CDC20_HUMAN - dbPTM
CDC20_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CDC20_HUMAN
UniProt AC Q12834
Protein Name Cell division cycle protein 20 homolog
Gene Name CDC20
Organism Homo sapiens (Human).
Sequence Length 499
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole .
Protein Description Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation..
Protein Sequence MAQFAFESDLHSLLQLDAPIPNAPPARWQRKAKEAAGPAPSPMRAANRSHSAGRTPGRTPGKSSSKVQTTPSKPGGDRYIPHRSAAQMEVASFLLSKENQPENSQTPTKKEHQKAWALNLNGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQGIR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
31UbiquitinationPPARWQRKAKEAAGP
CCHHHHHHHHHHCCC
49.03-
33MethylationARWQRKAKEAAGPAP
HHHHHHHHHHCCCCC
51.42-
41PhosphorylationEAAGPAPSPMRAANR
HHCCCCCCHHHHHHH
33.1719664994
49PhosphorylationPMRAANRSHSAGRTP
HHHHHHHCCCCCCCC
22.9230576142
51PhosphorylationRAANRSHSAGRTPGR
HHHHHCCCCCCCCCC
33.3930576142
55PhosphorylationRSHSAGRTPGRTPGK
HCCCCCCCCCCCCCC
29.2225849741
59PhosphorylationAGRTPGRTPGKSSSK
CCCCCCCCCCCCCCC
42.1625849741
62UbiquitinationTPGRTPGKSSSKVQT
CCCCCCCCCCCCCCC
48.6621906983
63PhosphorylationPGRTPGKSSSKVQTT
CCCCCCCCCCCCCCC
45.8430576142
64PhosphorylationGRTPGKSSSKVQTTP
CCCCCCCCCCCCCCC
37.3518767875
65PhosphorylationRTPGKSSSKVQTTPS
CCCCCCCCCCCCCCC
43.8929449344
66UbiquitinationTPGKSSSKVQTTPSK
CCCCCCCCCCCCCCC
40.0721906983
66AcetylationTPGKSSSKVQTTPSK
CCCCCCCCCCCCCCC
40.0722014574
69PhosphorylationKSSSKVQTTPSKPGG
CCCCCCCCCCCCCCC
43.6030266825
70PhosphorylationSSSKVQTTPSKPGGD
CCCCCCCCCCCCCCC
14.4229255136
72PhosphorylationSKVQTTPSKPGGDRY
CCCCCCCCCCCCCCC
49.7622167270
73UbiquitinationKVQTTPSKPGGDRYI
CCCCCCCCCCCCCCC
49.2221906983
79PhosphorylationSKPGGDRYIPHRSAA
CCCCCCCCCCCCHHH
24.4423312004
84PhosphorylationDRYIPHRSAAQMEVA
CCCCCCCHHHHHHHH
25.5627050516
92PhosphorylationAAQMEVASFLLSKEN
HHHHHHHHHHHCCCC
22.9215525512
96PhosphorylationEVASFLLSKENQPEN
HHHHHHHCCCCCCCC
39.8226074081
97UbiquitinationVASFLLSKENQPENS
HHHHHHCCCCCCCCC
61.7321906983
104PhosphorylationKENQPENSQTPTKKE
CCCCCCCCCCCCHHH
33.5023401153
106PhosphorylationNQPENSQTPTKKEHQ
CCCCCCCCCCHHHHH
32.5222167270
108PhosphorylationPENSQTPTKKEHQKA
CCCCCCCCHHHHHHH
59.1229255136
109SumoylationENSQTPTKKEHQKAW
CCCCCCCHHHHHHHH
58.32-
109UbiquitinationENSQTPTKKEHQKAW
CCCCCCCHHHHHHHH
58.3221906983
109SumoylationENSQTPTKKEHQKAW
CCCCCCCHHHHHHHH
58.32-
110UbiquitinationNSQTPTKKEHQKAWA
CCCCCCHHHHHHHHH
64.0122817900
114UbiquitinationPTKKEHQKAWALNLN
CCHHHHHHHHHHCCC
48.0421906983
129UbiquitinationGFDVEEAKILRLSGK
CCCHHHHHHEEECCC
45.6221906983
134PhosphorylationEAKILRLSGKPQNAP
HHHHEEECCCCCCCC
38.0328985074
136UbiquitinationKILRLSGKPQNAPEG
HHEEECCCCCCCCCH
39.8023000965
144PhosphorylationPQNAPEGYQNRLKVL
CCCCCCHHHHHHHHH
10.8428152594
149UbiquitinationEGYQNRLKVLYSQKA
CHHHHHHHHHHCCCC
27.2722505724
149AcetylationEGYQNRLKVLYSQKA
CHHHHHHHHHHCCCC
27.2725953088
152PhosphorylationQNRLKVLYSQKATPG
HHHHHHHHCCCCCCC
16.4323312004
153PhosphorylationNRLKVLYSQKATPGS
HHHHHHHCCCCCCCC
22.5015525512
155UbiquitinationLKVLYSQKATPGSSR
HHHHHCCCCCCCCCC
48.5721906983
157PhosphorylationVLYSQKATPGSSRKT
HHHCCCCCCCCCCCC
34.9115525512
160PhosphorylationSQKATPGSSRKTCRY
CCCCCCCCCCCCCCC
28.3330576142
161PhosphorylationQKATPGSSRKTCRYI
CCCCCCCCCCCCCCC
43.6515525512
164PhosphorylationTPGSSRKTCRYIPSL
CCCCCCCCCCCCCCC
10.9129083192
167PhosphorylationSSRKTCRYIPSLPDR
CCCCCCCCCCCCCCC
21.2329083192
170PhosphorylationKTCRYIPSLPDRILD
CCCCCCCCCCCCCCC
42.8729083192
174MethylationYIPSLPDRILDAPEI
CCCCCCCCCCCCHHH
29.45-
259UbiquitinationLWDVQQQKRLRNMTS
EECHHHHHHHHHCCC
49.4121906983
266PhosphorylationKRLRNMTSHSARVGS
HHHHHCCCCCCCCCC
12.5030576142
268PhosphorylationLRNMTSHSARVGSLS
HHHCCCCCCCCCCEE
19.9626329039
282PhosphorylationSWNSYILSSGSRSGH
ECCEEEECCCCCCCC
24.0830576142
285PhosphorylationSYILSSGSRSGHIHH
EEEECCCCCCCCCEE
25.81-
304PhosphorylationVAEHHVATLSGHSQE
EEEEEEEEECCCCCE
21.9926552605
306PhosphorylationEHHVATLSGHSQEVC
EEEEEEECCCCCEEC
30.0626552605
309PhosphorylationVATLSGHSQEVCGLR
EEEECCCCCEECCCE
31.4026552605
435UbiquitinationWKYPTMAKVAELKGH
EECCCHHHHHHHCCC
31.0221906983
440UbiquitinationMAKVAELKGHTSRVL
HHHHHHHCCCCEEEE
39.9021906983
448PhosphorylationGHTSRVLSLTMSPDG
CCCEEEEEEEECCCC
20.9522817900
457PhosphorylationTMSPDGATVASAAAD
EECCCCCHHHHHHHH
23.3322817900
466PhosphorylationASAAADETLRLWRCF
HHHHHHHHHHHHHHH
20.0922817900
485UbiquitinationARRREREKASAAKSS
HHHHHHHHHHHHHHH
54.5923000965
487PhosphorylationRREREKASAAKSSLI
HHHHHHHHHHHHHHH
39.5728555341
490SumoylationREKASAAKSSLIHQG
HHHHHHHHHHHHHCC
40.05-
490UbiquitinationREKASAAKSSLIHQG
HHHHHHHHHHHHHCC
40.0523000965
490SumoylationREKASAAKSSLIHQG
HHHHHHHHHHHHHCC
40.05-
490AcetylationREKASAAKSSLIHQG
HHHHHHHHHHHHHCC
40.0525953088
491PhosphorylationEKASAAKSSLIHQGI
HHHHHHHHHHHHCCC
26.1728555341
492PhosphorylationKASAAKSSLIHQGIR
HHHHHHHHHHHCCCC
30.5428555341

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
41SPhosphorylationKinaseBUB1O43683
PSP
72SPhosphorylationKinaseBUB1O43683
PSP
92SPhosphorylationKinaseBUB1O43683
PSP
153SPhosphorylationKinaseBUB1O43683
PSP
157TPhosphorylationKinaseBUB1O43683
PSP
161SPhosphorylationKinaseBUB1O43683
PSP
170SPhosphorylationKinasePLK1P53350
PSP
-KUbiquitinationE3 ubiquitin ligaseFZR1Q9UM11
PMID:23091007
-KUbiquitinationE3 ubiquitin ligaseSPOPO43791
PMID:27780719

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
41SPhosphorylation

15525512
66KAcetylation

22014574
72SPhosphorylation

15525512
92SPhosphorylation

15525512
153SPhosphorylation

15525512
157TPhosphorylation

15525512
161SPhosphorylation

15525512
485Kubiquitylation

21926987
490Kubiquitylation

21926987
490Kubiquitylation

21926987

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference
485Ubiquitination479 (6)RQ;Lrs45461499
  • Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time)
27114598

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KRT85_HUMANKRT85physical
17353931
K1H1_HUMANKRT31physical
17353931
K1H2_HUMANKRT32physical
17353931
TAP26_HUMANCCDC59physical
17353931
SYYM_HUMANYARS2physical
17353931
KR195_HUMANKRTAP19-5physical
17353931
KRA93_HUMANKRTAP9-3physical
17353931
KRA92_HUMANKRTAP9-2physical
17353931
KT33A_HUMANKRT33Aphysical
17353931
HDAC1_HUMANHDAC1physical
15388328
HDAC2_HUMANHDAC2physical
15388328
MD2L1_HUMANMAD2L1physical
11438673
MD2L1_HUMANMAD2L1physical
14607335
MD2L1_HUMANMAD2L1physical
10700282
CDC27_HUMANCDC27physical
14561775
MD2L1_HUMANMAD2L1physical
14561775
SPERI_HUMANSPATC1physical
15280373
BUB1B_HUMANBUB1Bphysical
11907259
BUB1B_HUMANBUB1Bphysical
11030144
AURKA_HUMANAURKAphysical
10377410
BUB1B_HUMANBUB1Bphysical
12196507
CDC27_HUMANCDC27physical
12196507
CDC16_HUMANCDC16physical
12196507
MD2L1_HUMANMAD2L1physical
12196507
CDC27_HUMANCDC27physical
9628895
MD2L1_HUMANMAD2L1physical
9628895
CDC16_HUMANCDC16physical
9628895
CCNA1_HUMANCCNA1physical
10679238
CDC23_HUMANCDC23physical
18997788
CDC16_HUMANCDC16physical
18997788
CDC20_HUMANCDC20physical
18997788
APC10_HUMANANAPC10physical
18997788
APC11_HUMANANAPC11physical
18997788
APC1_HUMANANAPC1physical
18997788
APC7_HUMANANAPC7physical
18997788
BUB1B_HUMANBUB1Bphysical
18997788
MD2L1_HUMANMAD2L1physical
18997788
CDC27_HUMANCDC27physical
18997788
CDN1A_HUMANCDKN1Aphysical
17679094
MD2L1_HUMANMAD2L1physical
17443180
CDC27_HUMANCDC27physical
16479161
CBP_HUMANCREBBPphysical
16319895
EP300_HUMANEP300physical
16319895
ANC2_HUMANANAPC2physical
16287863
FZR1_HUMANFZR1physical
16287863
BUB1B_HUMANBUB1Bphysical
20512932
MD2L1_HUMANMAD2L1physical
20512932
FBXW5_HUMANFBXW5physical
21725316
RASF1_HUMANRASSF1physical
21874044
MD2L1_HUMANMAD2L1physical
21926987
BUB3_HUMANBUB3physical
21926987
HSF1_HUMANHSF1physical
18059335
CDC27_HUMANCDC27physical
18059335
BUB1B_HUMANBUB1Bphysical
19820702
CCNB1_HUMANCCNB1physical
19820702
HSF2_HUMANHSF2physical
20937767
TTK_HUMANTTKphysical
20729194
UBE2S_HUMANUBE2Sphysical
19822757
CDR2_HUMANCDR2physical
20383333
CCNB1_HUMANCCNB1physical
20383333
CCNA2_HUMANCCNA2physical
20733051
BUB1B_HUMANBUB1Bphysical
20733051
APC4_HUMANANAPC4physical
21926987
BUB1B_HUMANBUB1Bphysical
21926987
ANC2_HUMANANAPC2physical
21937719
BUB1B_HUMANBUB1Bphysical
21937719
MXI1_HUMANMXI1physical
21937719
CUED2_HUMANCUEDC2physical
21743465
MD2L1_HUMANMAD2L1physical
21743465
ID1_HUMANID1physical
18372912
NINL_HUMANNINLphysical
17403670
FZR1_HUMANFZR1physical
17403670
PTTG1_HUMANPTTG1physical
17360335
CCNB1_HUMANCCNB1physical
17360335
BUB1B_HUMANBUB1Bphysical
17360335
MD2L1_HUMANMAD2L1physical
17360335
CDC27_HUMANCDC27physical
17360335
CCNB1_HUMANCCNB1physical
20733055
PTTG1_HUMANPTTG1physical
16455800
CLSPN_HUMANCLSPNphysical
19477924
CCNA1_HUMANCCNA1physical
19477924
BUB1B_HUMANBUB1Bphysical
18591651
MD2L1_HUMANMAD2L1physical
20081372
MD2L1_HUMANMAD2L1physical
21335556
CDC27_HUMANCDC27physical
21335556
SKP2_HUMANSKP2physical
15014502
CKS1_HUMANCKS1Bphysical
15014502
MDC1_HUMANMDC1physical
19826003
MD2L1_HUMANMAD2L1physical
19826003
APC7_HUMANANAPC7physical
19826003
FBW1A_HUMANBTRCphysical
18354482
AURKB_HUMANAURKBphysical
15923616
HSF1_HUMANHSF1physical
18794143
MD2L1_HUMANMAD2L1physical
18794143
CDC27_HUMANCDC27physical
18794143
PTTG1_HUMANPTTG1physical
11562349
GEMI_HUMANGMNNphysical
11562349
CCNB1_HUMANCCNB1physical
11562349
BUB1B_HUMANBUB1Bphysical
11702782
MD2L1_HUMANMAD2L1physical
11702782
FBX5_HUMANFBXO5physical
11751633
CDC27_HUMANCDC27physical
18471975
CCNA2_HUMANCCNA2physical
18471975
CCNB1_HUMANCCNB1physical
18471975
MD2L1_HUMANMAD2L1physical
11707408
ANC2_HUMANANAPC2physical
11438673
MD2L1_HUMANMAD2L1physical
19098431
CDC27_HUMANCDC27physical
19098431
BUB1B_HUMANBUB1Bphysical
19098431
CCNA2_HUMANCCNA2physical
19098431
MD2L1_HUMANMAD2L1physical
18022367
RASF1_HUMANRASSF1physical
14743218
BUB1B_HUMANBUB1Bphysical
17598981
MD2L1_HUMANMAD2L1physical
16497171
MD2BP_HUMANMAD2L1BPphysical
22100920
CDC20_HUMANCDC20physical
22100920
MD2L1_HUMANMAD2L1physical
22100920
BUB1B_HUMANBUB1Bphysical
22100920
UBE2C_HUMANUBE2Cphysical
19820702
A4_HUMANAPPphysical
21832049
CDC20_HUMANCDC20physical
23007861
CDC27_HUMANCDC27physical
23239745
PTTG1_HUMANPTTG1physical
23239745
CCNB1_HUMANCCNB1physical
23239745
BUB1B_HUMANBUB1Bphysical
23239745
MD2L1_HUMANMAD2L1physical
23239745
BUB1B_HUMANBUB1Bphysical
23091007
PTTG1_HUMANPTTG1physical
23091007
CCNB1_HUMANCCNB1physical
23091007
CDC27_HUMANCDC27physical
23160376
APC7_HUMANANAPC7physical
23160376
APC5_HUMANANAPC5physical
23160376
TRI33_HUMANTRIM33physical
23160376
NEK2_HUMANNEK2physical
23160376
PLK1_HUMANPLK1physical
23160376
MD2L1_HUMANMAD2L1physical
22340593
P73_HUMANTP73physical
22340593
AURKA_HUMANAURKAphysical
22340593
HDAC6_HUMANHDAC6physical
19167333
TBG1_HUMANTUBG1physical
19167333
BUB1B_HUMANBUB1Bphysical
21407176
MD2L1_HUMANMAD2L1physical
21407176
MD2L1_HUMANMAD2L1physical
16525508
AXIN2_HUMANAXIN2physical
22322943
MD2L1_HUMANMAD2L1physical
23754430
PLK1_HUMANPLK1physical
23643811
MD2L1_HUMANMAD2L1physical
23643811
BUB1B_HUMANBUB1Bphysical
23643811
BUB3_HUMANBUB3physical
23643811
CDC27_HUMANCDC27physical
23643811
CCNB1_HUMANCCNB1physical
23791783
MD2L1_HUMANMAD2L1physical
23791783
PHF8_HUMANPHF8physical
23979597
CDC27_HUMANCDC27physical
23979597
CCNB1_HUMANCCNB1physical
23979597
MD2L1_HUMANMAD2L1physical
24581499
BUB1B_HUMANBUB1Bphysical
24581499
CDC27_HUMANCDC27physical
24811168
STAU1_HUMANSTAU1physical
24906885
TBA1A_HUMANTUBA1Aphysical
23443559
TBB5_HUMANTUBBphysical
23443559
TCPZ_HUMANCCT6Aphysical
23443559
TBB4B_HUMANTUBB4Bphysical
23443559
TCPE_HUMANCCT5physical
23443559
TCPQ_HUMANCCT8physical
23443559
TCPB_HUMANCCT2physical
23443559
TBB2A_HUMANTUBB2Aphysical
23443559
HSP7C_HUMANHSPA8physical
23443559
BUB1B_HUMANBUB1Bphysical
23443559
TCPA_HUMANTCP1physical
23443559
CDC16_HUMANCDC16physical
23443559
ANC2_HUMANANAPC2physical
23443559
CH60_HUMANHSPD1physical
23443559
TCPG_HUMANCCT3physical
23443559
BUB3_HUMANBUB3physical
23443559
TCPD_HUMANCCT4physical
23443559
CDC23_HUMANCDC23physical
23443559
TBA1C_HUMANTUBA1Cphysical
23443559
CDC26_HUMANCDC26physical
23443559
TCPH_HUMANCCT7physical
23443559
GRP78_HUMANHSPA5physical
23443559
RS3_HUMANRPS3physical
23443559
CPVL_HUMANCPVLphysical
23443559
CPNS1_HUMANCAPNS1physical
23443559
APC7_HUMANANAPC7physical
23443559
CDC27_HUMANCDC27physical
23443559
RAVR1_HUMANRAVER1physical
23443559
GRP75_HUMANHSPA9physical
23443559
FGFR1_HUMANFGFR1physical
23443559
MD2L1_HUMANMAD2L1physical
23443559
DSC1_HUMANDSC1physical
23443559
PB1_HUMANPBRM1physical
23443559
HS71L_HUMANHSPA1Lphysical
23443559
RL23_HUMANRPL23physical
23443559
TBA4A_HUMANTUBA4Aphysical
23443559
UBB_HUMANUBBphysical
23443559
HNRPF_HUMANHNRNPFphysical
23443559
APC4_HUMANANAPC4physical
23443559
FRY_HUMANFRYphysical
23443559
APC16_HUMANANAPC16physical
23443559
EIF2A_HUMANEIF2Aphysical
23443559
CILP1_HUMANCILPphysical
23443559
BUB1_HUMANBUB1physical
23443559
PTTG1_HUMANPTTG1physical
24930963
MD2L1_HUMANMAD2L1physical
25092294
CDC27_HUMANCDC27physical
25161877
FBX43_HUMANFBXO43physical
25161877
CCNB1_HUMANCCNB1physical
25246557
CCNB1_HUMANCCNB1physical
25306923
CCNB1_HUMANCCNB1physical
19826003
CCNA2_HUMANCCNA2physical
19826003
CCNB1_HUMANCCNB1physical
23288039
PTTG1_HUMANPTTG1physical
22193957
CCNB1_HUMANCCNB1physical
22193957
CCNB1_HUMANCCNB1physical
20080579
PTTG1_HUMANPTTG1physical
20080579
CCNB1_HUMANCCNB1physical
25161877
E2F1_HUMANE2F1physical
25368385
TFDP1_HUMANTFDP1physical
25368385
PTTG1_HUMANPTTG1physical
25383541
APC1_HUMANANAPC1physical
24464857
CDC27_HUMANCDC27physical
24464857
APC4_HUMANANAPC4physical
24464857
BUB1B_HUMANBUB1Bphysical
24464857
MD2L1_HUMANMAD2L1physical
24464857
BUB3_HUMANBUB3physical
24464857
CDC16_HUMANCDC16physical
24464857
APC7_HUMANANAPC7physical
24464857
CDC23_HUMANCDC23physical
24464857
PTTG1_HUMANPTTG1physical
24781523
CCNA2_HUMANCCNA2physical
19483727
CDC20_HUMANCDC20physical
21937719
CDC27_HUMANCDC27physical
12956947
APC7_HUMANANAPC7physical
12956947
CCNB1_HUMANCCNB1physical
12956947
CCNB1_HUMANCCNB1physical
22014574
CCNB1_HUMANCCNB1physical
23007861
PTTG1_HUMANPTTG1physical
25161877
KI18A_HUMANKIF18Aphysical
23288039
E2F1_HUMANE2F1physical
20948288
MD2L1_HUMANMAD2L1physical
20054826
CDC27_HUMANCDC27physical
20054826
UBR5_HUMANUBR5physical
25833949
BUB1B_HUMANBUB1Bphysical
25833949
BUB3_HUMANBUB3physical
25833949
CCNB1_HUMANCCNB1physical
25505175
CCNA2_HUMANCCNA2physical
25669885
PTTG1_HUMANPTTG1physical
25669885
BUB1B_HUMANBUB1Bphysical
25669885
MD2L1_HUMANMAD2L1physical
25669885
CCNB1_HUMANCCNB1physical
25825779
BUB1B_HUMANBUB1Bphysical
25750436
APC4_HUMANANAPC4physical
25750436
CDC27_HUMANCDC27physical
25750436
CDC20_HUMANCDC20physical
25750436
CCNA2_HUMANCCNA2physical
25750436
FBX5_HUMANFBXO5physical
25750436
MD2L1_HUMANMAD2L1physical
25750436
APC10_HUMANANAPC10physical
25750436
BUB1B_HUMANBUB1Bphysical
25241761
APC11_HUMANANAPC11physical
25241761
APC1_HUMANANAPC1physical
25482201
BUB3_HUMANBUB3physical
25482201
BUB1B_HUMANBUB1Bphysical
25482201
MD2L1_HUMANMAD2L1physical
25482201
MD2BP_HUMANMAD2L1BPphysical
25482201
CCNB1_HUMANCCNB1physical
25482201
PCH2_HUMANTRIP13physical
26324890
CCNB1_HUMANCCNB1physical
24151075
CDC27_HUMANCDC27physical
25673878
NEK2_HUMANNEK2physical
25673878
MD2L1_HUMANMAD2L1physical
25673878
PRKN_HUMANPARK2physical
26387737
CCNB1_HUMANCCNB1physical
26387737
APC11_HUMANANAPC11physical
26387737
ANC2_HUMANANAPC2physical
26387737
PTTG1_HUMANPTTG1physical
26387737
UBE2S_HUMANUBE2Sphysical
25306918
BUB1B_HUMANBUB1Bphysical
25306918
APC5_HUMANANAPC5physical
25306918
APC1_HUMANANAPC1physical
25306918
ANC2_HUMANANAPC2physical
25306918
CDC27_HUMANCDC27physical
25306918
APC4_HUMANANAPC4physical
25306918
APC7_HUMANANAPC7physical
25306918
CDC16_HUMANCDC16physical
25306918
CDC23_HUMANCDC23physical
25306918
APC10_HUMANANAPC10physical
25306918
CDC26_HUMANCDC26physical
25306918
APC16_HUMANANAPC16physical
25306918
MD2BP_HUMANMAD2L1BPphysical
25306918
BUB1_HUMANBUB1physical
25306918
MD1L1_HUMANMAD1L1physical
25306918
BUB3_HUMANBUB3physical
25306918
MD2L1_HUMANMAD2L1physical
25306918
SKP2_HUMANSKP2physical
25306918
CCNA2_HUMANCCNA2physical
25306918
TCPA_HUMANTCP1physical
25306918
TCPB_HUMANCCT2physical
25306918
TCPG_HUMANCCT3physical
25306918
TCPD_HUMANCCT4physical
25306918
TCPE_HUMANCCT5physical
25306918
TCPZ_HUMANCCT6Aphysical
25306918
TCPH_HUMANCCT7physical
25306918
TCPQ_HUMANCCT8physical
25306918
UBC_HUMANUBCphysical
25306918
NEK2_HUMANNEK2physical
25306918
2A5E_HUMANPPP2R5Ephysical
26811472
PP2AA_HUMANPPP2CAphysical
26811472
PP2AB_HUMANPPP2CBphysical
26811472
2AAA_HUMANPPP2R1Aphysical
26811472
BUB1B_HUMANBUB1Bphysical
26811472
MD2L1_HUMANMAD2L1physical
26811472
BUB1_HUMANBUB1physical
26811472
KNL1_HUMANCASC5physical
26811472
BUB3_HUMANBUB3physical
26811472
UBE2S_HUMANUBE2Sphysical
26811472
APC1_HUMANANAPC1physical
26811472
ANC2_HUMANANAPC2physical
26811472
CDC27_HUMANCDC27physical
26811472
APC4_HUMANANAPC4physical
26811472
APC5_HUMANANAPC5physical
26811472
CDC16_HUMANCDC16physical
26811472
APC7_HUMANANAPC7physical
26811472
CDC23_HUMANCDC23physical
26811472
APC10_HUMANANAPC10physical
26811472
CDC26_HUMANCDC26physical
26811472
APC16_HUMANANAPC16physical
26811472
TCPA_HUMANTCP1physical
26811472
TCPB_HUMANCCT2physical
26811472
TCPG_HUMANCCT3physical
26811472
TCPD_HUMANCCT4physical
26811472
TCPE_HUMANCCT5physical
26811472
TCPZ_HUMANCCT6Aphysical
26811472
TCPH_HUMANCCT7physical
26811472
TCPQ_HUMANCCT8physical
26811472
CDK2_HUMANCDK2physical
26811472
SKP2_HUMANSKP2physical
26811472
PCNA_HUMANPCNAphysical
26811472
CCNA2_HUMANCCNA2physical
26811472
2A5A_HUMANPPP2R5Aphysical
26811472
UBC_HUMANUBCphysical
26811472
DCPS_HUMANDCPSphysical
27120157
CDC27_HUMANCDC27physical
24100295
CDC16_HUMANCDC16physical
24100295
UBP22_HUMANUSP22physical
27030811
APC1_HUMANANAPC1physical
27114510
ANC2_HUMANANAPC2physical
27114510
BUB1B_HUMANBUB1Bphysical
27114510
APC4_HUMANANAPC4physical
27114510
APC5_HUMANANAPC5physical
27114510
CDC16_HUMANCDC16physical
27114510
APC7_HUMANANAPC7physical
27114510
CDC23_HUMANCDC23physical
27114510
CDC27_HUMANCDC27physical
27114510
BUB3_HUMANBUB3physical
27114510
PTTG1_HUMANPTTG1physical
27114510
PTTG1_HUMANPTTG1physical
27509861
DCPS_HUMANDCPSphysical
27601667
BUB1B_HUMANBUB1Bphysical
28514442
CCNA2_HUMANCCNA2physical
28514442
MD2BP_HUMANMAD2L1BPphysical
28514442
CKS1_HUMANCKS1Bphysical
28514442
SYYM_HUMANYARS2physical
28514442
EP300_HUMANEP300physical
28514442
APC16_HUMANANAPC16physical
28514442
CDK2_HUMANCDK2physical
28514442
BUB3_HUMANBUB3physical
28514442
TCPG_HUMANCCT3physical
28514442
CKS2_HUMANCKS2physical
28514442
CDK1_HUMANCDK1physical
28514442
TCPH_HUMANCCT7physical
28514442
APC4_HUMANANAPC4physical
23007648
BUB1B_HUMANBUB1Bphysical
23007648
MD2L1_HUMANMAD2L1physical
23007648
CCNA2_HUMANCCNA2physical
23007648
PTTG1_HUMANPTTG1physical
23007648
CDC16_HUMANCDC16physical
23007648
MD2BP_HUMANMAD2L1BPphysical
23007648
CCNB1_HUMANCCNB1physical
26912231
BUB1B_HUMANBUB1Bphysical
26912231
MD2BP_HUMANMAD2L1BPphysical
26912231
MD2L1_HUMANMAD2L1physical
26912231
BUB1_HUMANBUB1physical
26912231
PTTG1_HUMANPTTG1physical
26912231
CDC20_HUMANCDC20physical
26912231
BANP_HUMANBANPphysical
28617439
CDC27_HUMANCDC27physical
26960431
BUB1B_HUMANBUB1Bphysical
26960431
CCNA2_HUMANCCNA2physical
26960431
APC1_HUMANANAPC1physical
26960431
APC7_HUMANANAPC7physical
26960431
TCPE_HUMANCCT5physical
28096334
MD2L1_HUMANMAD2L1physical
28096334
NUP98_HUMANNUP98physical
27097363
HXD13_HUMANHOXD13physical
27097363
LNP1_HUMANLNP1physical
27097363
HHEX_HUMANHHEXphysical
27097363

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CDC20_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41, AND MASSSPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41, AND MASSSPECTROMETRY.
"Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism forAPC/C inhibition by the spindle checkpoint.";
Tang Z., Shu H., Oncel D., Chen S., Yu H.;
Mol. Cell 16:387-397(2004).
Cited for: PHOSPHORYLATION AT SER-41; SER-72; SER-92; SER-153; THR-157 ANDSER-161, MASS SPECTROMETRY, INTERACTION WITH BUB1B AND MAD2L1, ANDMUTAGENESIS OF SER-41; SER-72; SER-92; SER-153; THR-157 AND SER-161.
"Mitotic regulation of the human anaphase-promoting complex byphosphorylation.";
Kraft C., Herzog F., Gieffers C., Mechtler K., Hagting A., Pines J.,Peters J.-M.;
EMBO J. 22:6598-6609(2003).
Cited for: PHOSPHORYLATION AT THR-70 AND THR-106.
Ubiquitylation
ReferencePubMed
"APC15 drives the turnover of MCC-CDC20 to make the spindle assemblycheckpoint responsive to kinetochore attachment.";
Mansfeld J., Collin P., Collins M.O., Choudhary J.S., Pines J.;
Nat. Cell Biol. 13:1234-1243(2011).
Cited for: UBIQUITINATION AT LYS-485 AND LYS-490, AND MUTAGENESIS OF LYS-485 ANDLYS-490.

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