MAGA3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAGA3_HUMAN
• UniProt AC: P43357
• Protein Name: Melanoma-associated antigen 3
• Gene Name: MAGEA3
• Organism: Homo sapiens (Human).
• Sequence Length: 314
• Protein Description: Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes..
• Protein Sequence: MPLEQRSQHCKPEEGLEARGEALGLVGAQAPATEEQEAASSSSTLVEVTLGEVPAAESPDPPQSPQGASSLPTTMNYPLWSQSYEDSSNQEEEGPSTFPDLESEFQAALSRKVAELVHFLLLKYRAREPVTKAEMLGSVVGNWQYFFPVIFSKASSSLQLVFGIELMEVDPIGHLYIFATCLGLSYDGLLGDNQIMPKAGLLIIVLAIIAREGDCAPEEKIWEELSVLEVFEGREDSILGDPKKLLTQHFVQENYLEYRQVPGSDPACYEFLWGPRALVETSYVKVLHHMVKISGGPHISYPPLHEWVLREGEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MPLEQRSQHCKPEE -CCHHHHHHCCCHHH	24.78	26434776
11	Sumoylation	EQRSQHCKPEEGLEA HHHHHCCCHHHHHHH	54.03	-
11	Sumoylation	EQRSQHCKPEEGLEA HHHHHCCCHHHHHHH	54.03	-
11	Ubiquitination	EQRSQHCKPEEGLEA HHHHHCCCHHHHHHH	54.03	-
112	Ubiquitination	FQAALSRKVAELVHF HHHHHHHHHHHHHHH	42.28	23503661
124	Phosphorylation	VHFLLLKYRAREPVT HHHHHHHHHCCCCCC	14.96	-
132	Ubiquitination	RAREPVTKAEMLGSV HCCCCCCHHHHHHHH	42.45	21987572
152	Phosphorylation	YFFPVIFSKASSSLQ HHHHHHHCCCCCCHH	19.05	24719451
220	Ubiquitination	GDCAPEEKIWEELSV CCCCCHHHHHHHHCH	52.00	22817900
237	Phosphorylation	VFEGREDSILGDPKK HHCCCCCCCCCCHHH	18.24	29449344
243	Ubiquitination	DSILGDPKKLLTQHF CCCCCCHHHHHHHHH	61.87	22817900
244	Ubiquitination	SILGDPKKLLTQHFV CCCCCHHHHHHHHHH	54.86	21906983
247	Phosphorylation	GDPKKLLTQHFVQEN CCHHHHHHHHHHHHH	30.36	24719451
258	Phosphorylation	VQENYLEYRQVPGSD HHHHCHHHHCCCCCC	12.07	24719451
285	Ubiquitination	LVETSYVKVLHHMVK HHHHHHHHHHHHHHC	30.74	22817900
292	Ubiquitination	KVLHHMVKISGGPHI HHHHHHHCCCCCCCC	24.47	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	DCAF12	Q5T6F0	PMID:31267705

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAGA3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAGA3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TIF1B_HUMAN	TRIM28	physical	20864041
TIF1B_HUMAN	TRIM28	physical	21277283
CASPC_HUMAN	CASP12	physical	12097332

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.