HS12B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HS12B_HUMAN
• UniProt AC: Q96MM6
• Protein Name: Heat shock 70 kDa protein 12B
• Gene Name: HSPA12B
• Organism: Homo sapiens (Human).
• Sequence Length: 686
• Protein Sequence: MLAVPEMGLQGLYIGSSPERSPVPSPPGSPRTQESCGIAPLTPSQSPKPEVRAPQQASFSVVVAIDFGTTSSGYAFSFASDPEAIHMMRKWEGGDPGVAHQKTPTCLLLTPEGAFHSFGYTARDYYHDLDPEEARDWLYFEKFKMKIHSATDLTLKTQLEAVNGKTMPALEVFAHALRFFREHALQELREQSPSLPEKDTVRWVLTVPAIWKQPAKQFMREAAYLAGLVSRENAEQLLIALEPEAASVYCRKLRLHQLLDLSGRAPGGGRLGERRSIDSSFRQAREQLRRSRHSRTFLVESGVGELWAEMQAGDRYVVADCGGGTVDLTVHQLEQPHGTLKELYKASGGPYGAVGVDLAFEQLLCRIFGEDFIATFKRQRPAAWVDLTIAFEARKRTAGPHRAGALNISLPFSFIDFYRKQRGHNVETALRRSSVNFVKWSSQGMLRMSCEAMNELFQPTVSGIIQHIEALLARPEVQGVKLLFLVGGFAESAVLQHAVQAALGARGLRVVVPHDVGLTILKGAVLFGQAPGVVRVRRSPLTYGVGVLNRFVPGRHPPEKLLVRDGRRWCTDVFERFVAAEQSVALGEEVRRSYCPARPGQRRVLINLYCCAAEDARFITDPGVRKCGALSLELEPADCGQDTAGAPPGRREIRAAMQFGDTEIKVTAVDVSTNRSVRASIDFLSN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	EMGLQGLYIGSSPER CCCCCEEECCCCCCC	15.29	24043423
16	Phosphorylation	LQGLYIGSSPERSPV CCEEECCCCCCCCCC	32.91	28857561
17	Phosphorylation	QGLYIGSSPERSPVP CEEECCCCCCCCCCC	26.10	28857561
21	Phosphorylation	IGSSPERSPVPSPPG CCCCCCCCCCCCCCC	28.70	26657352
25	Phosphorylation	PERSPVPSPPGSPRT CCCCCCCCCCCCCCC	43.92	24670416
29	Phosphorylation	PVPSPPGSPRTQESC CCCCCCCCCCCCCCC	19.58	23911959
32	Phosphorylation	SPPGSPRTQESCGIA CCCCCCCCCCCCCCC	39.82	23403867
35	Phosphorylation	GSPRTQESCGIAPLT CCCCCCCCCCCCCCC	14.07	23403867
42	Phosphorylation	SCGIAPLTPSQSPKP CCCCCCCCCCCCCCC	21.60	26657352
44	Phosphorylation	GIAPLTPSQSPKPEV CCCCCCCCCCCCCCC	37.75	26657352
46	Phosphorylation	APLTPSQSPKPEVRA CCCCCCCCCCCCCCC	38.95	23911959
200	Phosphorylation	PSLPEKDTVRWVLTV CCCCCCCCEEEEEEH	24.04	-
206	Phosphorylation	DTVRWVLTVPAIWKQ CCEEEEEEHHHHHCC	18.15	-
262	Phosphorylation	LHQLLDLSGRAPGGG HHHHHHHCCCCCCCC	26.37	-
276	Phosphorylation	GRLGERRSIDSSFRQ CCCCCCCCCCHHHHH	36.65	23911959
279	Phosphorylation	GERRSIDSSFRQARE CCCCCCCHHHHHHHH	29.70	23403867
280	Phosphorylation	ERRSIDSSFRQAREQ CCCCCCHHHHHHHHH	22.24	24702127
397	Phosphorylation	AFEARKRTAGPHRAG EHHHHHCCCCCCCCC	38.71	-
433	Phosphorylation	VETALRRSSVNFVKW HHHHHHHHCCCEEEE	32.00	23663014
434	Phosphorylation	ETALRRSSVNFVKWS HHHHHHHCCCEEEEC	21.19	23663014
442	Phosphorylation	VNFVKWSSQGMLRMS CCEEEECCHHHHHHH	29.64	28857561
662	Phosphorylation	AAMQFGDTEIKVTAV HHHHHCCCEEEEEEE	39.73	23403867
667	Phosphorylation	GDTEIKVTAVDVSTN CCCEEEEEEEECCCC	18.89	18187866

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HS12B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HS12B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HS12B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
K1C40_HUMAN	KRT40	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-667, AND MASSSPECTROMETRY.
PubMed: 18187866