dbPTM

PELI1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PELI1_HUMAN
UniProt AC	Q96FA3
Protein Name	E3 ubiquitin-protein ligase pellino homolog 1
Gene Name	PELI1
Organism	Homo sapiens (Human).
Sequence Length	418
Subcellular Localization
Protein Description	E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation..
Protein Sequence	MFSPDQENHPSKAPVKYGELIVLGYNGSLPNGDRGRRKSRFALFKRPKANGVKPSTVHIACTPQAAKAISNKDQHSISYTLSRAQTVVVEYTHDSNTDMFQIGRSTESPIDFVVTDTVPGSQSNSDTQSVQSTISRFACRIICERNPPFTARIYAAGFDSSKNIFLGEKAAKWKTSDGQMDGLTTNGVLVMHPRNGFTEDSKPGIWREISVCGNVFSLRETRSAQQRGKMVEIETNQLQDGSLIDLCGATLLWRTAEGLSHTPTVKHLEALRQEINAARPQCPVGFNTLAFPSMKRKDVVDEKQPWVYLNCGHVHGYHNWGNKEERDGKDRECPMCRSVGPYVPLWLGCEAGFYVDAGPPTHAFSPCGHVCSEKTTAYWSQIPLPHGTHTFHAACPFCAHQLAGEQGYIRLIFQGPLD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MFSPDQENHP -----CCCCCCCCCC	26.69	-
12	Acetylation	DQENHPSKAPVKYGE CCCCCCCCCCCEECC	62.25	25953088
12	Ubiquitination	DQENHPSKAPVKYGE CCCCCCCCCCCEECC	62.25	-
16	Ubiquitination	HPSKAPVKYGELIVL CCCCCCCEECCEEEE	46.62	-
17	Phosphorylation	PSKAPVKYGELIVLG CCCCCCEECCEEEEE	18.96	22461510
48	Acetylation	FALFKRPKANGVKPS EEEEECCCCCCCCCC	59.52	7965515
53	Acetylation	RPKANGVKPSTVHIA CCCCCCCCCCEEEEE	34.35	7965525
70	Phosphorylation	PQAAKAISNKDQHSI HHHHHHHCCCCHHHH	42.56	19264966
76	Phosphorylation	ISNKDQHSISYTLSR HCCCCHHHHEEEECC	13.95	27470641
78	Phosphorylation	NKDQHSISYTLSRAQ CCCHHHHEEEECCCE	18.32	23312004
79	Phosphorylation	KDQHSISYTLSRAQT CCHHHHEEEECCCEE	15.27	23312004
80	Phosphorylation	DQHSISYTLSRAQTV CHHHHEEEECCCEEE	16.09	19264966
82	Phosphorylation	HSISYTLSRAQTVVV HHHEEEECCCEEEEE	20.12	19264966
86	Phosphorylation	YTLSRAQTVVVEYTH EEECCCEEEEEEEEC	17.81	19264966
115	Phosphorylation	SPIDFVVTDTVPGSQ CCCCEEEEECCCCCC	22.20	24719451
117	Phosphorylation	IDFVVTDTVPGSQSN CCEEEEECCCCCCCC	21.16	24719451
125	Phosphorylation	VPGSQSNSDTQSVQS CCCCCCCCCCHHHHH	47.48	21204785
127	Phosphorylation	GSQSNSDTQSVQSTI CCCCCCCCHHHHHHH	23.67	27470641
129	Phosphorylation	QSNSDTQSVQSTISR CCCCCCHHHHHHHHH	24.98	24719451
154	Phosphorylation	PPFTARIYAAGFDSS CCCEEEEEEECCCCC	5.71	28270605
160	Phosphorylation	IYAAGFDSSKNIFLG EEEECCCCCCCEECC	40.73	28270605
161	Phosphorylation	YAAGFDSSKNIFLGE EEECCCCCCCEECCC	31.40	28270605
162	Ubiquitination	AAGFDSSKNIFLGEK EECCCCCCCEECCCC	59.00	-
169	Ubiquitination	KNIFLGEKAAKWKTS CCEECCCCCCCCCCC	52.42	19264966
202	Sumoylation	NGFTEDSKPGIWREI CCCCCCCCCCCCEEE	60.63	-
202	Ubiquitination	NGFTEDSKPGIWREI CCCCCCCCCCCCEEE	60.63	19264966
202	Sumoylation	NGFTEDSKPGIWREI CCCCCCCCCCCCEEE	60.63	-
264	Phosphorylation	EGLSHTPTVKHLEAL CCCCCCCHHHHHHHH	43.26	28857561
266	Sumoylation	LSHTPTVKHLEALRQ CCCCCHHHHHHHHHH	44.97	-
266	Ubiquitination	LSHTPTVKHLEALRQ CCCCCHHHHHHHHHH	44.97	21890473
266	Sumoylation	LSHTPTVKHLEALRQ CCCCCHHHHHHHHHH	44.97	-
288	Phosphorylation	QCPVGFNTLAFPSMK CCCCCCCCCCCCCCC	19.73	27470641
293	Phosphorylation	FNTLAFPSMKRKDVV CCCCCCCCCCCCCCC	30.40	27470641
295	Sumoylation	TLAFPSMKRKDVVDE CCCCCCCCCCCCCCC	61.71	-
295	Sumoylation	TLAFPSMKRKDVVDE CCCCCCCCCCCCCCC	61.71	-
297	Sumoylation	AFPSMKRKDVVDEKQ CCCCCCCCCCCCCCC	49.73	-
297	Sumoylation	AFPSMKRKDVVDEKQ CCCCCCCCCCCCCCC	49.73	-
303	Sumoylation	RKDVVDEKQPWVYLN CCCCCCCCCCEEEEE	58.14	-
303	Sumoylation	RKDVVDEKQPWVYLN CCCCCCCCCCEEEEE	58.14	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
70	S	Phosphorylation	Kinase	IRAK4	Q9NWZ3	PSP
70	S	Phosphorylation	Kinase	IRAK1	P51617	PSP
76	S	Phosphorylation	Kinase	TBK1	Q9UHD2	PSP
76	S	Phosphorylation	Kinase	IRAK4	Q9NWZ3	PSP
76	S	Phosphorylation	Kinase	IRAK1	P51617	PSP
76	S	Phosphorylation	Kinase	IKBKE	Q14164	GPS
78	S	Phosphorylation	Kinase	IRAK4	Q9NWZ3	PSP
78	S	Phosphorylation	Kinase	IRAK1	P51617	PSP
80	T	Phosphorylation	Kinase	TBK1	Q9UHD2	PSP
80	T	Phosphorylation	Kinase	IKBKE	Q14164	GPS
80	T	Phosphorylation	Kinase	IRAK1	P51617	PSP
80	T	Phosphorylation	Kinase	IRAK4	Q9NWZ3	PSP
82	S	Phosphorylation	Kinase	IRAK1	P51617	PSP
82	S	Phosphorylation	Kinase	IRAK4	Q9NWZ3	PSP
86	T	Phosphorylation	Kinase	IRAK1	P51617	PSP
86	T	Phosphorylation	Kinase	IRAK4	Q9NWZ3	PSP
125	S	Phosphorylation	Kinase	IRAK1	P51617	PSP
127	T	Phosphorylation	Kinase	IRAK4	Q9NWZ3	PSP
127	T	Phosphorylation	Kinase	IRAK1	P51617	PSP
288	T	Phosphorylation	Kinase	IRAK4	Q9NWZ3	PSP
288	T	Phosphorylation	Kinase	IKBKE	Q14164	GPS
288	T	Phosphorylation	Kinase	IRAK1	P51617	PSP
288	T	Phosphorylation	Kinase	TBK1	Q9UHD2	PSP
293	S	Phosphorylation	Kinase	IRAK1	P51617	PSP
293	S	Phosphorylation	Kinase	IRAK4	Q9NWZ3	PSP
293	S	Phosphorylation	Kinase	TBK1	Q9UHD2	PSP
293	S	Phosphorylation	Kinase	IKBKE	Q14164	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	IRAK4	Q9NWZ3	PMID:17675297
-	K	Ubiquitination	E3 ubiquitin ligase	IRAK1	P51617	PMID:17675297

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PELI1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PELI1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IRAK1_HUMAN	IRAK1	physical	17675297
RIPK1_HUMAN	RIPK1	physical	19734906
IRAK1_HUMAN	IRAK1	physical	19081057
UBC9_HUMAN	UBE2I	physical	21120624
UBC_HUMAN	UBC	physical	19264966
UBC_HUMAN	UBC	physical	21204785
IRAK1_HUMAN	IRAK1	physical	12496252
IRAK4_HUMAN	IRAK4	physical	12496252
TRAF6_HUMAN	TRAF6	physical	12496252
IL1R1_HUMAN	IL1R1	physical	12496252
SMAD6_HUMAN	SMAD6	physical	16951688
IRAK1_HUMAN	IRAK1	physical	16951688
MYD88_HUMAN	MYD88	physical	16951688
TRAF6_HUMAN	TRAF6	physical	16951688
IRAK4_HUMAN	IRAK4	physical	16951688
IRAK1_HUMAN	IRAK1	physical	15917247
TRAF6_HUMAN	TRAF6	physical	12804775
NR2C2_HUMAN	NR2C2	physical	12804775
UBE2N_HUMAN	UBE2N	physical	21204785
UB2V1_HUMAN	UBE2V1	physical	21204785
UB2V1_HUMAN	UBE2V1	physical	19734906
UB2D1_HUMAN	UBE2D1	physical	19264966
UB2D2_HUMAN	UBE2D2	physical	19264966
DEAF1_HUMAN	DEAF1	physical	23846693
BCL6_HUMAN	BCL6	physical	25295537
IRAK1_HUMAN	IRAK1	physical	26082489
TBK1_HUMAN	TBK1	physical	26082489
BIRC3_HUMAN	BIRC3	physical	27248820

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PELI1_HUMAN

Related Literatures of Post-Translational Modification