NOD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NOD1_HUMAN
• UniProt AC: Q9Y239
• Protein Name: Nucleotide-binding oligomerization domain-containing protein 1
• Gene Name: NOD1
• Organism: Homo sapiens (Human).
• Sequence Length: 953
• Subcellular Localization: Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Detected in the cytoplasm and at the cell membrane. Following bacterial infection, localizes to bacterial entry sites in the cell membrane. Recruited to the basolateral and ap
• Protein Description: Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection..
• Protein Sequence: MEEQGHSEMEIIPSESHPHIQLLKSNRELLVTHIRNTQCLVDNLLKNDYFSAEDAEIVCACPTQPDKVRKILDLVQSKGEEVSEFFLYLLQQLADAYVDLRPWLLEIGFSPSLLTQSKVVVNTDPVSRYTQQLRHHLGRDSKFVLCYAQKEELLLEEIYMDTIMELVGFSNESLGSLNSLACLLDHTTGILNEQGETIFILGDAGVGKSMLLQRLQSLWATGRLDAGVKFFFHFRCRMFSCFKESDRLCLQDLLFKHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSSCPWEPAHPLVLLANLLSGKLLKGASKLLTARTGIEVPRQFLRKKVLLRGFSPSHLRAYARRMFPERALQDRLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQLPDCTMTLTDVFLLVTEVHLNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQEEVQASGLQERDMQLGFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGTQELLRFFQEWMPPAGAATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLSKAKQKLLRHLVPAAALRRKRKALWAHLFSSLRGYLKSLPRVQVESFNQVQAMPTFIWMLRCIYETQSQKVGQLAARGICANYLKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGVRELQPCFSRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGNLIKPEEAKVYEDEKRIICF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
129	Phosphorylation	NTDPVSRYTQQLRHH CCCHHHHHHHHHHHH	11.03	29978859
130	Phosphorylation	TDPVSRYTQQLRHHL CCHHHHHHHHHHHHC	14.55	29978859
141	Phosphorylation	RHHLGRDSKFVLCYA HHHCCCCCCEEEEEE	27.00	29978859
217	Phosphorylation	MLLQRLQSLWATGRL HHHHHHHHHHHHCCC	30.39	-
249	S-palmitoylation	FKESDRLCLQDLLFK CHHHHHHHHHHHHHH	3.14	29575903
328	Ubiquitination	KLLKGASKLLTARTG CHHHHHHHHHHHCCC	47.16	-
334	Phosphorylation	SKLLTARTGIEVPRQ HHHHHHCCCCCCCHH	39.79	-
597	Phosphorylation	LFLCGLLSKAKQKLL HHHHHHHHHHHHHHH	35.29	24719451
627	Phosphorylation	LWAHLFSSLRGYLKS HHHHHHHHHHHHHHC	18.10	24719451
754	Ubiquitination	VLSEELTKYKIVTYL ECCHHHHHCCEEEEE	58.11	-
784	Ubiquitination	TKILDECKGLTHLKL HHHHHHCCCCCEEEC	55.71	-
797	Phosphorylation	KLGKNKITSEGGKYL ECCCCEEECCCHHEE	23.49	24719451
798	Phosphorylation	LGKNKITSEGGKYLA CCCCEEECCCHHEEE	37.40	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	RNF34	Q969K3	PMID:25012219

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NOD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NOD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NOD1_HUMAN	NOD1	physical	10329646
CASP1_HUMAN	CASP1	physical	10329646
CASP2_HUMAN	CASP2	physical	10329646
CASP4_HUMAN	CASP4	physical	10329646
CASP8_HUMAN	CASP8	physical	10329646
CASP9_HUMAN	CASP9	physical	10329646
RIPK2_HUMAN	RIPK2	physical	10329646
CFLAR_HUMAN	CFLAR	physical	10329646
HS90A_HUMAN	HSP90AA1	physical	17435760
SGT1_HUMAN	SUGT1	physical	17435760
CSN6_HUMAN	COPS6	physical	17337451
SGT1_HUMAN	SUGT1	physical	17420470
HS90A_HUMAN	HSP90AA1	physical	17420470
PSA7_HUMAN	PSMA7	physical	23839082
SOX8_HUMAN	SOX8	physical	21988832
RNF34_HUMAN	RNF34	physical	25012219
A16L1_HUMAN	ATG16L1	physical	19898471
NOD2_HUMAN	NOD2	physical	19898471
RIPK2_HUMAN	RIPK2	physical	23300079
A16L1_HUMAN	ATG16L1	physical	23300079
UBC_HUMAN	UBC	physical	23300079
NOD1_HUMAN	NOD1	physical	23300079

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.