ETV5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ETV5_HUMAN
• UniProt AC: P41161
• Protein Name: ETS translocation variant 5
• Gene Name: ETV5
• Organism: Homo sapiens (Human).
• Sequence Length: 510
• Subcellular Localization: Nucleus.
• Protein Description: Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'..
• Protein Sequence: MDGFYDQQVPFMVPGKSRSEECRGRPVIDRKRKFLDTDLAHDSEELFQDLSQLQEAWLAEAQVPDDEQFVPDFQSDNLVLHAPPPTKIKRELHSPSSELSSCSHEQALGANYGEKCLYNYCAYDRKPPSGFKPLTPPTTPLSPTHQNPLFPPPQATLPTSGHAPAAGPVQGVGPAPAPHSLPEPGPQQQTFAVPRPPHQPLQMPKMMPENQYPSEQRFQRQLSEPCHPFPPQPGVPGDNRPSYHRQMSEPIVPAAPPPPQGFKQEYHDPLYEHGVPGMPGPPAHGFQSPMGIKQEPRDYCVDSEVPNCQSSYMRGGYFSSSHEGFSYEKDPRLYFDDTCVVPERLEGKVKQEPTMYREGPPYQRRGSLQLWQFLVTLLDDPANAHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPDALFSMAFPDNQRPFLKAESECHLSEEDTLPLTHFEDSPAYLLDMDRCSSLPYAEGFAY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MDGFYDQQVPFM ---CCCCCCCCCCCC	20.55	24043423
17	Phosphorylation	PFMVPGKSRSEECRG CCCCCCCCCCHHHCC	47.13	24043423
19	Phosphorylation	MVPGKSRSEECRGRP CCCCCCCCHHHCCCC	44.85	24043423
89	Sumoylation	APPPTKIKRELHSPS CCCCCCCCHHHCCCC	41.18	-
89	Sumoylation	APPPTKIKRELHSPS CCCCCCCCHHHCCCC	41.18	-
94	Phosphorylation	KIKRELHSPSSELSS CCCHHHCCCCHHHHH	38.82	23401153
96	Phosphorylation	KRELHSPSSELSSCS CHHHCCCCHHHHHCC	39.19	25850435
97	Phosphorylation	RELHSPSSELSSCSH HHHCCCCHHHHHCCH	46.04	25850435
100	Phosphorylation	HSPSSELSSCSHEQA CCCCHHHHHCCHHHH	25.83	25850435
101	Phosphorylation	SPSSELSSCSHEQAL CCCHHHHHCCHHHHH	32.06	25850435
103	Phosphorylation	SSELSSCSHEQALGA CHHHHHCCHHHHHCC	31.82	27251275
112	Phosphorylation	EQALGANYGEKCLYN HHHHCCCCCCCCCCH	26.57	27251275
118	Phosphorylation	NYGEKCLYNYCAYDR CCCCCCCCHHHCCCC	17.35	23401153
120	Phosphorylation	GEKCLYNYCAYDRKP CCCCCCHHHCCCCCC	2.49	23401153
123	Phosphorylation	CLYNYCAYDRKPPSG CCCHHHCCCCCCCCC	16.84	23401153
142	Phosphorylation	TPPTTPLSPTHQNPL CCCCCCCCCCCCCCC	29.02	25690035
144	Phosphorylation	PTTPLSPTHQNPLFP CCCCCCCCCCCCCCC	32.49	25690035
223	Phosphorylation	QRFQRQLSEPCHPFP HHHHHHHCCCCCCCC	31.02	29116813
248	Phosphorylation	PSYHRQMSEPIVPAA CCCCCCCCCCCCCCC	31.70	28112733
263	Sumoylation	PPPPQGFKQEYHDPL CCCCCCCCHHCCCCH	49.39	-
263	Sumoylation	PPPPQGFKQEYHDPL CCCCCCCCHHCCCCH	49.39	-
293	Sumoylation	FQSPMGIKQEPRDYC CCCCCCCCCCCCCCC	42.77	-
293	Sumoylation	FQSPMGIKQEPRDYC CCCCCCCCCCCCCCC	42.77	-
299	Phosphorylation	IKQEPRDYCVDSEVP CCCCCCCCCCCCCCC	8.82	24043423
303	Phosphorylation	PRDYCVDSEVPNCQS CCCCCCCCCCCCCCC	21.79	24043423
310	Phosphorylation	SEVPNCQSSYMRGGY CCCCCCCCCHHCCCC	26.15	24043423
311	Phosphorylation	EVPNCQSSYMRGGYF CCCCCCCCHHCCCCC	9.32	24043423
312	Phosphorylation	VPNCQSSYMRGGYFS CCCCCCCHHCCCCCC	8.97	24043423
329	Ubiquitination	HEGFSYEKDPRLYFD CCCCCCCCCCCEEEC	65.87	29967540
350	Sumoylation	ERLEGKVKQEPTMYR HHHCCCCCCCCCCCC	53.05	28112733
350	Sumoylation	ERLEGKVKQEPTMYR HHHCCCCCCCCCCCC	53.05	-
367	Phosphorylation	PPYQRRGSLQLWQFL CCCCCCCHHHHHHHH	15.90	22817900
376	Phosphorylation	QLWQFLVTLLDDPAN HHHHHHHHHHCCHHH	24.61	24043423
390	Phosphorylation	NAHFIAWTGRGMEFK HCCEEEEECCCCEEE	14.15	24043423
419	Phosphorylation	KNRPAMNYDKLSRSL CCCCCCCHHHHHHHH	11.02	26657352
423	Phosphorylation	AMNYDKLSRSLRYYY CCCHHHHHHHHHHHH	26.09	26657352
425	Phosphorylation	NYDKLSRSLRYYYEK CHHHHHHHHHHHHHH	17.52	25954137
443	Phosphorylation	QKVAGERYVYKFVCD HHHCCCCEEEEEEEC	12.11	-
468	Sumoylation	DNQRPFLKAESECHL CCCCCCCHHCCCCCC	50.95	-
468	Sumoylation	DNQRPFLKAESECHL CCCCCCCHHCCCCCC	50.95	-
476	Phosphorylation	AESECHLSEEDTLPL HCCCCCCCCCCCCCC	18.44	30624053
480	Phosphorylation	CHLSEEDTLPLTHFE CCCCCCCCCCCCCCC	33.29	30624053

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
367	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
367	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
367	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
-	K	Ubiquitination	E3 ubiquitin ligase	COP1	Q8NHY2	PMID:20062082

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ETV5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ETV5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RFWD2_HUMAN	RFWD2	physical	20062082
A4_HUMAN	APP	physical	21832049
SE6L2_HUMAN	SEZ6L2	physical	21988832
S22A2_HUMAN	SLC22A2	physical	21988832
HXD9_HUMAN	HOXD9	physical	21988832
STK40_HUMAN	STK40	physical	26186194
MYH14_HUMAN	MYH14	physical	26186194
RFWD2_HUMAN	RFWD2	physical	26186194
UB2E3_HUMAN	UBE2E3	physical	26186194
DET1_HUMAN	DET1	physical	26186194
DET1_HUMAN	DET1	physical	28514442
RFWD2_HUMAN	RFWD2	physical	28514442
STK40_HUMAN	STK40	physical	28514442
UB2E3_HUMAN	UBE2E3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.