| UniProt ID | EPOR_HUMAN | |
|---|---|---|
| UniProt AC | P19235 | |
| Protein Name | Erythropoietin receptor | |
| Gene Name | EPOR | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 508 | |
| Subcellular Localization |
Cell membrane Single-pass type I membrane protein. Isoform EPOR-S: Secreted . Secreted and located to the cell surface. |
|
| Protein Description | Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.; Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling.. | |
| Protein Sequence | MDHLGASLWPQVGSLCLLLAGAAWAPPPNLPDPKFESKAALLAARGPEELLCFTERLEDLVCFWEEAASAGVGPGNYSFSYQLEDEPWKLCRLHQAPTARGAVRFWCSLPTADTSSFVPLELRVTAASGAPRYHRVIHINEVVLLDAPVGLVARLADESGHVVLRWLPPPETPMTSHIRYEVDVSAGNGAGSVQRVEILEGRTECVLSNLRGRTRYTFAVRARMAEPSFGGFWSAWSEPVSLLTPSDLDPLILTLSLILVVILVLLTVLALLSHRRALKQKIWPGIPSPESEFEGLFTTHKGNFQLWLYQNDGCLWWSPCTPFTEDPPASLEVLSERCWGTMQAVEPGTDDEGPLLEPVGSEHAQDTYLVLDKWLLPRNPPSEDLPGPGGSVDIVAMDEGSEASSCSSALASKPSPEGASAASFEYTILDPSSQLLRPWTLCPELPPTPPHLKYLYLVVSDSGISTDYSSGDSQGAQGGLSDGPYSNPYENSLIPAAEPLPPSYVACS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 76 | N-linked_Glycosylation | SAGVGPGNYSFSYQL HCCCCCCCCEEEEEC | 32.20 | UniProtKB CARBOHYD | |
| 108 | Phosphorylation | GAVRFWCSLPTADTS CCEEEEEECCCCCCC | 28.16 | - | |
| 115 | Phosphorylation | SLPTADTSSFVPLEL ECCCCCCCCCCCEEE | 23.48 | - | |
| 116 | Phosphorylation | LPTADTSSFVPLELR CCCCCCCCCCCEEEE | 32.15 | - | |
| 128 | Phosphorylation | ELRVTAASGAPRYHR EEEEEECCCCCCEEE | 32.78 | 23025827 | |
| 185 | Phosphorylation | IRYEVDVSAGNGAGS EEEEEECCCCCCCCC | 26.45 | - | |
| 192 | Phosphorylation | SAGNGAGSVQRVEIL CCCCCCCCEEEEEEE | 17.97 | - | |
| 206 (in isoform 2) | Phosphorylation | - | 5.52 | 23663014 | |
| 207 (in isoform 2) | Phosphorylation | - | 4.20 | 23663014 | |
| 208 (in isoform 2) | Phosphorylation | - | 17.27 | 23663014 | |
| 208 | Phosphorylation | GRTECVLSNLRGRTR CCCEEEHHCCCCCCE | 17.27 | 24719451 | |
| 309 | Phosphorylation | GNFQLWLYQNDGCLW CEEEEEEEECCCCEE | 8.16 | 22817900 | |
| 368 | Phosphorylation | SEHAQDTYLVLDKWL CCCCCCCEEEEEEEC | 11.78 | 12441334 | |
| 407 | Phosphorylation | GSEASSCSSALASKP CCCCCCCCHHHCCCC | 22.16 | 22798277 | |
| 426 | Phosphorylation | ASAASFEYTILDPSS CCCCEEEEEEECCHH | 9.32 | 12441334 | |
| 454 | Phosphorylation | PTPPHLKYLYLVVSD CCCCCCCEEEEEEEC | 13.62 | 12441334 | |
| 456 | Phosphorylation | PPHLKYLYLVVSDSG CCCCCEEEEEEECCC | 8.38 | 12441334 | |
| 468 | Phosphorylation | DSGISTDYSSGDSQG CCCCCCCCCCCCCCC | 12.57 | 12441334 | |
| 485 | Phosphorylation | GGLSDGPYSNPYENS CCCCCCCCCCCCCCC | 26.98 | 12441334 | |
| 489 | Phosphorylation | DGPYSNPYENSLIPA CCCCCCCCCCCCCCC | 31.80 | 12441334 | |
| 504 | Phosphorylation | AEPLPPSYVACS--- CCCCCCCCEECC--- | 9.61 | 12441334 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 368 | Y | Phosphorylation | Kinase | JAK2 | O60674 | Uniprot |
| 368 | Y | Phosphorylation | Kinase | LYN | P07948 | PhosphoELM |
| 426 | Y | Phosphorylation | Kinase | JAK2 | O60674 | Uniprot |
| 454 | Y | Phosphorylation | Kinase | JAK2 | O60674 | Uniprot |
| 456 | Y | Phosphorylation | Kinase | JAK2 | O60674 | Uniprot |
| 468 | Y | Phosphorylation | Kinase | JAK2 | O60674 | Uniprot |
| 485 | Y | Phosphorylation | Kinase | JAK2 | O60674 | Uniprot |
| 489 | Y | Phosphorylation | Kinase | JAK2 | O60674 | Uniprot |
| 504 | Y | Phosphorylation | Kinase | JAK2 | O60674 | Uniprot |
| - | K | Ubiquitination | E3 ubiquitin ligase | BTRC | Q9Y297 | PMID:24658274 |
| - | K | Ubiquitination | E3 ubiquitin ligase | NOSIP | Q9Y314 | PMID:12746455 |
| Modified Location | Modified Residue | Modification | Function | Reference |
|---|---|---|---|---|
| 281 | K | ubiquitylation |
| - |
| 453 | K | ubiquitylation |
| - |
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of EPOR_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| H00236 | Congenital polycythemia; Familial erythrocytosis (ECYT) | |||||
| OMIM Disease | ||||||
| 133100 | Erythrocytosis, familial, 1 (ECYT1) | |||||
| Kegg Drug | ||||||
| D03231 | Epoetin alfa (genetical recombination) (JP16); Epoetin alfa (USAN/INN); Epogen (TN) | |||||
| D03232 | Epoetin beta (genetical recombination) (JP16); Epoetin beta (USAN/INN); Marogen (TN) | |||||
| D03651 | Darbepoetin alfa (genetical recombination) (JAN); Darbepoetin alfa (USAN/INN); Aranesp (TN) | |||||
| D04032 | Epoetin delta (USAN); Dynepo (TN) | |||||
| D09737 | Epoetin kappa (genetical recombination) (Epoetin alfa biosimilar 1) (JAN); Epoetin kappa (INN); Epoe | |||||
| D09946 | Peginesatide (USAN/INN) | |||||
| D09947 | Peginesatide acetate (JAN/USAN); Omontys (TN) | |||||
| D09998 | Epoetin beta pegol (genetical recombination) (JAN); Continuous erythropoietin receptor activator; Mi | |||||
| D10000 | Epoetin epsilon (genetical recombination) (JAN); Epoetin epsilon (INN) | |||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
