NOD2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NOD2_HUMAN
• UniProt AC: Q9HC29
• Protein Name: Nucleotide-binding oligomerization domain-containing protein 2
• Gene Name: NOD2
• Organism: Homo sapiens (Human).
• Sequence Length: 1040
• Subcellular Localization: Cytoplasm . Membrane . Mitochondrion . Basolateral cell membrane .
• Protein Description: Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages. [PubMed: 18511561 Component of an autophagy-mediated antibacterial pathway together with ATG16L1]
• Protein Sequence: MGEEGGSASHDEEERASVLLGHSPGCEMCSQEAFQAQRSQLVELLVSGSLEGFESVLDWLLSWEVLSWEDYEGFHLLGQPLSHLARRLLDTVWNKGTWACQKLIAAAQEAQADSQSPKLHGCWDPHSLHPARDLQSHRPAIVRRLHSHVENMLDLAWERGFVSQYECDEIRLPIFTPSQRARRLLDLATVKANGLAAFLLQHVQELPVPLALPLEAATCKKYMAKLRTTVSAQSRFLSTYDGAETLCLEDIYTENVLEVWADVGMAGPPQKSPATLGLEELFSTPGHLNDDADTVLVVGEAGSGKSTLLQRLHLLWAAGQDFQEFLFVFPFSCRQLQCMAKPLSVRTLLFEHCCWPDVGQEDIFQLLLDHPDRVLLTFDGFDEFKFRFTDRERHCSPTDPTSVQTLLFNLLQGNLLKNARKVVTSRPAAVSAFLRKYIRTEFNLKGFSEQGIELYLRKRHHEPGVADRLIRLLQETSALHGLCHLPVFSWMVSKCHQELLLQEGGSPKTTTDMYLLILQHFLLHATPPDSASQGLGPSLLRGRLPTLLHLGRLALWGLGMCCYVFSAQQLQAAQVSPDDISLGFLVRAKGVVPGSTAPLEFLHITFQCFFAAFYLALSADVPPALLRHLFNCGRPGNSPMARLLPTMCIQASEGKDSSVAALLQKAEPHNLQITAAFLAGLLSREHWGLLAECQTSEKALLRRQACARWCLARSLRKHFHSIPPAAPGEAKSVHAMPGFIWLIRSLYEMQEERLARKAARGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGVCKALYLRDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTILEVWLRGNTFSLEEVDKLGCRDTRLLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
189	Phosphorylation	RRLLDLATVKANGLA HHHHHHHCHHHCHHH	29.81	24888630
238	Phosphorylation	SAQSRFLSTYDGAET HHHHHHHHHCCCCCE	23.39	-
239	Phosphorylation	AQSRFLSTYDGAETL HHHHHHHHCCCCCEE	27.98	-
402	Phosphorylation	CSPTDPTSVQTLLFN CCCCCCHHHHHHHHH	20.02	-
424	Phosphorylation	KNARKVVTSRPAAVS HHCHHHHHCCHHHHH	23.23	-
425	Phosphorylation	NARKVVTSRPAAVSA HCHHHHHCCHHHHHH	25.34	24719451
477	Phosphorylation	IRLLQETSALHGLCH HHHHHHHHHHHHHCC	28.25	-
493	Phosphorylation	PVFSWMVSKCHQELL HHHHHHHHHHHHHHH	17.29	-
628 (in isoform 2)	Ubiquitination	-	34.44	21906983
655 (in isoform 1)	Ubiquitination	-	50.84	21906983
655	Ubiquitination	CIQASEGKDSSVAAL EEECCCCCCHHHHHH	50.84	2190698
714	Phosphorylation	ARWCLARSLRKHFHS HHHHHHHHHHHHHHC	27.24	23312004
717	Acetylation	CLARSLRKHFHSIPP HHHHHHHHHHHCCCC	56.78	11790057
731	Acetylation	PAAPGEAKSVHAMPG CCCCCCCCCHHCCCH	49.02	11790067
745	Phosphorylation	GFIWLIRSLYEMQEE HHHHHHHHHHHHHHH	28.45	22673903
747	Phosphorylation	IWLIRSLYEMQEERL HHHHHHHHHHHHHHH	15.59	22673903
882	Phosphorylation	ALRLGNNYITAAGAQ HHCCCCCEEEHHHHH	12.03	24043423
884	Phosphorylation	RLGNNYITAAGAQVL CCCCCEEEHHHHHHH	10.49	24043423
899	Phosphorylation	AEGLRGNTSLQFLGF HHHCCCCCCEEEEEE	33.37	24043423
900	Phosphorylation	EGLRGNTSLQFLGFW HHCCCCCCEEEEEEC	24.95	24043423
983	Phosphorylation	AEGLKKNSSLKILKL HHHHHCCCCCEEEEE	46.02	-
984	Phosphorylation	EGLKKNSSLKILKLS HHHHCCCCCEEEEEC	42.97	-
1022	Phosphorylation	EVWLRGNTFSLEEVD EEEHHCCCCCHHHHH	19.88	-
1024	Phosphorylation	WLRGNTFSLEEVDKL EHHCCCCCHHHHHHH	32.60	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NOD2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NOD2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NOD2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RIPK2_HUMAN	RIPK2	physical	11087742
RIPK2_HUMAN	RIPK2	physical	19592251
RIPK2_HUMAN	RIPK2	physical	15620648
RIPK2_HUMAN	RIPK2	physical	21123652
RIPK2_HUMAN	RIPK2	physical	22607974
BIRC2_HUMAN	BIRC2	physical	22607974
BIRC3_HUMAN	BIRC3	physical	22607974
NAT16_HUMAN	NAT16	physical	22607974
XIAP_HUMAN	XIAP	physical	22607974
NEMO_HUMAN	IKBKG	physical	22607974
RIPK1_HUMAN	RIPK1	physical	22607974
RNF31_HUMAN	RNF31	physical	22607974
HOIL1_HUMAN	RBCK1	physical	22607974
SHRPN_HUMAN	SHARPIN	physical	22607974
GALT2_HUMAN	GALNT2	physical	21699783
FIS1_HUMAN	FIS1	physical	21699783
TLE1_HUMAN	TLE1	physical	21699783
VIME_HUMAN	VIM	physical	21699783
KAT5_HUMAN	KAT5	physical	21699783
2A5E_HUMAN	PPP2R5E	physical	21699783
CASPC_HUMAN	CASP12	physical	18329614
TRI27_HUMAN	TRIM27	physical	22829933
CSN6_HUMAN	COPS6	physical	17337451
RIPK2_HUMAN	RIPK2	physical	21097508
TRAF4_HUMAN	TRAF4	physical	21097508
M3K7_HUMAN	MAP3K7	physical	17965022
M3K7_HUMAN	MAP3K7	physical	15075345
M3K7_HUMAN	MAP3K7	physical	17348859
NOD2_HUMAN	NOD2	physical	23437331
RNF31_HUMAN	RNF31	physical	23818254
HOIL1_HUMAN	RBCK1	physical	23818254
SHRPN_HUMAN	SHARPIN	physical	23818254
A16L1_HUMAN	ATG16L1	physical	19898471
NOD1_HUMAN	NOD1	physical	19898471
UBC_HUMAN	UBC	physical	23300079
IRGM_HUMAN	IRGM	physical	25891078
CYLD_HUMAN	CYLD	physical	26670046
RNF31_HUMAN	RNF31	physical	26670046
HOIL1_HUMAN	RBCK1	physical	26670046
RIPK2_HUMAN	RIPK2	physical	26670046
SHRPN_HUMAN	SHARPIN	physical	26670046
TNAP3_HUMAN	TNFAIP3	physical	26670046

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 186580: Blau syndrome (BLAUS)
• 266600: Inflammatory bowel disease 1 (IBD1)
• 609464: Sarcoidosis early-onset (EOS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.