TNF10_HUMAN - dbPTM
TNF10_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TNF10_HUMAN
UniProt AC P50591
Protein Name Tumor necrosis factor ligand superfamily member 10
Gene Name TNFSF10
Organism Homo sapiens (Human).
Sequence Length 281
Subcellular Localization Cell membrane
Single-pass type II membrane protein . Secreted . Exists both as membrane-bound and soluble form.
Protein Description Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. [PubMed: 26457518]
Protein Sequence MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKEDDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
95PhosphorylationVRKMILRTSEETIST
HHHHHHHCCHHHHHH		36.7228857561
96PhosphorylationRKMILRTSEETISTV
HHHHHHCCHHHHHHH		27.3126657352
101PhosphorylationRTSEETISTVQEKQQ
HCCHHHHHHHHHHHH		29.9127251275
102PhosphorylationTSEETISTVQEKQQN
CCHHHHHHHHHHHHC		23.5127251275
106UbiquitinationTISTVQEKQQNISPL
HHHHHHHHHHCCCHH		39.84-
133PhosphorylationITGTRGRSNTLSSPN
EECCCCCCCCCCCCC		36.67-
135PhosphorylationGTRGRSNTLSSPNSK
CCCCCCCCCCCCCCC		29.3025003641
137PhosphorylationRGRSNTLSSPNSKNE
CCCCCCCCCCCCCCH		41.5325003641
200PhosphorylationQEEIKENTKNDKQMV
HHHHHHCCCCHHHHH		32.1129978859
213PhosphorylationMVQYIYKYTSYPDPI
HHHHHHHHCCCCCCE		5.5019835603
214PhosphorylationVQYIYKYTSYPDPIL
HHHHHHHCCCCCCEE		20.0319835603
225PhosphorylationDPILLMKSARNSCWS
CCEEEEHHHHHCCCC		20.63-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TNF10_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TNF10_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TNF10_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PPA5_HUMANACP5physical
16169070
RBM48_HUMANRBM48physical
16169070
TNF10_HUMANTNFSF10physical
10651627
TR10D_HUMANTNFRSF10Dphysical
9430226
TR10B_HUMANTNFRSF10Bphysical
11094155
TR10B_HUMANTNFRSF10Bphysical
9311998
TR10B_HUMANTNFRSF10Bphysical
10549288
CFLAR_HUMANCFLARphysical
22266862
CASP8_HUMANCASP8physical
22266862
FADD_HUMANFADDphysical
22266862
TR10B_HUMANTNFRSF10Bphysical
22585859
RIPK1_HUMANRIPK1physical
22585859
TNAP3_HUMANTNFAIP3physical
22585859
TRAF2_HUMANTRAF2physical
22585859
FADD_HUMANFADDphysical
22585859
CASP8_HUMANCASP8physical
22585859
CASP8_HUMANCASP8physical
21822306
FADD_HUMANFADDphysical
21822306
CFLAR_HUMANCFLARphysical
21822306
TR10B_HUMANTNFRSF10Bphysical
21822306
CASP3_HUMANCASP3physical
23703388
CASP8_HUMANCASP8physical
24287696
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D09395 Dulanermin (USAN/INN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TNF10_HUMAN

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Related Literatures of Post-Translational Modification

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