HHEX_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HHEX_HUMAN
• UniProt AC: Q03014
• Protein Name: Hematopoietically-expressed homeobox protein HHEX
• Gene Name: HHEX
• Organism: Homo sapiens (Human).
• Sequence Length: 270
• Subcellular Localization: Nucleus .
• Protein Description: Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity)..
• Protein Sequence: MQYPHPGPAAGAVGVPLYAPTPLLQPAHPTPFYIEDILGRGPAAPTPAPTLPSPNSSFTSLVSPYRTPVYEPTPIHPAFSHHSAAALAAAYGPGGFGGPLYPFPRTVNDYTHALLRHDPLGKPLLWSPFLQRPLHKRKGGQVRFSNDQTIELEKKFETQKYLSPPERKRLAKMLQLSERQVKTWFQNRRAKWRRLKQENPQSNKKEELESLDSSCDQRQDLPSEQNKGASLDSSQCSPSPASQEDLESEISEDSDQEVDIEGDKSYFNAG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	Phosphorylation	TPAPTLPSPNSSFTS CCCCCCCCCCCCCCC	39.56	23186163
122	Ubiquitination	LRHDPLGKPLLWSPF HHCCCCCCCCCCCHH	39.93	21890473
122	Ubiquitination	LRHDPLGKPLLWSPF HHCCCCCCCCCCCHH	39.93	21890473
163	Phosphorylation	FETQKYLSPPERKRL HCHHCCCCHHHHHHH	35.01	25159151
172	Ubiquitination	PERKRLAKMLQLSER HHHHHHHHHHHHHHH	44.74	33845483
177	Phosphorylation	LAKMLQLSERQVKTW HHHHHHHHHHHHHHH	20.13	19324893
210	Phosphorylation	NKKEELESLDSSCDQ CCHHHHHHHHHCCCC	50.53	29116813
213	Phosphorylation	EELESLDSSCDQRQD HHHHHHHHCCCCHHC	37.85	25159151
214	Phosphorylation	ELESLDSSCDQRQDL HHHHHHHCCCCHHCC	22.75	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
163	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
163	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
177	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
177	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HHEX_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HHEX_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KR412_HUMAN	KRTAP4-12	physical	16189514
FBLN4_HUMAN	EFEMP2	physical	16189514
PSA3_HUMAN	PSMA3	physical	12826010
TLE1_HUMAN	TLE1	physical	15187083
TRM6_HUMAN	TRMT6	physical	21988832
KR107_HUMAN	KRTAP10-7	physical	25416956
KR108_HUMAN	KRTAP10-8	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.