| UniProt ID | KHK_HUMAN | |
|---|---|---|
| UniProt AC | P50053 | |
| Protein Name | Ketohexokinase {ECO:0000312|HGNC:HGNC:6315} | |
| Gene Name | KHK {ECO:0000312|HGNC:HGNC:6315} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 298 | |
| Subcellular Localization | ||
| Protein Description | Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate.. | |
| Protein Sequence | MEEKQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCTVLSLLGAPCAFMGSMAPGHVADFLVADFRRRGVDVSQVAWQSKGDTPSSCCIINNSNGNRTIVLHDTSLPDVSATDFEKVDLTQFKWIHIEGRNASEQVKMLQRIDAHNTRQPPEQKIRVSVEVEKPREELFQLFGYGDVVFVSKDVAKHLGFQSAEEALRGLYGRVRKGAVLVCAWAEEGADALGPDGKLLHSDAFPPPRVVDTLGAGDTFNASVIFSLSQGRSVQEALRFGCQVAGKKCGLQGFDGIV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 25 | Acetylation | SLVDKYPKEDSEIRC HHHHHCCCCCCCCCH | 71.68 | - | |
| 90 (in isoform 2) | Phosphorylation | - | 22.97 | - | |
| 90 | Phosphorylation | VSQVAWQSKGDTPSS HHHHHHHCCCCCCCC | 22.97 | 24275569 | |
| 109 | Phosphorylation | NNSNGNRTIVLHDTS ECCCCCEEEEEEECC | 19.61 | 28857561 | |
| 115 | Phosphorylation | RTIVLHDTSLPDVSA EEEEEEECCCCCCCC | 24.79 | 28857561 | |
| 116 | Phosphorylation | TIVLHDTSLPDVSAT EEEEEECCCCCCCCC | 41.16 | 28857561 | |
| 116 (in isoform 2) | Phosphorylation | - | 41.16 | - | |
| 131 | Phosphorylation | DFEKVDLTQFKWIHI CCCCCCCCEEEEEEE | 27.74 | - | |
| 134 | Ubiquitination | KVDLTQFKWIHIEGR CCCCCEEEEEEECCC | 35.11 | 21890473 | |
| 134 (in isoform 2) | Ubiquitination | - | 35.11 | 21890473 | |
| 134 (in isoform 1) | Ubiquitination | - | 35.11 | 21890473 | |
| 134 | Ubiquitination | KVDLTQFKWIHIEGR CCCCCEEEEEEECCC | 35.11 | 21890473 | |
| 148 | Ubiquitination | RNASEQVKMLQRIDA CCHHHHHHHHHHHCC | 33.32 | - | |
| 197 | Ubiquitination | FVSKDVAKHLGFQSA EEEHHHHHHHCCCCH | 38.93 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KHK_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KHK_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KHK_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| LCN1_HUMAN | LCN1 | physical | 17353931 | |
| LYSC_HUMAN | LYZ | physical | 17353931 | |
| CK5P3_HUMAN | CDK5RAP3 | physical | 17353931 | |
| LHX9_HUMAN | LHX9 | physical | 25416956 | |
| GDE_HUMAN | AGL | physical | 26344197 | |
| PEPL1_HUMAN | NPEPL1 | physical | 26344197 | |
| ST1C4_HUMAN | SULT1C4 | physical | 26344197 | |
| BGAL_HUMAN | GLB1 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 229800 | Fructosuria (FRUCT) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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