ELOB_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ELOB_MOUSE
• UniProt AC: P62869
• Protein Name: Elongin-B
• Gene Name: Elob {ECO:0000312|MGI:MGI:1914923}
• Organism: Mus musculus (Mouse).
• Sequence Length: 118
• Subcellular Localization: Nucleus .
• Protein Description: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells. [PubMed: 27863225]
• Protein Sequence: MDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPEEQRLYKDDQLLDDGKTLGECGFTSQTARPQAPATVGLAFRADDTFEALRIEPFSSPPELPDVMKPQDSGGSANEQAVQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDVFLMIR -------CCEEEEEE	10.01	-
19	Ubiquitination	TTIFTDAKESSTVFE EEEECCCCCCCCHHH	62.02	-
28	Succinylation	SSTVFELKRIVEGIL CCCHHHHHHHHHHHH	32.64	23954790
36	Ubiquitination	RIVEGILKRPPEEQR HHHHHHHCCCHHHHH	62.02	-
46	Acetylation	PEEQRLYKDDQLLDD HHHHHCCCCCCCCCC	60.46	23806337
46	Succinylation	PEEQRLYKDDQLLDD HHHHHCCCCCCCCCC	60.46	23954790
60	S-nitrosocysteine	DGKTLGECGFTSQTA CCCCCCCCCCCCCCC	5.29	-
60	S-nitrosylation	DGKTLGECGFTSQTA CCCCCCCCCCCCCCC	5.29	21278135
84	Phosphorylation	LAFRADDTFEALRIE EEEECCCCCHHEEEC	24.75	25521595
95	Phosphorylation	LRIEPFSSPPELPDV EEECCCCCCCCCCCC	44.87	25195567
104	Ubiquitination	PELPDVMKPQDSGGS CCCCCCCCCCCCCCC	39.10	-
108	Phosphorylation	DVMKPQDSGGSANEQ CCCCCCCCCCCCHHH	39.54	26643407
111	Phosphorylation	KPQDSGGSANEQAVQ CCCCCCCCCHHHHCC	31.29	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ELOB_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ELOB_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ELOB_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ELOB_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.