CUED2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CUED2_HUMAN
• UniProt AC: Q9H467
• Protein Name: CUE domain-containing protein 2
• Gene Name: CUEDC2
• Organism: Homo sapiens (Human).
• Sequence Length: 287
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism..
• Protein Sequence: MELERIVSAALLAFVQTHLPEADLSGLDEVIFSYVLGVLEDLGPSGPSEENFDMEAFTEMMEAYVPGFAHIPRGTIGDMMQKLSGQLSDARNKENLQPQSSGVQGQVPISPEPLQRPEMLKEETRSSAAAAADTQDEATGAEEELLPGVDVLLEVFPTCSVEQAQWVLAKARGDLEEAVQMLVEGKEEGPAAWEGPNQDLPRRLRGPQKDELKSFILQKYMMVDSAEDQKIHRPMAPKEAPKKLIRYIDNQVVSTKGERFKDVRNPEAEEMKATYINLKPARKYRFH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
82	Ubiquitination	TIGDMMQKLSGQLSD CHHHHHHHHHHHHHC	27.07	21906983
93	Ubiquitination	QLSDARNKENLQPQS HHHCHHHHHCCCCCC	42.29	29967540
100	Phosphorylation	KENLQPQSSGVQGQV HHCCCCCCCCCCCCC	35.42	26074081
101	Phosphorylation	ENLQPQSSGVQGQVP HCCCCCCCCCCCCCC	37.42	28555341
110	Phosphorylation	VQGQVPISPEPLQRP CCCCCCCCCCCCCCH	19.69	25159151
121	Ubiquitination	LQRPEMLKEETRSSA CCCHHHHCHHHHHHH	52.79	21906983
124	Phosphorylation	PEMLKEETRSSAAAA HHHHCHHHHHHHHHH	36.62	23186163
139	Phosphorylation	ADTQDEATGAEEELL HCCCCHHCCHHHHHC	34.57	22210691
158	Phosphorylation	VLLEVFPTCSVEQAQ EEEECCCCCCHHHHH	13.12	22210691
160	Phosphorylation	LEVFPTCSVEQAQWV EECCCCCCHHHHHHH	31.03	22210691
186	Ubiquitination	VQMLVEGKEEGPAAW HHHHHHCCCCCCCCC	38.80	21906983
209	Ubiquitination	RRLRGPQKDELKSFI HHHCCCCHHHHHHHH	57.19	23000965
213	Ubiquitination	GPQKDELKSFILQKY CCCHHHHHHHHHHHH	41.07	23000965
219	Ubiquitination	LKSFILQKYMMVDSA HHHHHHHHHHCCCCH	31.50	23000965
220	Phosphorylation	KSFILQKYMMVDSAE HHHHHHHHHCCCCHH	4.22	27642862
230	Ubiquitination	VDSAEDQKIHRPMAP CCCHHHHCCCCCCCC	53.45	21906983
238	Ubiquitination	IHRPMAPKEAPKKLI CCCCCCCCCCCHHHH	57.90	29967540
254	O-linked_Glycosylation	YIDNQVVSTKGERFK HHHCCEECCCCHHHH	26.08	55821537
255	O-linked_Glycosylation	IDNQVVSTKGERFKD HHCCEECCCCHHHHC	31.30	55821543
256	Acetylation	DNQVVSTKGERFKDV HCCEECCCCHHHHCC	51.79	25953088
256	Sumoylation	DNQVVSTKGERFKDV HCCEECCCCHHHHCC	51.79	-
256	Ubiquitination	DNQVVSTKGERFKDV HCCEECCCCHHHHCC	51.79	27667366
256	Sumoylation	DNQVVSTKGERFKDV HCCEECCCCHHHHCC	51.79	-
261	Ubiquitination	STKGERFKDVRNPEA CCCCHHHHCCCCCCH	62.63	22817900
272	Ubiquitination	NPEAEEMKATYINLK CCCHHHHHHEEECCC	40.64	23000965
274	Phosphorylation	EAEEMKATYINLKPA CHHHHHHEEECCCCC	21.29	25106551
275	Phosphorylation	AEEMKATYINLKPAR HHHHHHEEECCCCCH	7.83	28796482
279	Ubiquitination	KATYINLKPARKYRF HHEEECCCCCHHCCC	31.95	23000965
279	Acetylation	KATYINLKPARKYRF HHEEECCCCCHHCCC	31.95	23236377
283	Ubiquitination	INLKPARKYRFH--- ECCCCCHHCCCC---	42.77	23000965

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
110	S	Phosphorylation	Kinase	CDK1	P06493	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CUED2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CUED2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRGR_HUMAN	PGR	physical	17347654
IKKB_HUMAN	IKBKB	physical	18362886
IKKA_HUMAN	CHUK	physical	18362886
PR15A_HUMAN	PPP1R15A	physical	18362886
PP1A_HUMAN	PPP1CA	physical	18362886
ESR1_HUMAN	ESR1	physical	21572428
CDC27_HUMAN	CDC27	physical	21743465
CDC20_HUMAN	CDC20	physical	21743465
MD2L1_HUMAN	MAD2L1	physical	21743465
SOCS3_HUMAN	SOCS3	physical	22084247
CDC27_HUMAN	CDC27	physical	23776205
FZR1_HUMAN	FZR1	physical	23776205
FZR1_HUMAN	FZR1	physical	26186194
TF2AA_HUMAN	GTF2A1	physical	26186194
TBP_HUMAN	TBP	physical	26186194
HSP74_HUMAN	HSPA4	physical	24685480
FZR1_HUMAN	FZR1	physical	28514442
TBP_HUMAN	TBP	physical	28514442
KHK_HUMAN	KHK	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.