SPERI_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPERI_HUMAN
• UniProt AC: Q76KD6
• Protein Name: Speriolin
• Gene Name: SPATC1
• Organism: Homo sapiens (Human).
• Sequence Length: 591
• Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Colocalizes with the centrosomal pericentrin protein PCNT1 (By similarity). Located in the connecting piece of sperm.
• Protein Sequence: MSLLTNYEGLRHQIERLVRENEELKKLVRLIRENHELKSAIKTQAGGLGISGFTSGLGEATAGLSSRQNNGVFLPPSPAVANERVLEEVGIMALAPLAEMLTSLQPSATPGSLMSPLTGTLSTLLSGPAPTSQSSPLTSFLTSPIAGPLTGTLASSLGLPSTGTLTPSSLVAGPVAMSQSSPLIAPVMGTVAVSLSSPLLSSTATPPGVSQNLLANPMSNLVLPEAPRLRLAEPLRGGPTGPQSPACVVPTATTKVPLSTEPPQSTQDPEPLSMAFAGAPLQTSTPIGAMGTPAPKTAFSFNTSDTQAQPSAAQEQVVPASVPTSPTTSPTVTVLASAPALAPQVATSYTPSSTTHIAQGAPHPPSRMHNSPTQNLPVPHCPPHNAHSPPRTSSSPASVNDSRGPRTTEPSTKSMMEVERKLAHRKTSKFPENPRESKQLAWERLVGEIAFQLDRRILSSIFPERVRLYGFTVSNIPEKIIQASLNPSDHKLDEKLCQRLTQRYVSVMNRLQSLGYNGRVHPALTEQLVNAYGILRERPELAASEGGPYTVDFLQRVVVETVHPGMLADALLLLSCLSQLAHDDGKPMFIW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLLTNYEG ------CCCCCCHHH	31.89	25693802
5	Phosphorylation	---MSLLTNYEGLRH ---CCCCCCHHHHHH	40.84	25693802
7	Phosphorylation	-MSLLTNYEGLRHQI -CCCCCCHHHHHHHH	13.21	25693802
240	Phosphorylation	EPLRGGPTGPQSPAC CCCCCCCCCCCCCCE	65.84	25693802
244	Phosphorylation	GGPTGPQSPACVVPT CCCCCCCCCCEEECC	20.00	25693802
392	Phosphorylation	NAHSPPRTSSSPASV CCCCCCCCCCCCCCC	38.44	30622161
393	Phosphorylation	AHSPPRTSSSPASVN CCCCCCCCCCCCCCC	30.05	30622161
394	Phosphorylation	HSPPRTSSSPASVND CCCCCCCCCCCCCCC	39.46	30622161
395	Phosphorylation	SPPRTSSSPASVNDS CCCCCCCCCCCCCCC	25.01	30622161
402	Phosphorylation	SPASVNDSRGPRTTE CCCCCCCCCCCCCCC	33.65	-
408	Phosphorylation	DSRGPRTTEPSTKSM CCCCCCCCCCCHHHH	47.37	29759185
414	Phosphorylation	TTEPSTKSMMEVERK CCCCCHHHHHHHHHH	24.37	30622161
427	Phosphorylation	RKLAHRKTSKFPENP HHHHHHCCCCCCCCH	36.79	30622161
428	Phosphorylation	KLAHRKTSKFPENPR HHHHHCCCCCCCCHH	35.02	30622161
459	Phosphorylation	QLDRRILSSIFPERV HHHHHHHHHHCHHHH	21.01	24114839
460	Phosphorylation	LDRRILSSIFPERVR HHHHHHHHHCHHHHH	25.46	24114839
484	Phosphorylation	PEKIIQASLNPSDHK CHHHHHHHCCCCCCC	16.59	30622161
488	Phosphorylation	IQASLNPSDHKLDEK HHHHCCCCCCCCCHH	51.80	30622161
501	Phosphorylation	EKLCQRLTQRYVSVM HHHHHHHHHHHHHHH	17.12	29759185
504	Phosphorylation	CQRLTQRYVSVMNRL HHHHHHHHHHHHHHH	6.30	29759185
506	Phosphorylation	RLTQRYVSVMNRLQS HHHHHHHHHHHHHHH	13.50	28152594

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPERI_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPERI_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPERI_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDC20_HUMAN	CDC20	physical	15280373
CDC27_HUMAN	CDC27	physical	15280373
TBG1_HUMAN	TUBG1	physical	15280373

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.