RHPN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RHPN1_HUMAN
• UniProt AC: Q8TCX5
• Protein Name: Rhophilin-1
• Gene Name: RHPN1
• Organism: Homo sapiens (Human).
• Sequence Length: 695
• Protein Description: Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component upon Rho binding or relay a Rho signal to other molecules (By similarity)..
• Protein Sequence: MILEERPDGAGAGEESPRLQGCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENLYRATSNNRVRETVALELSYVNSNLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETKELDWSTPLKELISVHFGEDGASYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFLDARFLTPARSLGLFFHWYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQDRSCTEGARRAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCALEQLMMAQAQECVFEGLSPPASMAPQDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFRSLAHYHVAMALCDGSRECPPHLPMVLPRPPRAGSQPLCPPAATEGELPTHEQVFLQPPTSSKPRGPVLPQELEERRQLGKAHLKRAILGQEEALRLHALCRVLREVDLLRAVISQTLQRSLAKYAELDREDDFCEAAEAPDIQPKTHQKPEARMPRLSQGKGPDIFHRLGPLSVFSAKNRWRLVGPVHLTRGEGGFGLTLRGDSPVLIAAVIPGSQAAAAGLKEGDYIVSVNGQPCRWWRHAEVVTELKAAGEAGASLQVVSLLPSSRLPSLGDRRPVLLGPRGLLRSQREHGCKTPASTWASPRPLLNWSRKAQQGKTGGCPQPCAPVKPAPPSSLKHPGWP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	GAGAGEESPRLQGCD CCCCCCCCCCCCCCC	15.83	30266825
24	Phosphorylation	PRLQGCDSLTQIQCG CCCCCCCCCCCHHCH	37.08	27251275
26	Phosphorylation	LQGCDSLTQIQCGQL CCCCCCCCCHHCHHH	27.81	27251275
92	Phosphorylation	KEELEELSGGVDPGR HHHHHHHCCCCCCCC	36.46	-
118	Ubiquitination	PLGLKETKELDWSTP CCCCCCCCCCCCCCC	58.32	29967540
157	Phosphorylation	ALRQAMRTPSRNESG HHHHHHCCCCCCHHH	16.72	-
159	Phosphorylation	RQAMRTPSRNESGLE HHHHCCCCCCHHHHH	47.31	-
163	Phosphorylation	RTPSRNESGLELLTA CCCCCCHHHHHHHHH	52.83	-
188	Phosphorylation	RFLTPARSLGLFFHW HCCCCHHHHCCHHHH	28.97	27251275
436	Acetylation	QLGKAHLKRAILGQE HHHHHHHHHHHCCHH	29.89	7589111
450	Ubiquitination	EEALRLHALCRVLRE HHHHHHHHHHHHHHH	16.98	-
475	Ubiquitination	TLQRSLAKYAELDRE HHHHHHHHHHHCCCC	50.73	-
498	Phosphorylation	APDIQPKTHQKPEAR CCCCCCCCCCCCCCC	35.90	26074081
505	Ubiquitination	THQKPEARMPRLSQG CCCCCCCCCCCHHCC	33.70	-
510	Phosphorylation	EARMPRLSQGKGPDI CCCCCCHHCCCCCCH	37.86	26074081
530	Ubiquitination	PLSVFSAKNRWRLVG CCEEEECCCCEEEEC	45.94	-
609	Phosphorylation	AAGEAGASLQVVSLL HHHHCCCCEEEEECC	20.58	27732954
614	Phosphorylation	GASLQVVSLLPSSRL CCCEEEEECCCCCCC	25.90	27732954
618	Phosphorylation	QVVSLLPSSRLPSLG EEEECCCCCCCCCCC	28.23	27732954
619	Phosphorylation	VVSLLPSSRLPSLGD EEECCCCCCCCCCCC	35.58	27732954
632	Methylation	GDRRPVLLGPRGLLR CCCCCCCCCHHHHHH	10.13	-
655	Phosphorylation	TPASTWASPRPLLNW CCCCCCCCCCCCCCC	17.01	28509920
657	Dimethylation	ASTWASPRPLLNWSR CCCCCCCCCCCCCHH	31.81	-
657	Methylation	ASTWASPRPLLNWSR CCCCCCCCCCCCCHH	31.81	54561735
663	Phosphorylation	PRPLLNWSRKAQQGK CCCCCCCHHHHHCCC	23.88	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RHPN1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RHPN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RHPN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CNKR1_HUMAN	CNKSR1	physical	14749388
CEP70_HUMAN	CEP70	physical	21516116
PTN14_HUMAN	PTPN14	physical	28514442
PTN21_HUMAN	PTPN21	physical	28514442
KIBRA_HUMAN	WWC1	physical	28514442
WWC2_HUMAN	WWC2	physical	28514442
GOGA2_HUMAN	GOLGA2	physical	28514442
KLH11_HUMAN	KLHL11	physical	28514442
PDXL2_HUMAN	PODXL2	physical	28514442
TTC19_HUMAN	TTC19	physical	28514442
PODXL_HUMAN	PODXL	physical	28514442
ZBT10_HUMAN	ZBTB10	physical	28514442
SNTB2_HUMAN	SNTB2	physical	28514442
CTNL1_HUMAN	CTNNAL1	physical	28514442
MELK_HUMAN	MELK	physical	28514442
NDUB9_HUMAN	NDUFB9	physical	28514442
DTNB_HUMAN	DTNB	physical	28514442
MK09_HUMAN	MAPK9	physical	28514442
UBP15_HUMAN	USP15	physical	28514442
SPAG5_HUMAN	SPAG5	physical	28514442
UTRO_HUMAN	UTRN	physical	28514442
MCMBP_HUMAN	MCMBP	physical	28514442
LZTS2_HUMAN	LZTS2	physical	28514442
UBP47_HUMAN	USP47	physical	28514442
IFT81_HUMAN	IFT81	physical	28514442
PPCE_HUMAN	PREP	physical	28514442
MTMR4_HUMAN	MTMR4	physical	28514442
WDR47_HUMAN	WDR47	physical	28514442
IFT74_HUMAN	IFT74	physical	28514442
P4R3A_HUMAN	SMEK1	physical	28514442
GORS1_HUMAN	GORASP1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.