| UniProt ID | CASPC_HUMAN | |
|---|---|---|
| UniProt AC | Q6UXS9 | |
| Protein Name | Inactive caspase-12 | |
| Gene Name | CASP12 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 341 | |
| Subcellular Localization | ||
| Protein Description | Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF.. | |
| Protein Sequence | MADEKPSNGVLVHMVKLLIKTFLDGIFDDLMENNVLNTDEIHLIGKCLKFVVSNAENLVDDITETAQTAGKIFREHLWNSKKQLSSDISSDGEREANMPGLNIRNKEFNYLHNRNGSELDLLGMRDLLENLGYSVVIKENLTAQEMETALRQFAAHPEHQSSDSTFLVFMSHSILNGICGTKHWDQEPDVLHDDTIFEIFNNRNCQSLKDKPKVIIMQACRGNGAGIVWFTTDSGKAGADTHGRLLQGNICNDAVTKAHVEKDFIAFKSSTPHNVSWRHETNGSVFISQIIYYFREYSWSHHLEEIFQKVQHSFETPNILTQLPTIERLSMTRYFYLFPGN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 80 (in isoform 2) | Phosphorylation | - | 29.64 | 26657352 | |
| 85 | Phosphorylation | WNSKKQLSSDISSDG HCCCHHHCCCCCCCC | 24.38 | - | |
| 86 (in isoform 2) | Phosphorylation | - | 47.78 | 26657352 | |
| 90 | Phosphorylation | QLSSDISSDGEREAN HHCCCCCCCCCHHHC | 50.39 | - | |
| 97 (in isoform 2) | Phosphorylation | - | 32.21 | 26657352 | |
| 142 | Phosphorylation | VVIKENLTAQEMETA EEEECCCCHHHHHHH | 37.57 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CASPC_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CASPC_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CASPC_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CASPC_HUMAN | CASP12 | physical | 11278723 | |
| RIPK2_HUMAN | RIPK2 | physical | 18329614 | |
| CRYAB_HUMAN | CRYAB | physical | 23074197 | |
| XIAP_HUMAN | XIAP | physical | 23074197 | |
| CASPC_HUMAN | CASP12 | physical | 12097332 | |
| CASP9_HUMAN | CASP9 | physical | 12097332 | |
| MAGA3_HUMAN | MAGEA3 | physical | 12097332 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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