| UniProt ID | CISH_HUMAN | |
|---|---|---|
| UniProt AC | Q9NSE2 | |
| Protein Name | Cytokine-inducible SH2-containing protein | |
| Gene Name | CISH | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 258 | |
| Subcellular Localization | ||
| Protein Description | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).. | |
| Protein Sequence | MVLCVQGPRPLLAVERTGQRPLWAPSLELPKPVMQPLPAGAFLEEVAEGTPAQTESEPKVLDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCTADTRSDSPDPAPTPALPMPKEDAPSDPALPAPPPATAVHLKLVQPFVRRSSARSLQHLCRLVINRLVADVDCLPLPRRMADYLRQYPFQL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 16 | Phosphorylation | RPLLAVERTGQRPLW CCEEEEECCCCCCCC | 37.24 | - | |
| 16 (in isoform 3) | Phosphorylation | - | 37.24 | - | |
| 142 | Phosphorylation | DSSFRLDSNCLSRPR CCCEECCCCCCCCCC | 33.75 | - | |
| 173 | Phosphorylation | SCTADTRSDSPDPAP HCCCCCCCCCCCCCC | 44.53 | 27251275 | |
| 175 | Phosphorylation | TADTRSDSPDPAPTP CCCCCCCCCCCCCCC | 32.23 | 27251275 | |
| 192 | Phosphorylation | PMPKEDAPSDPALPA CCCCCCCCCCCCCCC | 52.14 | 27251275 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CISH_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CISH_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CISH_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| IL2RB_HUMAN | IL2RB | physical | 10514520 | |
| IL3RA_HUMAN | IL3RA | physical | 7796808 | |
| EPOR_HUMAN | EPOR | physical | 7796808 | |
| MYD88_HUMAN | MYD88 | physical | 16961462 | |
| CUL5_HUMAN | CUL5 | physical | 16961462 | |
| ELOB_HUMAN | TCEB2 | physical | 16961462 | |
| ELOC_HUMAN | TCEB1 | physical | 16961462 | |
| CCNE1_HUMAN | CCNE1 | physical | 18508766 | |
| CUL5_HUMAN | CUL5 | physical | 18508766 | |
| CCNC_HUMAN | CCNC | physical | 18508766 | |
| B2L11_HUMAN | BCL2L11 | physical | 18420585 | |
| RACK1_HUMAN | GNB2L1 | physical | 18420585 | |
| ETV5_HUMAN | ETV5 | physical | 21988832 | |
| HSP76_HUMAN | HSPA6 | physical | 21988832 | |
| TB10B_HUMAN | TBC1D10B | physical | 26186194 | |
| CUL5_HUMAN | CUL5 | physical | 26186194 | |
| AMRA1_HUMAN | AMBRA1 | physical | 26186194 | |
| UBC_HUMAN | UBC | physical | 25448846 | |
| GHR_HUMAN | GHR | physical | 25505247 | |
| CUL5_HUMAN | CUL5 | physical | 28514442 | |
| AMRA1_HUMAN | AMBRA1 | physical | 28514442 | |
| TAT_HV1H2 | tat | physical | 27596538 | |
| IL7RA_HUMAN | IL7R | physical | 27596538 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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