SE6L2_HUMAN - dbPTM
SE6L2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SE6L2_HUMAN
UniProt AC Q6UXD5
Protein Name Seizure 6-like protein 2
Gene Name SEZ6L2
Organism Homo sapiens (Human).
Sequence Length 910
Subcellular Localization Cell membrane
Single-pass type I membrane protein . Endoplasmic reticulum membrane
Single-pass type I membrane protein. Detected on cell surface of lung-cancer.
Protein Description May contribute to specialized endoplasmic reticulum functions in neurons..
Protein Sequence MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALLRRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAPELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSPVLCNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPITVESDFSNPLYEAGDTREYEVSI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
43O-linked_GlycosylationLPEPGSETPTVASEA
CCCCCCCCCCHHHHH		26.42OGP
45O-linked_GlycosylationEPGSETPTVASEALA
CCCCCCCCHHHHHHH		35.80OGP
48O-linked_GlycosylationSETPTVASEALAELL
CCCCCHHHHHHHHHH		21.04OGP
80O-linked_GlycosylationDRDPTLATPPAGQTL
CCCCCCCCCCCCCEE		32.68OGP
86O-linked_GlycosylationATPPAGQTLAVPSLP
CCCCCCCEEEECCCC		18.77OGP
96O-linked_GlycosylationVPSLPRATEPGTGPL
ECCCCCCCCCCCCCC		43.9555824809
100O-linked_GlycosylationPRATEPGTGPLTTAV
CCCCCCCCCCCCCEE		46.4755824815
104O-linked_GlycosylationEPGTGPLTTAVTPNG
CCCCCCCCCEECCCC		18.8255824821
105O-linked_GlycosylationPGTGPLTTAVTPNGV
CCCCCCCCEECCCCC		27.1555824827
108O-linked_GlycosylationGPLTTAVTPNGVRGA
CCCCCEECCCCCCCC		14.4755824833
176N-linked_GlycosylationSPVLCNNNISEGEGY
CCEECCCCCCCCCCC		25.77UniProtKB CARBOHYD
222N-linked_GlycosylationEIQVQTLNLSQEEEL
EEEEEECCCCCCCEE		40.82UniProtKB CARBOHYD
247N-linked_GlycosylationLAPRLLANSSMLGEG
HHHHHHHCCCCCCCC		34.29UniProtKB CARBOHYD
332N-linked_GlycosylationEETLICLNGTRPSWN
EEEEEEECCCCCCCC		45.43UniProtKB CARBOHYD
355N-linked_GlycosylationSCGGTIHNATLGRIV
HCCCEEEECCCCCEE		30.67UniProtKB CARBOHYD
373N-linked_GlycosylationPGGAVGPNLTCRWVI
CCCCCCCCCEEEEEE		41.89UniProtKB CARBOHYD
473N-linked_GlycosylationAPFLAHGNVTTTDPE
CCHHCCCCEECCCCC		20.35UniProtKB CARBOHYD
517N-linked_GlycosylationDPTEPHWNDTEPACK
CCCCCCCCCCHHHHH		43.20UniProtKB CARBOHYD
636UbiquitinationQGFVLHFKEVPRNDT
CCEEEEEEECCCCCC		47.24-
641N-linked_GlycosylationHFKEVPRNDTCPELP
EEEECCCCCCCCCCC		42.76UniProtKB CARBOHYD
772UbiquitinationALKYEPCLNPGVPEN
EEEECCCCCCCCCCC		14.6921890473
803 (in isoform 2)Ubiquitination-4.6321890473
816 (in isoform 3)Ubiquitination-25.5821890473
873UbiquitinationYYTKLQGKSLFGFSG
EEEEECCCCCEECCC		30.9021890473
874PhosphorylationYTKLQGKSLFGFSGS
EEEECCCCCEECCCC		35.4426356563
879PhosphorylationGKSLFGFSGSHSYSP
CCCCEECCCCCCCCC		39.5026356563
881PhosphorylationSLFGFSGSHSYSPIT
CCEECCCCCCCCCEE		14.2027732954
883PhosphorylationFGFSGSHSYSPITVE
EECCCCCCCCCEEEE		29.0625884760
884PhosphorylationGFSGSHSYSPITVES
ECCCCCCCCCEEEEE		17.0325884760
885PhosphorylationFSGSHSYSPITVESD
CCCCCCCCCEEEEEC		16.9125884760
886 (in isoform 1)Ubiquitination-20.3121890473
886UbiquitinationSGSHSYSPITVESDF
CCCCCCCCEEEEECC		20.3121890473
888PhosphorylationSHSYSPITVESDFSN
CCCCCCEEEEECCCC		22.9327732954
891PhosphorylationYSPITVESDFSNPLY
CCCEEEEECCCCCCE		39.3527732954
894PhosphorylationITVESDFSNPLYEAG
EEEEECCCCCCEECC		42.3927732954
898PhosphorylationSDFSNPLYEAGDTRE
ECCCCCCEECCCCEE		12.6525884760
903PhosphorylationPLYEAGDTREYEVSI
CCEECCCCEEEECCC		25.20-
906PhosphorylationEAGDTREYEVSI---
ECCCCEEEECCC---		20.5225884760
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SE6L2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SE6L2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SE6L2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KITH_HUMANTK1physical
21988832
UNG_HUMANUNGphysical
21988832
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SE6L2_HUMAN

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Related Literatures of Post-Translational Modification

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