| UniProt ID | MA1A2_HUMAN | |
|---|---|---|
| UniProt AC | O60476 | |
| Protein Name | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB | |
| Gene Name | MAN1A2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 641 | |
| Subcellular Localization |
Golgi apparatus membrane Single-pass type II membrane protein. |
|
| Protein Description | Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).. | |
| Protein Sequence | MTTPALLPLSGRRIPPLNLGPPSFPHHRATLRLSEKFILLLILSAFITLCFGAFFFLPDSSKHKRFDLGLEDVLIPHVDAGKGAKNPGVFLIHGPDEHRHREEEERLRNKIRADHEKALEEAKEKLRKSREEIRAEIQTEKNKVVQEMKIKENKPLPPVPIPNLVGIRGGDPEDNDIREKREKIKEMMKHAWDNYRTYGWGHNELRPIARKGHSPNIFGSSQMGATIVDALDTLYIMGLHDEFLDGQRWIEDNLDFSVNSEVSVFEVNIRFIGGLLAAYYLSGEEIFKIKAVQLAEKLLPAFNTPTGIPWAMVNLKSGVGRNWGWASAGSSILAEFGTLHMEFIHLSYLTGDLTYYKKVMHIRKLLQKMDRPNGLYPNYLNPRTGRWGQYHTSVGGLGDSFYEYLLKAWLMSDKTDHEARKMYDDAIEAIEKHLIKKSRGGLTFIGEWKNGHLEKKMGHLACFAGGMFALGADGSRADKAGHYLELGAEIARTCHESYDRTALKLGPESFKFDGAVEAVAVRQAEKYYILRPEVIETYWYLWRFTHDPRYRQWGWEAALAIEKYCRVNGGFSGVKDVYSSTPTHDDVQQSFFLAETLKYLYLLFSGDDLLPLDHWVFNTEAHPLPVLHLANTTLSGNPAVR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MTTPALLPL ------CCCCCCCCC | 41.30 | 22223895 | |
| 2 | Phosphorylation | ------MTTPALLPL ------CCCCCCCCC | 41.30 | 22199227 | |
| 3 | Phosphorylation | -----MTTPALLPLS -----CCCCCCCCCC | 12.79 | 22199227 | |
| 10 | Phosphorylation | TPALLPLSGRRIPPL CCCCCCCCCCCCCCC | 28.45 | 22199227 | |
| 297 | Acetylation | KAVQLAEKLLPAFNT HHHHHHHHHHHHHCC | 50.11 | 20167786 | |
| 421 | Ubiquitination | KTDHEARKMYDDAIE CCHHHHHHHHHHHHH | 49.19 | 29967540 | |
| 443 | Phosphorylation | KKSRGGLTFIGEWKN HHCCCCCEEEEEECC | 19.24 | - | |
| 479 | Ubiquitination | ADGSRADKAGHYLEL CCCCCCCHHHCHHHH | 56.11 | - | |
| 564 | Phosphorylation | AALAIEKYCRVNGGF HHHHHHHHHHHCCCC | 3.46 | 24719451 | |
| 580 | O-linked_Glycosylation | GVKDVYSSTPTHDDV CCCCCCCCCCCCCHH | 22.25 | OGP | |
| 581 | O-linked_Glycosylation | VKDVYSSTPTHDDVQ CCCCCCCCCCCCHHH | 26.68 | OGP | |
| 583 | Phosphorylation | DVYSSTPTHDDVQQS CCCCCCCCCCHHHHH | 37.72 | - | |
| 631 | N-linked_Glycosylation | LPVLHLANTTLSGNP CCEEEEECCCCCCCC | 39.70 | UniProtKB CARBOHYD | |
| 633 | O-linked_Glycosylation | VLHLANTTLSGNPAV EEEEECCCCCCCCCC | 20.80 | OGP |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MA1A2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MA1A2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MA1A2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of MA1A2_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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