CNPY3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CNPY3_HUMAN
• UniProt AC: Q9BT09
• Protein Name: Protein canopy homolog 3
• Gene Name: CNPY3
• Organism: Homo sapiens (Human).
• Sequence Length: 278
• Subcellular Localization: Endoplasmic reticulum.
• Protein Description: Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity)..
• Protein Sequence: MDSMPEPASRCLLLLPLLLLLLLLLPAPELGPSQAGAEENDWVRLPSKCEVCKYVAVELKSAFEETGKTKEVIGTGYGILDQKASGVKYTKSDLRLIEVTETICKRLLDYSLHKERTGSNRFAKGMSETFETLHNLVHKGVKVVMDIPYELWNETSAEVADLKKQCDVLVEEFEEVIEDWYRNHQEEDLTEFLCANHVLKGKDTSCLAEQWSGKKGDTAALGGKKSKKKSSRAKAAGGRSSSSKQRKELGGLEGDPSPEEDEGIQKASPLTHSPPDEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MDSMPEPASR -----CCCCCCHHHH	34.63	23322592
47	Phosphorylation	NDWVRLPSKCEVCKY CCCEECCCCCCCCCH	55.30	24719451
48 (in isoform 2)	Ubiquitination	-	32.26	-
85	Phosphorylation	GILDQKASGVKYTKS CHHHHCCCCCCCCHH	51.67	-
90	Phosphorylation	KASGVKYTKSDLRLI CCCCCCCCHHHHHHH	20.53	-
91	Ubiquitination	ASGVKYTKSDLRLIE CCCCCCCHHHHHHHH	38.59	29967540
92	Phosphorylation	SGVKYTKSDLRLIEV CCCCCCHHHHHHHHH	33.79	-
100	Phosphorylation	DLRLIEVTETICKRL HHHHHHHHHHHHHHH	18.02	-
102	Phosphorylation	RLIEVTETICKRLLD HHHHHHHHHHHHHHH	23.47	-
110	Phosphorylation	ICKRLLDYSLHKERT HHHHHHHHHHHHHCC	17.07	-
114	Ubiquitination	LLDYSLHKERTGSNR HHHHHHHHHCCCCCC	54.93	-
117	Phosphorylation	YSLHKERTGSNRFAK HHHHHHCCCCCCCCH	46.16	-
127	Phosphorylation	NRFAKGMSETFETLH CCCCHHHHHHHHHHH	42.00	-
153	N-linked_Glycosylation	DIPYELWNETSAEVA ECCHHHHCCCHHHHH	56.12	12754519
153	N-linked_Glycosylation	DIPYELWNETSAEVA ECCHHHHCCCHHHHH	56.12	12754519
202	Ubiquitination	ANHVLKGKDTSCLAE HHHHHCCCCCCHHHH	57.13	29967540
212	Phosphorylation	SCLAEQWSGKKGDTA CHHHHHHCCCCCCCH	40.19	25159151
214	Acetylation	LAEQWSGKKGDTAAL HHHHHCCCCCCCHHC	48.33	25953088
225	Methylation	TAALGGKKSKKKSSR CHHCCCCCCCCHHHH	71.44	-
225	"N6,N6-dimethyllysine"	TAALGGKKSKKKSSR CHHCCCCCCCCHHHH	71.44	-
226	Phosphorylation	AALGGKKSKKKSSRA HHCCCCCCCCHHHHH	53.87	-
240	Phosphorylation	AKAAGGRSSSSKQRK HHHCCCCCCHHHHHH	37.54	27251275
241	Phosphorylation	KAAGGRSSSSKQRKE HHCCCCCCHHHHHHH	36.95	27251275
242	Phosphorylation	AAGGRSSSSKQRKEL HCCCCCCHHHHHHHH	42.68	27251275
243	Phosphorylation	AGGRSSSSKQRKELG CCCCCCHHHHHHHHC	34.45	18510355
257	Phosphorylation	GGLEGDPSPEEDEGI CCCCCCCCHHHCCCC	50.08	28450419
268	Phosphorylation	DEGIQKASPLTHSPP CCCCCCCCCCCCCCC	27.72	28985074
268	O-linked_Glycosylation	DEGIQKASPLTHSPP CCCCCCCCCCCCCCC	27.72	OGP
271	O-linked_Glycosylation	IQKASPLTHSPPDEL CCCCCCCCCCCCCCC	24.56	55829845
271	Phosphorylation	IQKASPLTHSPPDEL CCCCCCCCCCCCCCC	24.56	28450419
273	Phosphorylation	KASPLTHSPPDEL-- CCCCCCCCCCCCC--	32.66	28450419

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CNPY3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CNPY3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CNPY3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PXDN_HUMAN	PXDN	physical	26186194
LRRC1_HUMAN	LRRC1	physical	26186194
SCRIB_HUMAN	SCRIB	physical	26186194
GT252_HUMAN	COLGALT2	physical	26186194
SELN_HUMAN	SEPN1	physical	26186194
LRC40_HUMAN	LRRC40	physical	26186194
COEA1_HUMAN	COL14A1	physical	26186194
SELT_HUMAN	SELT	physical	26186194
LRC40_HUMAN	LRRC40	physical	28514442
PXDN_HUMAN	PXDN	physical	28514442
LRIG1_HUMAN	LRIG1	physical	28514442
SELT_HUMAN	SELT	physical	28514442
SCRIB_HUMAN	SCRIB	physical	28514442
COEA1_HUMAN	COL14A1	physical	28514442
GT252_HUMAN	COLGALT2	physical	28514442
LRRC1_HUMAN	LRRC1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-153, AND MASSSPECTROMETRY.
PubMed: 19159218