dbPTM

MYD88_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MYD88_HUMAN
UniProt AC	Q99836
Protein Name	Myeloid differentiation primary response protein MyD88
Gene Name	MYD88 {ECO:0000312\|HGNC:HGNC:7562}
Organism	Homo sapiens (Human).
Sequence Length	296
Subcellular Localization	Cytoplasm . Nucleus .
Protein Description	Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. [PubMed: 15361868]
Protein Sequence	MAAGGPGAGSAAPVSSTSSLPLAALNMRVRRRLSLFLNVRTQVAADWTALAEEMDFEYLEIRQLETQADPTGRLLDAWQGRPGASVGRLLELLTKLGRDDVLLELGPSIEEDCQKYILKQQQEEAEKPLQVAAVDSSVPRTAELAGITTLDDPLGHMPERFDAFICYCPSDIQFVQEMIRQLEQTNYRLKLCVSDRDVLPGTCVWSIASELIEKRCRRMVVVVSDDYLQSKECDFQTKFALSLSPGAHQKRLIPIKYKAMKKEFPSILRFITVCDYTNPCTKSWFWTRLAKALSLP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	AGGPGAGSAAPVSST CCCCCCCCCCCCCCC	22.26	27690223
15	Phosphorylation	AGSAAPVSSTSSLPL CCCCCCCCCCCCCCH	27.17	27690223
16	Phosphorylation	GSAAPVSSTSSLPLA CCCCCCCCCCCCCHH	32.32	27690223
17	Phosphorylation	SAAPVSSTSSLPLAA CCCCCCCCCCCCHHH	18.15	23532336
18	Phosphorylation	AAPVSSTSSLPLAAL CCCCCCCCCCCHHHH	31.65	23532336
19	Phosphorylation	APVSSTSSLPLAALN CCCCCCCCCCHHHHC	33.81	27690223
34	Phosphorylation	MRVRRRLSLFLNVRT HHHHHHHHHHHCCCH	18.44	28450419
74	Ubiquitination	QADPTGRLLDAWQGR CCCCCCCCCHHHCCC	5.55	21890473
95	Ubiquitination	RLLELLTKLGRDDVL HHHHHHHHHCCCHHH	49.25	21890473
108	Ubiquitination	VLLELGPSIEEDCQK HHHHCCCCHHHHHHH	40.61	21890473
108	Ubiquitination	VLLELGPSIEEDCQK HHHHCCCCHHHHHHH	40.61	-
108	Ubiquitination	VLLELGPSIEEDCQK HHHHCCCCHHHHHHH	40.61	21890473
108	Ubiquitination	VLLELGPSIEEDCQK HHHHCCCCHHHHHHH	40.61	21890473
108	Ubiquitination	VLLELGPSIEEDCQK HHHHCCCCHHHHHHH	40.61	21906983
108	Ubiquitination	VLLELGPSIEEDCQK HHHHCCCCHHHHHHH	40.61	21906983
113	S-nitrosylation	GPSIEEDCQKYILKQ CCCHHHHHHHHHHHH	4.20	22178444
113	S-nitrosocysteine	GPSIEEDCQKYILKQ CCCHHHHHHHHHHHH	4.20	-
128	Ubiquitination	QQEEAEKPLQVAAVD HHHHHCCCCCCEECC	21.38	-
132	Ubiquitination	AEKPLQVAAVDSSVP HCCCCCCEECCCCCC	6.71	-
140	Ubiquitination	AVDSSVPRTAELAGI ECCCCCCCCHHHCCC	44.40	-
190	Ubiquitination	EQTNYRLKLCVSDRD HHCCCEEEEEECCCC	30.73	-
203	Ubiquitination	RDVLPGTCVWSIASE CCCCCCHHHHHHHHH	3.51	-
216	S-nitrosylation	SELIEKRCRRMVVVV HHHHHHHHCCCEEEE	4.85	22178444
216	S-nitrosocysteine	SELIEKRCRRMVVVV HHHHHHHHCCCEEEE	4.85	-
227	Ubiquitination	VVVVSDDYLQSKECD EEEECHHHHHCCCCC	16.19	-
230	O-linked_Glycosylation	VSDDYLQSKECDFQT ECHHHHHCCCCCCCE	28.03	30620550
230	Phosphorylation	VSDDYLQSKECDFQT ECHHHHHCCCCCCCE	28.03	29083192
231	Ubiquitination	SDDYLQSKECDFQTK CHHHHHCCCCCCCEE	49.77	-
237	Phosphorylation	SKECDFQTKFALSLS CCCCCCCEEEEEECC	28.29	29083192
242	Phosphorylation	FQTKFALSLSPGAHQ CCEEEEEECCCCCCH	24.30	30108239
244	Ubiquitination	TKFALSLSPGAHQKR EEEEEECCCCCCHHC	20.22	-
244	Phosphorylation	TKFALSLSPGAHQKR EEEEEECCCCCCHHC	20.22	18669862
250	Ubiquitination	LSPGAHQKRLIPIKY CCCCCCHHCCCCCCH	39.03	-
251	Ubiquitination	SPGAHQKRLIPIKYK CCCCCHHCCCCCCHH	31.14	-
257	Phosphorylation	KRLIPIKYKAMKKEF HCCCCCCHHHHHHHC	12.52	22817900
263	Ubiquitination	KYKAMKKEFPSILRF CHHHHHHHCCHHHHH	58.22	-
266	Phosphorylation	AMKKEFPSILRFITV HHHHHCCHHHHHEEE	39.31	29514088
269	Ubiquitination	KEFPSILRFITVCDY HHCCHHHHHEEECCC	21.17	-
270	Phosphorylation	EFPSILRFITVCDYT HCCHHHHHEEECCCC	5.01	-
275	Ubiquitination	LRFITVCDYTNPCTK HHHEEECCCCCCCCH	49.29	-
276	Phosphorylation	RFITVCDYTNPCTKS HHEEECCCCCCCCHH	11.86	23917254
282	Ubiquitination	DYTNPCTKSWFWTRL CCCCCCCHHHHHHHH	53.02	-
291	Ubiquitination	WFWTRLAKALSLP-- HHHHHHHHHHCCC--	55.22	-
295	Ubiquitination	RLAKALSLP------ HHHHHHCCC------	6.41	-
304	Ubiquitination	--------------- ---------------		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	RNF41	Q9H4P4	PMID:19483718

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MYD88_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MYD88_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPOP_HUMAN	SPOP	physical	16189514
TLR2_HUMAN	TLR2	physical	15107846
TLR4_HUMAN	TLR4	physical	15107846
TLR5_HUMAN	TLR5	physical	15107846
TLR9_HUMAN	TLR9	physical	15107846
IRAK1_HUMAN	IRAK1	physical	11976320
RAC1_HUMAN	RAC1	physical	11416133
IRAK1_HUMAN	IRAK1	physical	10383454
IRAK2_HUMAN	IRAK2	physical	10383454
IRAK3_HUMAN	IRAK3	physical	10383454
IRAK1_HUMAN	IRAK1	physical	11960013
IRAK4_HUMAN	IRAK4	physical	11960013
TIRAP_HUMAN	TIRAP	physical	11544529
MYD88_HUMAN	MYD88	physical	11544529
IRAK1_HUMAN	IRAK1	genetic	11544529
IRAK2_HUMAN	IRAK2	genetic	11544529
TRAF6_HUMAN	TRAF6	genetic	11544529
M3K7_HUMAN	MAP3K7	genetic	11544529
IRF7_HUMAN	IRF7	physical	16484229
IRF7_HUMAN	IRF7	physical	15361868
LRRF1_HUMAN	LRRFIP1	physical	19265123
LRRF2_HUMAN	LRRFIP2	physical	19265123
FLII_HUMAN	FLII	physical	19265123
CISH_HUMAN	CISH	physical	16961462
TIRAP_HUMAN	TIRAP	physical	17258210
IRAK4_HUMAN	IRAK4	physical	18221795
TIRAP_HUMAN	TIRAP	physical	20048342
HDAC6_HUMAN	HDAC6	physical	20837465
IRAK1_HUMAN	IRAK1	physical	21903422
TNIP1_HUMAN	TNIP1	physical	22011580
TRAF6_HUMAN	TRAF6	physical	22011580
TRAF3_HUMAN	TRAF3	physical	22011580
IRAK4_HUMAN	IRAK4	physical	22011580
IRAK1_HUMAN	IRAK1	physical	22011580
IRAK2_HUMAN	IRAK2	physical	22011580
IRAK4_HUMAN	IRAK4	physical	12538665
IRAK1_HUMAN	IRAK1	physical	12538665
IRAK1_HUMAN	IRAK1	physical	17920759
MYD88_HUMAN	MYD88	physical	9575168
MYD88_HUMAN	MYD88	physical	17548806
IRAK1_HUMAN	IRAK1	physical	17548806
IRAK4_HUMAN	IRAK4	physical	17548806
BTK_HUMAN	BTK	physical	12724322
IRAK1_HUMAN	IRAK1	physical	16024789
IRF5_HUMAN	IRF5	physical	15665823
IRAK1_HUMAN	IRAK1	physical	16461741
SMAD6_HUMAN	SMAD6	physical	21897371
SMUF1_HUMAN	SMURF1	physical	21897371
BST2_HUMAN	BST2	physical	23221546
TRAF6_HUMAN	TRAF6	physical	23381138
SASH1_HUMAN	SASH1	physical	23776175
KSYK_HUMAN	SYK	physical	23962979
SPOP_HUMAN	SPOP	physical	21988832
SMAD3_HUMAN	SMAD3	physical	21988832
SIAH1_HUMAN	SIAH1	physical	21988832
UBP7_HUMAN	USP7	physical	21988832
THIO_HUMAN	TXN	physical	21988832
TLR7_HUMAN	TLR7	physical	21988832
RPAC1_HUMAN	POLR1C	physical	21988832
MYD88_HUMAN	MYD88	physical	21988832
PRDX1_HUMAN	PRDX1	physical	21988832
PFKAL_HUMAN	PFKL	physical	21988832
SIAH2_HUMAN	SIAH2	physical	21988832
MYD88_HUMAN	MYD88	physical	25416956
IRAK4_HUMAN	IRAK4	physical	25416956
SPOP_HUMAN	SPOP	physical	26186194
MYD88_HUMAN	MYD88	physical	21516116
CYLD_HUMAN	CYLD	physical	26719415
SPOP_HUMAN	SPOP	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
612260	MYD88 deficiency (MYD88D)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MYD88_HUMAN

Related Literatures of Post-Translational Modification