| UniProt ID | BIRC3_HUMAN | |
|---|---|---|
| UniProt AC | Q13489 | |
| Protein Name | Baculoviral IAP repeat-containing protein 3 | |
| Gene Name | BIRC3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 604 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.. | |
| Protein Sequence | MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Phosphorylation | -MNIVENSIFLSNLM -CCCHHHHHHHHHHH | 10.95 | 20044836 | |
| 11 | Phosphorylation | VENSIFLSNLMKSAN HHHHHHHHHHHHHCC | 19.71 | 20044836 | |
| 57 | Phosphorylation | LARAGFYYTGVNDKV HHHCCCEECCCCCCE | 8.51 | 27067055 | |
| 58 | Phosphorylation | ARAGFYYTGVNDKVK HHCCCEECCCCCCEE | 24.23 | 27067055 | |
| 63 | Ubiquitination | YYTGVNDKVKCFCCG EECCCCCCEEEEECC | 38.09 | - | |
| 139 | Phosphorylation | GYFRGSYSNSPSNPV CCCCCCCCCCCCCCC | 32.31 | 30576142 | |
| 141 | Phosphorylation | FRGSYSNSPSNPVNS CCCCCCCCCCCCCCC | 24.62 | 30576142 | |
| 143 | Phosphorylation | GSYSNSPSNPVNSRA CCCCCCCCCCCCCCC | 54.29 | 30576142 | |
| 160 | Phosphorylation | DFSALMRSSYHCAMN CHHHHHHHHHHHHHC | 22.68 | 27251275 | |
| 161 | Phosphorylation | FSALMRSSYHCAMNN HHHHHHHHHHHHHCC | 14.45 | 27251275 | |
| 195 | Phosphorylation | DLAKAGFYYIGPGDR HHHHCCCEEECCCCC | 8.02 | 28152594 | |
| 196 | Phosphorylation | LAKAGFYYIGPGDRV HHHCCCEEECCCCCE | 9.35 | 28152594 | |
| 211 | Ubiquitination | ACFACGGKLSNWEPK EEEECCCCCCCCCCC | 33.74 | 21890473 | |
| 218 | Ubiquitination | KLSNWEPKDNAMSEH CCCCCCCCCCHHHHH | 52.69 | 29967540 | |
| 231 | Ubiquitination | EHLRHFPKCPFIENQ HHHHHCCCCCCHHHH | 54.30 | 25015289 | |
| 245 | Phosphorylation | QLQDTSRYTVSNLSM HHCCCCCCEECCHHH | 15.97 | 24719451 | |
| 246 | Phosphorylation | LQDTSRYTVSNLSMQ HCCCCCCEECCHHHH | 19.15 | 24719451 | |
| 248 | Phosphorylation | DTSRYTVSNLSMQTH CCCCCEECCHHHHHC | 25.01 | - | |
| 254 | Phosphorylation | VSNLSMQTHAARFKT ECCHHHHHCHHHHHH | 12.58 | - | |
| 260 | Ubiquitination | QTHAARFKTFFNWPS HHCHHHHHHHHCCCH | 38.58 | - | |
| 278 | Phosphorylation | VNPEQLASAGFYYVG CCHHHHHHCCEEEEC | 37.20 | - | |
| 396 | Ubiquitination | GFSRSLVKQTVQRKI CCCHHHHHHHHHHHH | 45.61 | 29967540 | |
| 398 | Phosphorylation | SRSLVKQTVQRKILA CHHHHHHHHHHHHHH | 16.94 | - | |
| 402 | Ubiquitination | VKQTVQRKILATGEN HHHHHHHHHHHCCCC | 25.61 | 29967540 | |
| 439 | Ubiquitination | RERATEEKESNDLLL HHHHHHHHHHCCEEE | 61.28 | 29967540 | |
| 485 | Ubiquitination | EHDVIKQKTQTSLQA HCHHHHHHHHHHHHH | 37.28 | 29967540 | |
| 540 | Phosphorylation | YIPTEDVSDLPVEEQ CCCCCCHHCCCHHHH | 45.83 | 27251275 | |
| 587 | Ubiquitination | DCAPSLRKCPICRST CCCCHHHCCCCCHHH | 50.05 | - | |
| 596 | Ubiquitination | PICRSTIKGTVRTFL CCCHHHCCCHHHHHC | 48.93 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| - | K | Ubiquitination | E3 ubiquitin ligase | TANK | Q92844 | PMID:22199232 |
| - | K | Ubiquitination | E3 ubiquitin ligase | TRAF2 | Q12933 | PMID:11907583 |
| - | K | Ubiquitination | E3 ubiquitin ligase | BIRC3 | Q13489 | PMID:18939944 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BIRC3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BIRC3_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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