PLS4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLS4_HUMAN
• UniProt AC: Q9NRQ2
• Protein Name: Phospholipid scramblase 4
• Gene Name: PLSCR4
• Organism: Homo sapiens (Human).
• Sequence Length: 329
• Subcellular Localization: Membrane; Single-pass type II membrane protein.
• Protein Description: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system..
• Protein Sequence: MSGVVPTAPEQPAGEMENQTKPPDPRPDAPPEYNSHFLPGPPGTAVPPPTGYPGGLPMGYYSPQQPSTFPLYQPVGGIHPVRYQPGKYPMPNQSVPITWMPGPTPMANCPPGLEYLVQLDNIHVLQHFEPLEMMTCFETNNRYDIKNNSDQMVYIVTEDTDDFTRNAYRTLRPFVLRVTDCMGREIMTMQRPFRCTCCCFCCPSARQELEVQCPPGVTIGFVAEHWNLCRAVYSIQNEKKENVMRVRGPCSTYGCGSDSVFEVKSLDGISNIGSIIRKWNGLLSAMADADHFDIHFPLDLDVKMKAMIFGACFLIDFMYFERSPPQRSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
83	Phosphorylation	GGIHPVRYQPGKYPM CCCCCCCCCCCCCCC	21.20	14757045
88	Phosphorylation	VRYQPGKYPMPNQSV CCCCCCCCCCCCCCC	15.64	14757045
197	S-palmitoylation	QRPFRCTCCCFCCPS CCCEEEEEECEECCC	1.86	-
198	S-palmitoylation	RPFRCTCCCFCCPSA CCEEEEEECEECCCH	0.78	-
199	S-palmitoylation	PFRCTCCCFCCPSAR CEEEEEECEECCCHH	2.96	-
201	S-palmitoylation	RCTCCCFCCPSARQE EEEEECEECCCHHHH	1.76	-
202	S-palmitoylation	CTCCCFCCPSARQEL EEEECEECCCHHHHH	1.17	-
229	S-palmitoylation	VAEHWNLCRAVYSIQ EHHHHHHHHHHHHHH	2.07	29575903
233	Phosphorylation	WNLCRAVYSIQNEKK HHHHHHHHHHHHCCC	10.08	22817900
234	Phosphorylation	NLCRAVYSIQNEKKE HHHHHHHHHHHCCCC	15.88	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
83	Y	Phosphorylation	Kinase	ABL1	P00519	PhosphoELM
83	Y	Phosphorylation	Kinase	ABL-FAMILY	-	GPS
88	Y	Phosphorylation	Kinase	ABL1	P00519	PhosphoELM
88	Y	Phosphorylation	Kinase	ABL-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLS4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLS4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KR412_HUMAN	KRTAP4-12	physical	16189514
NT2NL_HUMAN	NOTCH2NL	physical	25416956
ZDH17_HUMAN	ZDHHC17	physical	26186194
TLE1_HUMAN	TLE1	physical	26186194
FBLN1_HUMAN	FBLN1	physical	26186194
DPH1_HUMAN	DPH1	physical	26186194
AB17A_HUMAN	ABHD17A	physical	21516116
APEL_HUMAN	APLN	physical	21516116
LPXN_HUMAN	LPXN	physical	21516116
ZDH17_HUMAN	ZDHHC17	physical	28514442
FBLN1_HUMAN	FBLN1	physical	28514442
ALG13_HUMAN	ALG13	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.