LRRC1_HUMAN - dbPTM
LRRC1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LRRC1_HUMAN
UniProt AC Q9BTT6
Protein Name Leucine-rich repeat-containing protein 1
Gene Name LRRC1
Organism Homo sapiens (Human).
Sequence Length 524
Subcellular Localization Cytoplasm . Membrane
Peripheral membrane protein . Localized at the basolateral side of epithelial cells.
Protein Description
Protein Sequence MFHCIPLWRCNRHVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTALKLKALWLSDNQSQPLLTFQTDTDYTTGEKILTCVLLPQLPSEPTCQENLPRCGALENLVNDVSDEAWNERAVNRVSAIRFVEDEKDEEDNETRTLLRRATPHPGELKHMKKTVENLRNDMNAAKGLDSNKNEVNHAIDRVTTSV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4S-palmitoylation----MFHCIPLWRCN
----CCCCEECCCCC		2.0429575903
16PhosphorylationRCNRHVESIDKRHCS
CCCCCHHHCCCCCCE		34.69-
23PhosphorylationSIDKRHCSLVYVPEE
HCCCCCCEEEECCHH		18.1023312004
32PhosphorylationVYVPEEIYRYARSLE
EECCHHHHHHHHCHH		10.80-
37PhosphorylationEIYRYARSLEELLLD
HHHHHHHCHHHHHCC		31.7719664994
46UbiquitinationEELLLDANQLRELPE
HHHHCCHHHHHHCHH		40.8822817900
60UbiquitinationEQFFQLVKLRKLGLS
HHHHHHHHHHHCCCC		51.6821890473
63UbiquitinationFQLVKLRKLGLSDNE
HHHHHHHHCCCCHHH		58.2922817900
63 (in isoform 2)Ubiquitination-58.2921890473
63 (in isoform 1)Ubiquitination-58.2921890473
63UbiquitinationFQLVKLRKLGLSDNE
HHHHHHHHCCCCHHH		58.2921890473
67PhosphorylationKLRKLGLSDNEIQRL
HHHHCCCCHHHHHHC		36.2727732954
105UbiquitinationPESISFCKALQVADF
CHHHHHHHHHCEECC		50.5521963094
155PhosphorylationGNLYNLASLELRENL
HHHHHHHHHHHHHHH		26.0824719451
195 (in isoform 2)Phosphorylation-12.7927732954
196 (in isoform 2)Phosphorylation-2.3327732954
240PhosphorylationERLPEEISGLTSLTD
HCCCHHHCCCCHHHH		30.91-
243PhosphorylationPEEISGLTSLTDLVI
CHHHCCCCHHHHHHH		25.80-
246PhosphorylationISGLTSLTDLVISQN
HCCCCHHHHHHHCCC		27.3625332170
251PhosphorylationSLTDLVISQNLLETI
HHHHHHHCCCHHHHC		12.9225332170
257PhosphorylationISQNLLETIPDGIGK
HCCCHHHHCCCCCHH		37.4725332170
267UbiquitinationDGIGKLKKLSILKVD
CCCHHHCEEEEEEEC		58.8829967540
269PhosphorylationIGKLKKLSILKVDQN
CHHHCEEEEEEECCC		34.4524719451
272UbiquitinationLKKLSILKVDQNRLT
HCEEEEEEECCCHHH		41.9429967540
306UbiquitinationNQLLTLPKSIGKLKK
CHHHCCCCCHHHHHH		58.7929967540
313UbiquitinationKSIGKLKKLSNLNAD
CCHHHHHHHHCCCCC		68.5329967540
315PhosphorylationIGKLKKLSNLNADRN
HHHHHHHHCCCCCHH		48.4229900121
322UbiquitinationSNLNADRNKLVSLPK
HCCCCCHHHHHCCCH		42.4321890473
323UbiquitinationNLNADRNKLVSLPKE
CCCCCHHHHHCCCHH		51.6829967540
324UbiquitinationLNADRNKLVSLPKEI
CCCCHHHHHCCCHHH		3.4522817900
326PhosphorylationADRNKLVSLPKEIGG
CCHHHHHCCCHHHCC		49.7623312004
378PhosphorylationLHLPLSLTALKLKAL
CCCCCCHHHHHHHHH		26.9427251275
381UbiquitinationPLSLTALKLKALWLS
CCCHHHHHHHHHHCC		45.5421890473
383UbiquitinationSLTALKLKALWLSDN
CHHHHHHHHHHCCCC		39.5922817900
388PhosphorylationKLKALWLSDNQSQPL
HHHHHHCCCCCCCCE		23.96-
392PhosphorylationLWLSDNQSQPLLTFQ
HHCCCCCCCCEEEEE		39.7727251275
397PhosphorylationNQSQPLLTFQTDTDY
CCCCCEEEEECCCCC		22.7527251275
400PhosphorylationQPLLTFQTDTDYTTG
CCEEEEECCCCCCCC		36.3527251275
402PhosphorylationLLTFQTDTDYTTGEK
EEEEECCCCCCCCCC		34.0028348404
406UbiquitinationQTDTDYTTGEKILTC
ECCCCCCCCCCEEEE		36.7922817900
443PhosphorylationENLVNDVSDEAWNER
HHHHHHCCHHHHHHH		32.3726657352
456PhosphorylationERAVNRVSAIRFVED
HHHHHHHHEEEEECC		18.1030266825
465UbiquitinationIRFVEDEKDEEDNET
EEEECCCCCCCCHHH		80.7722817900
465 (in isoform 1)Ubiquitination-80.7721890473
472PhosphorylationKDEEDNETRTLLRRA
CCCCCHHHHHHHHHH		34.9028842319
480PhosphorylationRTLLRRATPHPGELK
HHHHHHHCCCCCHHH		21.9630266825
487UbiquitinationTPHPGELKHMKKTVE
CCCCCHHHHHHHHHH		37.0329967540
492PhosphorylationELKHMKKTVENLRND
HHHHHHHHHHHHHHH		27.7727251275
504UbiquitinationRNDMNAAKGLDSNKN
HHHHHHHHCCCCCHH		58.5629967540
508PhosphorylationNAAKGLDSNKNEVNH
HHHHCCCCCHHHHHH		55.5427251275
523PhosphorylationAIDRVTTSV------
HHHHHHCCC------		19.2325056879
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LRRC1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LRRC1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LRRC1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DPYL1_HUMANCRMP1physical
16169070
CE126_HUMANKIAA1377physical
16169070
DLG4_HUMANDLG4physical
11440998
DLG1_HUMANDLG1physical
11440998
A4_HUMANAPPphysical
21832049
MARE2_HUMANMAPRE2physical
22939629
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LRRC1_HUMAN

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Related Literatures of Post-Translational Modification

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