SOCS3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SOCS3_HUMAN
• UniProt AC: O14543
• Protein Name: Suppressor of cytokine signaling 3
• Gene Name: SOCS3
• Organism: Homo sapiens (Human).
• Sequence Length: 225
• Protein Description: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity)..
• Protein Sequence: MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPPPGAPSFPSPPTEPSSEVPEQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSRPLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Ubiquitination	--MVTHSKFPAAGMS --CCCCCCCCCCCCC	48.00	12459551
13	O-linked_Glycosylation	KFPAAGMSRPLDTSL CCCCCCCCCCCCCCE	29.81	30379171
23	Ubiquitination	LDTSLRLKTFSSKSE CCCCEEEEECCCCCH	40.88	-
28	Ubiquitination	RLKTFSSKSEYQLVV EEEECCCCCHHHHHH	46.22	-
86	Phosphorylation	FFTLSVKTQSGTKNL EEEEEEEECCCCEEE	26.30	-
101	Phosphorylation	RIQCEGGSFSLQSDP EEEEECCCEEECCCC	23.63	22210691
165	Phosphorylation	GSPPRRAYYIYSGGE CCCCCEEEEEEECCE	6.65	-
166	Phosphorylation	SPPRRAYYIYSGGEK CCCCEEEEEEECCEE	7.75	-
179	Phosphorylation	EKIPLVLSRPLSSNV EEEEEEEECCCCCCH	25.11	24719451
195	Ubiquitination	TLQHLCRKTVNGHLD HHHHHHHHHHCCCCC	56.69	-
204	Phosphorylation	VNGHLDSYEKVTQLP HCCCCCHHHHHHCCC	21.31	16352613
206	Ubiquitination	GHLDSYEKVTQLPGP CCCCHHHHHHCCCCC	42.20	-
221	Phosphorylation	IREFLDQYDAPL--- HHHHHHHCCCCC---	17.46	16352613

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
204	Y	Phosphorylation	Kinase	JAK2	O60674	PSP
204	Y	Phosphorylation	Kinase	LCK	P06239	PSP
221	Y	Phosphorylation	Kinase	JAK2	O60674	PSP
221	Y	Phosphorylation	Kinase	LCK	P06239	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	SOCS2	O14508	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SOCS3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SOCS3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PIN1_HUMAN	PIN1	physical	16169070
PRLR_HUMAN	PRLR	physical	11713228
CXCR4_HUMAN	CXCR4	physical	12163560
LEPR_HUMAN	LEPR	physical	11018044
JAK2_HUMAN	JAK2	physical	10882725
EPOR_HUMAN	EPOR	physical	10882725
JAK2_HUMAN	JAK2	physical	10421843
CSF1R_HUMAN	CSF1R	physical	12133942
RASA1_HUMAN	RASA1	physical	11331873
JAK2_HUMAN	JAK2	physical	9344848
FAK2_HUMAN	PTK2B	physical	9344848
IGF1R_HUMAN	IGF1R	physical	11071852
NONO_HUMAN	NONO	physical	18952062
M3K7_HUMAN	MAP3K7	physical	16543409
TRAF6_HUMAN	TRAF6	physical	16543409
ACADV_HUMAN	ACADVL	physical	22093833
FAK1_HUMAN	PTK2	physical	18031698
VHL_HUMAN	VHL	physical	21685897
DAB1_HUMAN	DAB1	physical	17974915
CUL5_HUMAN	CUL5	physical	17135358
ELOB_HUMAN	TCEB2	physical	17135358
ELOC_HUMAN	TCEB1	physical	17135358
ETV6_HUMAN	ETV6	physical	11314018
JAK2_HUMAN	JAK2	physical	11314018
JAK2_HUMAN	JAK2	physical	19543316
JIP1_HUMAN	MAPK8IP1	physical	18055217
CUED2_HUMAN	CUEDC2	physical	22084247
MAP1S_HUMAN	MAP1S	physical	19027008
SOCS2_HUMAN	SOCS2	physical	16199887
FAK2_HUMAN	PTK2B	physical	18507841
SIGL7_HUMAN	SIGLEC7	physical	17138568
PTN11_HUMAN	PTPN11	physical	17138568
ELOC_HUMAN	TCEB1	physical	12783885
FGFR3_HUMAN	FGFR3	physical	16410555
NFKB1_HUMAN	NFKB1	physical	21451109
TF65_HUMAN	RELA	physical	21451109
REL_HUMAN	REL	physical	21451109
IKBA_HUMAN	NFKBIA	physical	21451109
TNF10_HUMAN	TNFSF10	physical	21308719
JAK2_HUMAN	JAK2	physical	22342841
JAK1_HUMAN	JAK1	physical	10373548
IL2RB_HUMAN	IL2RB	physical	10373548
JAK2_HUMAN	JAK2	physical	15514089
IRS1_HUMAN	IRS1	physical	15514089
IRS2_HUMAN	IRS2	physical	15514089
INSR_HUMAN	INSR	physical	15514089
ELOB_HUMAN	TCEB2	physical	16007195
TFDP1_HUMAN	TFDP1	physical	18687693
A4_HUMAN	APP	physical	21832049
CUL5_HUMAN	CUL5	physical	15601820
RBX2_HUMAN	RNF7	physical	15601820
ELOB_HUMAN	TCEB2	physical	15601820
ELOC_HUMAN	TCEB1	physical	15601820
CUL5_MOUSE	Cul5	physical	15601820
RBX2_MOUSE	Rnf7	physical	15601820
ELOB_MOUSE	Tceb2	physical	15601820
ELOC_MOUSE	Tceb1	physical	15601820
ABL1_HUMAN	ABL1	physical	22787435
TFR2_HUMAN	TFR2	physical	21988832
TES_HUMAN	TES	physical	21988832
TXD11_HUMAN	TXNDC11	physical	21988832
K1958_HUMAN	KIAA1958	physical	25416956
PTK6_HUMAN	PTK6	physical	22547065
TBK1_HUMAN	TBK1	physical	25939384
SH22A_HUMAN	SH2D2A	physical	25814554
TRDN_HUMAN	TRDN	physical	25814554
1433T_HUMAN	YWHAQ	physical	25814554
JAK2_HUMAN	JAK2	physical	24438103
IL6RB_HUMAN	IL6ST	physical	24438103
AMRA1_HUMAN	AMBRA1	physical	28514442
RGP1_HUMAN	RGP1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.