FBLN4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBLN4_HUMAN
• UniProt AC: O95967
• Protein Name: EGF-containing fibulin-like extracellular matrix protein 2
• Gene Name: EFEMP2
• Organism: Homo sapiens (Human).
• Sequence Length: 443
• Subcellular Localization: Secreted.
• Protein Sequence: MLPCASCLPGSLLLWALLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCINEPGRFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCLCPASNPLCREQPSSIVHRYMTITSERSVPADVFQIQATSVYPGAYNAFQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTMNSLMSYRASSVLRLTVFVGAYTF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
137	Phosphorylation	ALHDCRPSQDCHNLP HHHHCCCCCCCCCCC	21.21	24043423
146	Phosphorylation	DCHNLPGSYQCTCPD CCCCCCCCCEEECCC	15.30	24043423
147	Phosphorylation	CHNLPGSYQCTCPDG CCCCCCCCEEECCCC	17.33	24043423
150	Phosphorylation	LPGSYQCTCPDGYRK CCCCCEEECCCCCHH	16.14	24043423
155	Phosphorylation	QCTCPDGYRKIGPEC EEECCCCCHHCCCCE	19.00	24043423
183	Phosphorylation	RCVNLPGSFRCQCEP CCCCCCCCEEEEECC	13.95	25690035
198	N-linked_Glycosylation	GFQLGPNNRSCVDVN CCCCCCCCCCCCCHH	40.14	UniProtKB CARBOHYD
341	Phosphorylation	PLCREQPSSIVHRYM CCCCCCCCCCHHEHH	32.18	28348404
342	Phosphorylation	LCREQPSSIVHRYMT CCCCCCCCCHHEHHE	35.00	28348404
349	Phosphorylation	SIVHRYMTITSERSV CCHHEHHEECCCCCC	16.51	24719451
351	Phosphorylation	VHRYMTITSERSVPA HHEHHEECCCCCCCC	18.50	28348404
352	Phosphorylation	HRYMTITSERSVPAD HEHHEECCCCCCCCC	27.45	28348404
373	Phosphorylation	TSVYPGAYNAFQIRA EEECCCCCEEEEEEC	16.97	-
394	N-linked_Glycosylation	FYIRQINNVSAMLVL EEEEEECCEEEEEEE	30.65	UniProtKB CARBOHYD
426	Phosphorylation	TMNSLMSYRASSVLR EHHHHHHHHHHHHHH	9.02	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FBLN4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBLN4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBLN4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PLS4_HUMAN	PLSCR4	physical	16189514
SGTB_HUMAN	SGTB	physical	16189514
CTSR1_HUMAN	CATSPER1	physical	16189514
PIDD1_HUMAN	PIDD1	physical	16189514
LIGO1_HUMAN	LINGO1	physical	16189514
F124B_HUMAN	FAM124B	physical	16189514
ZN426_HUMAN	ZNF426	physical	16189514
RHPN1_HUMAN	RHPN1	physical	16189514
RHXF2_HUMAN	RHOXF2	physical	16189514
SGTB_HUMAN	SGTB	physical	25416956
NUFP2_HUMAN	NUFIP2	physical	25416956
CCD33_HUMAN	CCDC33	physical	25416956
CE024_HUMAN	C5orf24	physical	25416956
LCE2D_HUMAN	LCE2D	physical	25416956
LCE3C_HUMAN	LCE3C	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 614437: Cutis laxa, autosomal recessive, 1B (ARCL1B)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.