DHRS7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DHRS7_HUMAN
• UniProt AC: Q9Y394
• Protein Name: Dehydrogenase/reductase SDR family member 7
• Gene Name: DHRS7
• Organism: Homo sapiens (Human).
• Sequence Length: 339
• Protein Sequence: MNWELLLWLLVLCALLLLLVQLLRFLRADGDLTLLWAEWQGRRPEWELTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLDLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGIIVSNICPGPVQSNIVENSLAGEVTKTIGNNGDQSHKMTTSRCVRLMLISMANDLKEVWISEQPFLLVTYLWQYMPTWAWWITNKMGKKRIENFKSGVDADSSYFKIFKTKHD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	Ubiquitination	PEWELTDMVVWVTGA CCEEEEEEEEECCCC	1.89	32015554
53	Ubiquitination	WELTDMVVWVTGASS EEEEEEEEECCCCCC	2.46	29901268
56	Phosphorylation	TDMVVWVTGASSGIG EEEEEECCCCCCCHH	16.00	24043423
59	Phosphorylation	VVWVTGASSGIGEEL EEECCCCCCCHHHHH	30.37	24043423
60	Phosphorylation	VWVTGASSGIGEELA EECCCCCCCHHHHHH	33.62	24043423
68	Phosphorylation	GIGEELAYQLSKLGV CHHHHHHHHHHHHCH	23.70	24043423
71	Phosphorylation	EELAYQLSKLGVSLV HHHHHHHHHHCHHHH	15.43	24043423
73	Ubiquitination	LAYQLSKLGVSLVLS HHHHHHHHCHHHHHH	8.02	23000965
76	Phosphorylation	QLSKLGVSLVLSARR HHHHHCHHHHHHHHH	15.80	24043423
80	Phosphorylation	LGVSLVLSARRVHEL HCHHHHHHHHHHHHH	16.55	24114839
101	Ubiquitination	CLENGNLKEKDILVL HHHCCCCCCCCEEEE	67.71	33845483
103	2-Hydroxyisobutyrylation	ENGNLKEKDILVLPL HCCCCCCCCEEEEEE	48.78	-
103	Ubiquitination	ENGNLKEKDILVLPL HCCCCCCCCEEEEEE	48.78	29901268
123	Ubiquitination	GSHEAATKAVLQEFG CCHHHHHHHHHHHHC	31.60	23000965
123 (in isoform 1)	Ubiquitination	-	31.60	21890473
145	Phosphorylation	NGGMSQRSLCMDTSL CCCCCHHHHHHHCCH	20.48	27499020
163	Phosphorylation	RKLIELNYLGTVSLT HHHHHCCCCCEEEEE	21.09	28464451
166	Phosphorylation	IELNYLGTVSLTKCV HHCCCCCEEEEEEHH	12.34	28464451
168	Phosphorylation	LNYLGTVSLTKCVLP CCCCCEEEEEEHHHH	30.11	28464451
170	Phosphorylation	YLGTVSLTKCVLPHM CCCEEEEEEHHHHHH	18.19	28464451
181	Ubiquitination	LPHMIERKQGKIVTV HHHHHHCCCCCEEEE	51.08	27667366
187	Phosphorylation	RKQGKIVTVNSILGI CCCCCEEEECCCCCH	19.90	18491316
190	Phosphorylation	GKIVTVNSILGIISV CCEEEECCCCCHHCC	18.17	18491316
192	Ubiquitination	IVTVNSILGIISVPL EEEECCCCCHHCCCC	3.96	23000965
195	Ubiquitination	VNSILGIISVPLSIG ECCCCCHHCCCCHHH	3.01	23000965
197	Ubiquitination	SILGIISVPLSIGYC CCCCHHCCCCHHHHH	3.78	23000965
206	Phosphorylation	LSIGYCASKHALRGF CHHHHHHHHHHHHHH	22.78	18491316
241	Ubiquitination	PGPVQSNIVENSLAG CCCCCCCHHHCCCCC	5.07	27667366
252	Ubiquitination	SLAGEVTKTIGNNGD CCCCEEEEECCCCCC	43.23	23000965
255	Ubiquitination	GEVTKTIGNNGDQSH CEEEEECCCCCCHHH	27.12	23000965
257	Ubiquitination	VTKTIGNNGDQSHKM EEEECCCCCCHHHCC	50.64	23000965
263	Ubiquitination	NNGDQSHKMTTSRCV CCCCHHHCCCHHHHH	43.09	-
271	Ubiquitination	MTTSRCVRLMLISMA CCHHHHHHHHHHHHH	20.29	27667366
271 (in isoform 2)	Ubiquitination	-	20.29	21890473
282 (in isoform 2)	Ubiquitination	-	53.75	21890473
282	Ubiquitination	ISMANDLKEVWISEQ HHHHCCHHHHHHCCC	53.75	23000965
285	Ubiquitination	ANDLKEVWISEQPFL HCCHHHHHHCCCCCH	6.89	23000965
287	Ubiquitination	DLKEVWISEQPFLLV CHHHHHHCCCCCHHH	17.92	23000965
321 (in isoform 1)	Ubiquitination	-	58.86	21890473
321	Methylation	KKRIENFKSGVDADS HHHHHHHCCCCCCCC	58.86	-
321	Ubiquitination	KKRIENFKSGVDADS HHHHHHHCCCCCCCC	58.86	27667366
321	Ubiquitination	KKRIENFKSGVDADS HHHHHHHCCCCCCCC	58.86	21890473
322	Phosphorylation	KRIENFKSGVDADSS HHHHHHCCCCCCCCH	39.65	-
328	Phosphorylation	KSGVDADSSYFKIFK CCCCCCCCHHEEEEE	28.76	21949786
329	Phosphorylation	SGVDADSSYFKIFKT CCCCCCCHHEEEEEC	34.83	21815630
330	Phosphorylation	GVDADSSYFKIFKTK CCCCCCHHEEEEECC	16.91	19060867
332	Ubiquitination	DADSSYFKIFKTKHD CCCCHHEEEEECCCC	38.71	21890473
332 (in isoform 1)	Ubiquitination	-	38.71	21890473
332	Ubiquitination	DADSSYFKIFKTKHD CCCCHHEEEEECCCC	38.71	23000965
335	Ubiquitination	SSYFKIFKTKHD--- CHHEEEEECCCC---	61.20	23000965
337	Ubiquitination	YFKIFKTKHD----- HEEEEECCCC-----	46.49	23000965

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DHRS7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DHRS7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DHRS7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ETV5_HUMAN	ETV5	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.