physical	15107016
NLRP1_HUMAN	NLRP1	physical	11472070
BCL10_HUMAN	BCL10	physical	11472070
NLRC4_HUMAN	NLRC4	physical	11472070
CASP1_HUMAN	CASP1	physical	11472070
NOD2_HUMAN	NOD2	physical	11472070
ASC_HUMAN	PYCARD	physical	11374873
NLRC4_HUMAN	NLRC4	physical	20085538
PRS8_HUMAN	PSMC5	physical	20085538
PRS8_HUMAN	PSMC5	physical	27974463

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.