ST1C4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ST1C4_HUMAN
• UniProt AC: O75897
• Protein Name: Sulfotransferase 1C4
• Gene Name: SULT1C4
• Organism: Homo sapiens (Human).
• Sequence Length: 302
• Subcellular Localization: Cytoplasm.
• Protein Description: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF)..
• Protein Sequence: MALHDMEDFTFDGTKRLSVNYVKGILQPTDTCDIWDKIWNFQAKPDDLLISTYPKAGTTWTQEIVELIQNEGDVEKSKRAPTHQRFPFLEMKIPSLGSGLEQAHAMPSPRILKTHLPFHLLPPSLLEKNCKIIYVARNPKDNMVSYYHFQRMNKALPAPGTWEEYFETFLAGKVCWGSWHEHVKGWWEAKDKHRILYLFYEDMKKNPKHEIQKLAEFIGKKLDDKVLDKIVHYTSFDVMKQNPMANYSSIPAEIMDHSISPFMRKGAVGDWKKHFTVAQNERFDEDYKKKMTDTRLTFHFQF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	LHDMEDFTFDGTKRL CCCCCCCCCCCCEEE	32.89	28857561
14	Phosphorylation	EDFTFDGTKRLSVNY CCCCCCCCEEEEEEE	18.16	28857561
51	Phosphorylation	KPDDLLISTYPKAGT CCCCEEEECCCCCCC	23.12	29759185
52	Phosphorylation	PDDLLISTYPKAGTT CCCEEEECCCCCCCC	36.53	29759185
53	Phosphorylation	DDLLISTYPKAGTTW CCEEEECCCCCCCCH	8.92	29759185
95	Phosphorylation	FLEMKIPSLGSGLEQ CHHEECCCCCCHHHH	49.16	28857561
98	Phosphorylation	MKIPSLGSGLEQAHA EECCCCCCHHHHHHC	45.56	28857561
108	Phosphorylation	EQAHAMPSPRILKTH HHHHCCCCCHHHHHC	17.46	28857561
124	Phosphorylation	PFHLLPPSLLEKNCK CHHHCCHHHHHCCCE	43.58	24719451
145	Phosphorylation	NPKDNMVSYYHFQRM CCCCCCHHHHHHHHH	14.81	28857561
200	Phosphorylation	HRILYLFYEDMKKNP HHEEEEEHHHHHHCC	14.39	22817900
221	Acetylation	LAEFIGKKLDDKVLD HHHHHCHHCCHHHHH	52.51	30592713
234	Phosphorylation	LDKIVHYTSFDVMKQ HHHHHHHCCHHHHHH	14.19	28857561
235	Phosphorylation	DKIVHYTSFDVMKQN HHHHHHCCHHHHHHC	16.57	28857561
247	Phosphorylation	KQNPMANYSSIPAEI HHCCCCCCCCCCHHH	8.34	24043423
248	Phosphorylation	QNPMANYSSIPAEIM HCCCCCCCCCCHHHH	22.92	24043423
249	Phosphorylation	NPMANYSSIPAEIMD CCCCCCCCCCHHHHC	23.41	24043423
258	Phosphorylation	PAEIMDHSISPFMRK CHHHHCCCCCHHHHC	22.09	28857561
260	Phosphorylation	EIMDHSISPFMRKGA HHHCCCCCHHHHCCC	18.33	24043423

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ST1C4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ST1C4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ST1C4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COPE_HUMAN	COPE	physical	26344197

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.