PODXL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PODXL_HUMAN
• UniProt AC: O00592
• Protein Name: Podocalyxin
• Gene Name: PODXL
• Organism: Homo sapiens (Human).
• Sequence Length: 558
• Subcellular Localization: Apical cell membrane. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, ruffle. Cell projection, microvillus. Membrane raft. Membrane ; Single-pass type I membrane protein . In single attached epithelial cells is restricte
• Protein Description: Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells..
• Protein Sequence: MRCALALSALLLLLSTPPLLPSSPSPSPSPSQNATQTTTDSSNKTAPTPASSVTIMATDTAQQSTVPTSKANEILASVKATTLGVSSDSPGTTTLAQQVSGPVNTTVARGGGSGNPTTTIESPKSTKSADTTTVATSTATAKPNTTSSQNGAEDTTNSGGKSSHSVTTDLTSTKAEHLTTPHPTSPLSPRQPTSTHPVATPTSSGHDHLMKISSSSSTVAIPGYTFTSPGMTTTLLETVFHHVSQAGLELLTSGDLPTLASQSAGITASSVISQRTQQTSSQMPASSTAPSSQETVQPTSPATALRTPTLPETMSSSPTAASTTHRYPKTPSPTVAHESNWAKCEDLETQTQSEKQLVLNLTGNTLCAGGASDEKLISLICRAVKATFNPAQDKCGIRLASVPGSQTVVVKEITIHTKLPAKDVYERLKDKWDELKEAGVSDMKLGDQGPPEEAEDRFSMPLIITIVCMASFLLLVAALYGCCHQRLSQRKDQQRLTEELQTVENGYHDNPTLEVMETSSEMQEKKVVSLNGELGDSWIVPLDNLTKDDLDEEEDTHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	N-linked_Glycosylation	PSPSPSQNATQTTTD CCCCCCCCCCCCCCC	49.66	UniProtKB CARBOHYD
41	Phosphorylation	ATQTTTDSSNKTAPT CCCCCCCCCCCCCCC	33.45	24260401
43	N-linked_Glycosylation	QTTTDSSNKTAPTPA CCCCCCCCCCCCCCC	50.04	UniProtKB CARBOHYD
45	Phosphorylation	TTDSSNKTAPTPASS CCCCCCCCCCCCCCE	41.96	20860994
48	Phosphorylation	SSNKTAPTPASSVTI CCCCCCCCCCCEEEE	29.08	20860994
58	O-linked_Glycosylation	SSVTIMATDTAQQST CEEEEEEECCCCCCC	19.26	OGP
60	Phosphorylation	VTIMATDTAQQSTVP EEEEEECCCCCCCCC	23.24	-
68	O-linked_Glycosylation	AQQSTVPTSKANEIL CCCCCCCCCHHHHHH	38.22	OGP
69	Phosphorylation	QQSTVPTSKANEILA CCCCCCCCHHHHHHH	24.57	20860994
104	N-linked_Glycosylation	QQVSGPVNTTVARGG EEECCCCCCEEECCC	32.92	UniProtKB CARBOHYD
117	O-linked_Glycosylation	GGGSGNPTTTIESPK CCCCCCCCCEEECCC	40.34	55832239
117	Phosphorylation	GGGSGNPTTTIESPK CCCCCCCCCEEECCC	40.34	-
118	O-linked_Glycosylation	GGSGNPTTTIESPKS CCCCCCCCEEECCCC	27.34	55832243
118	Phosphorylation	GGSGNPTTTIESPKS CCCCCCCCEEECCCC	27.34	-
119	O-linked_Glycosylation	GSGNPTTTIESPKST CCCCCCCEEECCCCC	25.81	55832247
119	Phosphorylation	GSGNPTTTIESPKST CCCCCCCEEECCCCC	25.81	29396449
122	Phosphorylation	NPTTTIESPKSTKSA CCCCEEECCCCCCCC	33.50	25159151
125	O-linked_Glycosylation	TTIESPKSTKSADTT CEEECCCCCCCCCCE	44.44	55832253
125	Phosphorylation	TTIESPKSTKSADTT CEEECCCCCCCCCCE	44.44	-
126	O-linked_Glycosylation	TIESPKSTKSADTTT EEECCCCCCCCCCEE	34.83	55832257
126	Phosphorylation	TIESPKSTKSADTTT EEECCCCCCCCCCEE	34.83	-
128	Phosphorylation	ESPKSTKSADTTTVA ECCCCCCCCCCEEEE	31.31	-
133	Phosphorylation	TKSADTTTVATSTAT CCCCCCEEEEEEEEE	15.38	22210691
140	Phosphorylation	TVATSTATAKPNTTS EEEEEEEECCCCCCC	34.99	22210691
144	N-linked_Glycosylation	STATAKPNTTSSQNG EEEECCCCCCCCCCC	56.11	UniProtKB CARBOHYD
155	Phosphorylation	SQNGAEDTTNSGGKS CCCCCCCCCCCCCCC	21.27	30576142
156	Phosphorylation	QNGAEDTTNSGGKSS CCCCCCCCCCCCCCC	39.44	30576142
158	Phosphorylation	GAEDTTNSGGKSSHS CCCCCCCCCCCCCCC	46.99	30576142
162	O-linked_Glycosylation	TTNSGGKSSHSVTTD CCCCCCCCCCCEEEC	36.24	55832167
163	O-linked_Glycosylation	TNSGGKSSHSVTTDL CCCCCCCCCCEEECC	24.22	55832173
163	Phosphorylation	TNSGGKSSHSVTTDL CCCCCCCCCCEEECC	24.22	24114839
165	O-linked_Glycosylation	SGGKSSHSVTTDLTS CCCCCCCCEEECCCC	24.09	OGP
165	Phosphorylation	SGGKSSHSVTTDLTS CCCCCCCCEEECCCC	24.09	24114839
167	O-linked_Glycosylation	GKSSHSVTTDLTSTK CCCCCCEEECCCCCC	20.01	55832177
168	O-linked_Glycosylation	KSSHSVTTDLTSTKA CCCCCEEECCCCCCH	27.19	55832183
171	O-linked_Glycosylation	HSVTTDLTSTKAEHL CCEEECCCCCCHHHC	36.84	55832189
172	O-linked_Glycosylation	SVTTDLTSTKAEHLT CEEECCCCCCHHHCC	34.90	55832195
173	O-linked_Glycosylation	VTTDLTSTKAEHLTT EEECCCCCCHHHCCC	29.10	55832199
179	O-linked_Glycosylation	STKAEHLTTPHPTSP CCCHHHCCCCCCCCC	39.94	55834547
179	Phosphorylation	STKAEHLTTPHPTSP CCCHHHCCCCCCCCC	39.94	-
180	O-linked_Glycosylation	TKAEHLTTPHPTSPL CCHHHCCCCCCCCCC	26.43	55834551
180	Phosphorylation	TKAEHLTTPHPTSPL CCHHHCCCCCCCCCC	26.43	-
184	O-linked_Glycosylation	HLTTPHPTSPLSPRQ HCCCCCCCCCCCCCC	39.69	55834555
184	Phosphorylation	HLTTPHPTSPLSPRQ HCCCCCCCCCCCCCC	39.69	-
185	O-linked_Glycosylation	LTTPHPTSPLSPRQP CCCCCCCCCCCCCCC	28.44	72264153
185	Phosphorylation	LTTPHPTSPLSPRQP CCCCCCCCCCCCCCC	28.44	25159151
188	O-linked_Glycosylation	PHPTSPLSPRQPTST CCCCCCCCCCCCCCC	22.78	72335461
188	Phosphorylation	PHPTSPLSPRQPTST CCCCCCCCCCCCCCC	22.78	25159151
193	O-linked_Glycosylation	PLSPRQPTSTHPVAT CCCCCCCCCCCCCCC	37.61	50611417
193	Phosphorylation	PLSPRQPTSTHPVAT CCCCCCCCCCCCCCC	37.61	-
194	O-linked_Glycosylation	LSPRQPTSTHPVATP CCCCCCCCCCCCCCC	31.25	50611421
194	Phosphorylation	LSPRQPTSTHPVATP CCCCCCCCCCCCCCC	31.25	-
195	O-linked_Glycosylation	SPRQPTSTHPVATPT CCCCCCCCCCCCCCC	32.45	50611425
195	Phosphorylation	SPRQPTSTHPVATPT CCCCCCCCCCCCCCC	32.45	-
200	O-linked_Glycosylation	TSTHPVATPTSSGHD CCCCCCCCCCCCCCC	27.60	55831827
200	Phosphorylation	TSTHPVATPTSSGHD CCCCCCCCCCCCCCC	27.60	-
202	O-linked_Glycosylation	THPVATPTSSGHDHL CCCCCCCCCCCCCEE	31.04	55831831
202	Phosphorylation	THPVATPTSSGHDHL CCCCCCCCCCCCCEE	31.04	-
203	O-linked_Glycosylation	HPVATPTSSGHDHLM CCCCCCCCCCCCEEE	35.21	55831837
204	O-linked_Glycosylation	PVATPTSSGHDHLMK CCCCCCCCCCCEEEE	42.50	55831841
232	O-linked_Glycosylation	TFTSPGMTTTLLETV EEECCCCCHHHHHHH	23.65	OGP
261	O-linked_Glycosylation	GDLPTLASQSAGITA CCCCCHHHCCCCCCH	27.99	OGP
267	O-linked_Glycosylation	ASQSAGITASSVISQ HHCCCCCCHHHHHHH	21.40	OGP
267	Phosphorylation	ASQSAGITASSVISQ HHCCCCCCHHHHHHH	21.40	20068231
269	O-linked_Glycosylation	QSAGITASSVISQRT CCCCCCHHHHHHHHH	19.25	OGP
276	Phosphorylation	SSVISQRTQQTSSQM HHHHHHHHCCCCCCC	19.86	20068231
279	Phosphorylation	ISQRTQQTSSQMPAS HHHHHCCCCCCCCCC	22.11	20068231
280	Phosphorylation	SQRTQQTSSQMPASS HHHHCCCCCCCCCCC	17.78	20068231
281	Phosphorylation	QRTQQTSSQMPASST HHHCCCCCCCCCCCC	33.61	20068231
286	Phosphorylation	TSSQMPASSTAPSSQ CCCCCCCCCCCCCCC	23.50	20068231
287	Phosphorylation	SSQMPASSTAPSSQE CCCCCCCCCCCCCCC	30.60	20068231
288	Phosphorylation	SQMPASSTAPSSQET CCCCCCCCCCCCCCC	39.84	20068231
291	Phosphorylation	PASSTAPSSQETVQP CCCCCCCCCCCCCCC	42.04	20068231
292	Phosphorylation	ASSTAPSSQETVQPT CCCCCCCCCCCCCCC	30.86	20068231
295	O-linked_Glycosylation	TAPSSQETVQPTSPA CCCCCCCCCCCCCCC	19.46	OGP
295	Phosphorylation	TAPSSQETVQPTSPA CCCCCCCCCCCCCCC	19.46	20068231
299	O-linked_Glycosylation	SQETVQPTSPATALR CCCCCCCCCCCHHCC	30.19	OGP
299	Phosphorylation	SQETVQPTSPATALR CCCCCCCCCCCHHCC	30.19	20068231
300	Phosphorylation	QETVQPTSPATALRT CCCCCCCCCCHHCCC	21.15	20068231
303	Phosphorylation	VQPTSPATALRTPTL CCCCCCCHHCCCCCC	29.61	20068231
307	O-linked_Glycosylation	SPATALRTPTLPETM CCCHHCCCCCCCCHH	22.83	55824051
309	O-linked_Glycosylation	ATALRTPTLPETMSS CHHCCCCCCCCHHCC	55.09	55824057
309	Phosphorylation	ATALRTPTLPETMSS CHHCCCCCCCCHHCC	55.09	-
315	O-linked_Glycosylation	PTLPETMSSSPTAAS CCCCCHHCCCCCCCC	34.77	46267497
315	Phosphorylation	PTLPETMSSSPTAAS CCCCCHHCCCCCCCC	34.77	-
316	O-linked_Glycosylation	TLPETMSSSPTAAST CCCCHHCCCCCCCCC	29.52	55824067
316	Phosphorylation	TLPETMSSSPTAAST CCCCHHCCCCCCCCC	29.52	-
317	O-linked_Glycosylation	LPETMSSSPTAASTT CCCHHCCCCCCCCCC	20.97	46267501
317	Phosphorylation	LPETMSSSPTAASTT CCCHHCCCCCCCCCC	20.97	-
319	O-linked_Glycosylation	ETMSSSPTAASTTHR CHHCCCCCCCCCCCC	36.48	55824077
319	Phosphorylation	ETMSSSPTAASTTHR CHHCCCCCCCCCCCC	36.48	-
322	O-linked_Glycosylation	SSSPTAASTTHRYPK CCCCCCCCCCCCCCC	31.23	55824081
322	Phosphorylation	SSSPTAASTTHRYPK CCCCCCCCCCCCCCC	31.23	-
323	O-linked_Glycosylation	SSPTAASTTHRYPKT CCCCCCCCCCCCCCC	23.15	55824085
323	Phosphorylation	SSPTAASTTHRYPKT CCCCCCCCCCCCCCC	23.15	-
324	O-linked_Glycosylation	SPTAASTTHRYPKTP CCCCCCCCCCCCCCC	11.23	55824089
324	Phosphorylation	SPTAASTTHRYPKTP CCCCCCCCCCCCCCC	11.23	-
330	O-linked_Glycosylation	TTHRYPKTPSPTVAH CCCCCCCCCCCCCCC	25.21	55825547
332	O-linked_Glycosylation	HRYPKTPSPTVAHES CCCCCCCCCCCCCCC	38.13	55825553
332	Phosphorylation	HRYPKTPSPTVAHES CCCCCCCCCCCCCCC	38.13	24114839
334	O-linked_Glycosylation	YPKTPSPTVAHESNW CCCCCCCCCCCCCCC	34.36	55825559
334	Phosphorylation	YPKTPSPTVAHESNW CCCCCCCCCCCCCCC	34.36	-
339	O-linked_Glycosylation	SPTVAHESNWAKCED CCCCCCCCCCCCCCC	28.01	45660759
339	Phosphorylation	SPTVAHESNWAKCED CCCCCCCCCCCCCCC	28.01	-
344	S-palmitoylation	HESNWAKCEDLETQT CCCCCCCCCCCCCCC	3.67	29575903
360	N-linked_Glycosylation	SEKQLVLNLTGNTLC CCEEEEEECCCCCEE	28.25	UniProtKB CARBOHYD
387	O-linked_Glycosylation	ICRAVKATFNPAQDK HHHHHHHHCCHHHCC	20.44	55831573
401	O-linked_Glycosylation	KCGIRLASVPGSQTV CCCEEEEECCCCEEE	33.18	55825351
405	O-linked_Glycosylation	RLASVPGSQTVVVKE EEEECCCCEEEEEEE	19.33	55825355
407	O-linked_Glycosylation	ASVPGSQTVVVKEIT EECCCCEEEEEEEEE	19.57	55825359
414	O-linked_Glycosylation	TVVVKEITIHTKLPA EEEEEEEEEEECCCH	14.06	55826513
417	O-linked_Glycosylation	VKEITIHTKLPAKDV EEEEEEEECCCHHHH	30.35	55826517
422	Ubiquitination	IHTKLPAKDVYERLK EEECCCHHHHHHHHH	45.87	-
425	Phosphorylation	KLPAKDVYERLKDKW CCCHHHHHHHHHHHH	12.88	28152594
431	Ubiquitination	VYERLKDKWDELKEA HHHHHHHHHHHHHHC	55.76	-
436	2-Hydroxyisobutyrylation	KDKWDELKEAGVSDM HHHHHHHHHCCCCCC	43.39	-
441	Phosphorylation	ELKEAGVSDMKLGDQ HHHHCCCCCCCCCCC	30.94	-
493 (in isoform 2)	Ubiquitination	-	33.07	21890473
494 (in isoform 2)	Ubiquitination	-	53.11	21890473
502	Phosphorylation	RLTEELQTVENGYHD HHHHHHHHHHCCCCC	42.27	27251275
507	Phosphorylation	LQTVENGYHDNPTLE HHHHHCCCCCCCCEE	19.99	27259358
512	Phosphorylation	NGYHDNPTLEVMETS CCCCCCCCEEEEECC	41.63	23663014
515 (in isoform 2)	Ubiquitination	-	4.77	-
518	Phosphorylation	PTLEVMETSSEMQEK CCEEEEECCHHHHHC	21.32	30266825
519	Phosphorylation	TLEVMETSSEMQEKK CEEEEECCHHHHHCE	15.82	30266825
520	Phosphorylation	LEVMETSSEMQEKKV EEEEECCHHHHHCEE	44.50	30266825
525	Ubiquitination	TSSEMQEKKVVSLNG CCHHHHHCEEEEECC	33.70	21906983
526	Ubiquitination	SSEMQEKKVVSLNGE CHHHHHCEEEEECCC	47.30	21890473
527 (in isoform 1)	Ubiquitination	-	5.39	21890473
528 (in isoform 1)	Ubiquitination	-	8.06	21890473
529	Phosphorylation	MQEKKVVSLNGELGD HHHCEEEEECCCCCC	21.07	25159151
537	Phosphorylation	LNGELGDSWIVPLDN ECCCCCCEEEEECHH	19.53	19664994
546	Phosphorylation	IVPLDNLTKDDLDEE EEECHHCCHHHCCHH	38.39	22777824
547	Ubiquitination	VPLDNLTKDDLDEEE EECHHCCHHHCCHHH	53.03	-
556	Phosphorylation	DLDEEEDTHL----- HCCHHHCCCC-----	28.49	9188463

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PODXL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PODXL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PODXL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NHRF2_HUMAN	SLC9A3R2	physical	15642748
NHRF2_HUMAN	SLC9A3R2	physical	11457882
HS12A_HUMAN	HSPA12A	physical	28514442
IMDH1_HUMAN	IMPDH1	physical	28514442
HS12B_HUMAN	HSPA12B	physical	28514442
JIP4_HUMAN	SPAG9	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.