KLH11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLH11_HUMAN
• UniProt AC: Q9NVR0
• Protein Name: Kelch-like protein 11
• Gene Name: KLHL11
• Organism: Homo sapiens (Human).
• Sequence Length: 708
• Protein Description: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation..
• Protein Sequence: MAAAAVAAAAAAAAAASLQVLEMESMETAAAGSAGLAAEVRGSGTVDFGPGPGISAMEASGGDPGPEAEDFECSSHCSELSWRQNEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWSSEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELADRFLLIRLKEFCGEFLKKKLHLSNCVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQDEEFYTLPFHLIRDWLSDLEITVDSEEVLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPTYLTRHVKPERLVANNEVCVKLVADAVERHALRAENIQSGTCQHPTSHVSLLPRYGQNMDVIMVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEPGFAKTVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDKWHNLESAPKILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAVITCYDTETRQWQDVESLPLIDNYCFFQMSVVNSNFYQTASCCPKSYCLENEEAVRKIASQVSDEILESLPPEVLSIEGAAICYYKDDVFIIGGWKNSDDIDKQYRKEAYRYCAERKRWMLLPPMPQPRCRATACHVRIPYRYLHGTQRYPMPQNLMWQKDRIRQMQEIHRHALNMRRVPSSQIEC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
81	Phosphorylation	SSHCSELSWRQNEQR CHHHHHCHHHHHHHH	19.03	24719451
113	Phosphorylation	REFRAHRSVLAAATE HHHHHHHHHHHHHHH	16.18	-
121	Phosphorylation	VLAAATEYFTPLLSG HHHHHHHHHHHHHCC	14.38	22817900
123	Phosphorylation	AAATEYFTPLLSGQF HHHHHHHHHHHCCCC	16.48	26074081
127	Phosphorylation	EYFTPLLSGQFSESR HHHHHHHCCCCCCCC	37.93	26074081
142	Ubiquitination	SGRVEMRKWSSEPGP CCCCEEEEECCCCCC	50.55	-
189	Ubiquitination	RFLLIRLKEFCGEFL HHHHHHHHHHHHHHH	38.61	-
197	Ubiquitination	EFCGEFLKKKLHLSN HHHHHHHHHHHHHHH	53.86	-
234	Ubiquitination	MIRRNFHKVIQDEEF HHHHHHHHHHCCCCH	36.57	21906983
290	Ubiquitination	RYFEELFKLLRLSQM HHHHHHHHHHHHHHC	60.27	-
298	Ubiquitination	LLRLSQMKPTYLTRH HHHHHHCCCCCHHCC	26.94	21906983
300	Phosphorylation	RLSQMKPTYLTRHVK HHHHCCCCCHHCCCC	26.16	-
307	Ubiquitination	TYLTRHVKPERLVAN CCHHCCCCHHHEECC	34.73	-
320	Ubiquitination	ANNEVCVKLVADAVE CCCHHHHHHHHHHHH	31.92	21890473
443	Ubiquitination	VCSLMTRKHSFGLTE HHHHHHCCCCCCCEE	34.14	-
445	Phosphorylation	SLMTRKHSFGLTEVK HHHHCCCCCCCEEEE	24.84	20873877
449	Phosphorylation	RKHSFGLTEVKGKLY CCCCCCCEEEECEEE	38.83	20873877
452	Ubiquitination	SFGLTEVKGKLYSIG CCCCEEEECEEEEEC	44.06	21906983
454	Ubiquitination	GLTEVKGKLYSIGGH CCEEEECEEEEECCC	38.24	21906983
465	Phosphorylation	IGGHGNFSPGFKDVT ECCCCCCCCCCCEEE	28.28	25159151
469	Ubiquitination	GNFSPGFKDVTVYNP CCCCCCCCEEEEECC	58.15	21906983
480	Ubiquitination	VYNPELDKWHNLESA EECCCHHHCCCCCHH	64.08	21906983
486	Phosphorylation	DKWHNLESAPKILRD HHCCCCCHHHHHHHH	53.70	-
489	Ubiquitination	HNLESAPKILRDVKA CCCCHHHHHHHHHHH	54.83	21906983
495	Ubiquitination	PKILRDVKALAIEDR HHHHHHHHHHHCCCC	41.81	21906983
521	Ubiquitination	RDTEDGLKAVITCYD CCCCCCEEEEEEEEE	46.25	21890473
618	Ubiquitination	VFIIGGWKNSDDIDK EEEEECCCCHHHHHH	50.26	-
620	Phosphorylation	IIGGWKNSDDIDKQY EEECCCCHHHHHHHH	32.69	-
625	Ubiquitination	KNSDDIDKQYRKEAY CCHHHHHHHHHHHHH	49.95	21906983
672	Phosphorylation	YLHGTQRYPMPQNLM HCCCCCCCCCCCCHH	8.28	29632367
682	Ubiquitination	PQNLMWQKDRIRQMQ CCCHHCHHHHHHHHH	33.20	21906983
703	Phosphorylation	LNMRRVPSSQIEC-- HHHCCCCHHHCCC--	31.83	23312004
704	Phosphorylation	NMRRVPSSQIEC--- HHCCCCHHHCCC---	29.16	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLH11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLH11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLH11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUL3_HUMAN	CUL3	physical	23349464

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.