TR10D_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TR10D_HUMAN
• UniProt AC: Q9UBN6
• Protein Name: Tumor necrosis factor receptor superfamily member 10D
• Gene Name: TNFRSF10D
• Organism: Homo sapiens (Human).
• Sequence Length: 386
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway..
• Protein Sequence: MGLWGQSVPTASSARAGRYPGARTASGTRPWLLDPKILKFVVFIVAVLLPVRVDSATIPRQDEVPQQTVAPQQQRRSLKEEECPAGSHRSEYTGACNPCTEGVDYTIASNNLPSCLLCTVCKSGQTNKSSCTTTRDTVCQCEKGSFQDKNSPEMCRTCRTGCPRGMVKVSNCTPRSDIKCKNESAASSTGKTPAAEETVTTILGMLASPYHYLIIIVVLVIILAVVVVGFSCRKKFISYLKGICSGGGGGPERVHRVLFRRRSCPSRVPGAEDNARNETLSNRYLQPTQVSEQEIQGQELAELTGVTVESPEEPQRLLEQAEAEGCQRRRLLVPVNDADSADISTLLDASATLEEGHAKETIQDQLVGSEKLFYEEDEAGSATSCL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MGLWGQSVPTASSA -CCCCCCCCCCHHHH	26.57	26270265
10	Phosphorylation	LWGQSVPTASSARAG CCCCCCCCHHHHCCC	36.70	26270265
55	Phosphorylation	LLPVRVDSATIPRQD HCCCCCCCCCCCCCC	25.18	28188228
57	Phosphorylation	PVRVDSATIPRQDEV CCCCCCCCCCCCCCC	35.15	24114839
127	N-linked_Glycosylation	VCKSGQTNKSSCTTT EECCCCCCCCCCCCC	34.03	UniProtKB CARBOHYD
134	Phosphorylation	NKSSCTTTRDTVCQC CCCCCCCCCCCEEEE	14.37	-
182	N-linked_Glycosylation	RSDIKCKNESAASST HHHCCCCCHHHCCCC	58.90	UniProtKB CARBOHYD
238	Phosphorylation	SCRKKFISYLKGICS HHHHHHHHHHHHHHC	27.78	19664995
239	Phosphorylation	CRKKFISYLKGICSG HHHHHHHHHHHHHCC	13.97	19664995
241	Sumoylation	KKFISYLKGICSGGG HHHHHHHHHHHCCCC	37.69	-
241	Ubiquitination	KKFISYLKGICSGGG HHHHHHHHHHHCCCC	37.69	22053931
245	Phosphorylation	SYLKGICSGGGGGPE HHHHHHHCCCCCCHH	38.25	19664995
263	Phosphorylation	RVLFRRRSCPSRVPG HHHHCCCCCCCCCCC	28.68	28188228
266	Phosphorylation	FRRRSCPSRVPGAED HCCCCCCCCCCCCCH	50.68	23927012
284	Phosphorylation	NETLSNRYLQPTQVS CCCHHCCCCCCCCCC	17.59	22817900
369	Phosphorylation	IQDQLVGSEKLFYEE HHHHHCCCCCCEECC	24.87	21815630
374	Phosphorylation	VGSEKLFYEEDEAGS CCCCCCEECCCCCCC	28.92	24961811
381	Phosphorylation	YEEDEAGSATSCL-- ECCCCCCCCCCCC--	35.11	29514088
383	Phosphorylation	EDEAGSATSCL---- CCCCCCCCCCC----	22.97	29514088
384	Phosphorylation	DEAGSATSCL----- CCCCCCCCCC-----	17.09	29514088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TR10D_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TR10D_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TR10D_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LPPRC_HUMAN	LRPPRC	physical	17353931
MYH10_HUMAN	MYH10	physical	17353931
PUR4_HUMAN	PFAS	physical	17353931
SF3B3_HUMAN	SF3B3	physical	17353931
TIF1B_HUMAN	TRIM28	physical	17353931

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.