dbPTM

TLR5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TLR5_HUMAN
UniProt AC	O60602
Protein Name	Toll-like receptor 5
Gene Name	TLR5
Organism	Homo sapiens (Human).
Sequence Length	858
Subcellular Localization	Membrane Single-pass type I membrane protein.
Protein Description	Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response..
Protein Sequence	MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTVTKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDFQDVGWFLHKLSQQILKKEKEKKKDNNIPLQTVATIS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	N-linked_Glycosylation	IAFYRFCNLTQVPQV EEEEECCCCCCCCCC	43.33	22173220
46	N-linked_Glycosylation	TQVPQVLNTTERLLL CCCCCCCCHHHHHHH	46.21	22173220
108	Phosphorylation	DLGSSKIYFLHPDAF ECCCCEEEEECCHHH	12.11	-
161	Phosphorylation	KNQIRSLYLHPSFGK HHHHHHHHCCCCCCC	12.29	-
210	Phosphorylation	LAANSLYSRVSVDWG HHHHCHHCCCCCCHH	31.34	24719451
245	N-linked_Glycosylation	WTVDITGNFSNAISK EEEECCCCCCCCCCH	28.64	22173220
342	N-linked_Glycosylation	LDNLQVLNLSYNLLG CCCHHHEEECHHHHH	28.25	22173220
422	N-linked_Glycosylation	LVTLPKINLTANLIH EEEECCCCCCHHEEE	37.15	22173220
526	Phosphorylation	PGVFSHLTALRGLSL CCHHHHHHHHCCCCC	20.44	24719451
595	N-linked_Glycosylation	STFINWLNHTNVTIA HHHHHHHHCCCCEEE	31.39	22173220
598	N-linked_Glycosylation	INWLNHTNVTIAGPP HHHHHCCCCEEECCC	22.76	22173220
680	Acetylation	TAQRLVFKDHPQGTE HCHHHHCCCCCCCCC	47.88	19824857
798	Phosphorylation	VVGSLSQYQLMKHQS HHHCCHHHHHHCCCC	10.55	17157808
805	Phosphorylation	YQLMKHQSIRGFVQK HHHHCCCCHHHHHHH	17.61	16027372
833	Phosphorylation	GWFLHKLSQQILKKE HHHHHHHHHHHHHHH	25.50	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
805	S	Phosphorylation	Kinase	PRKD1	Q15139	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
805	S	Phosphorylation		17442957
Phosphorylated at Ser-805 by PKD/PRKD1; phosphorylation induces the production of inflammatory cytokines.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TLR5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DHRS3_HUMAN	DHRS3	physical	28514442
PTH2_HUMAN	PTRH2	physical	28514442
CNPY3_HUMAN	CNPY3	physical	28514442
SNX14_HUMAN	SNX14	physical	28514442
F213A_HUMAN	FAM213A	physical	28514442
DHRS7_HUMAN	DHRS7	physical	28514442
DDRGK_HUMAN	DDRGK1	physical	28514442
TMX2_HUMAN	TMX2	physical	28514442
CNEP1_HUMAN	CTDNEP1	physical	28514442
MA1A2_HUMAN	MAN1A2	physical	28514442

Drug and Disease Associations

Kegg Disease
H00080	Systemic lupus erythematosus
OMIM Disease
601744	Systemic lupus erythematosus 1 (SLEB1)
Kegg Drug
D10368	Entolimod (USAN)
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TLR5_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Protein kinase D interaction with TLR5 is required for inflammatorysignaling in response to bacterial flagellin."; Ivison S.M., Graham N.R., Bernales C.Q., Kifayet A., Ng N.,Shobab L.A., Steiner T.S.; J. Immunol. 178:5735-5743(2007). Cited for: PHOSPHORYLATION AT SER-805.	17442957 [Abstract]