| UniProt ID | PIDD1_HUMAN | |
|---|---|---|
| UniProt AC | Q9HB75 | |
| Protein Name | p53-induced death domain-containing protein 1 | |
| Gene Name | PIDD1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 910 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | Promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. Associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. Associates with CASP2/caspase-2 and CRADD/RAIDD, and induces activation of CASP2 which an important regulator in apoptotic pathways.. | |
| Protein Sequence | MAATVEGPELEAAAAAGDASEDSDAGSRALPFLGGNRLSLDLYPGGCQQLLHLCVQQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAPSSPVAALIPEMPRLFLTSDLDSFPVTPQGCSVTLACGVRLQFPAGATATPITIRYRLLLPEPGLVPLGPHDALLSHVLELQPHGVAFQQDVGLWLLFTPPQARRCREVVVRTRNDNSWGDLETYLEEEAPQRLWAHCQVPHFSWFLVVSRPVSNACLVPPEGTLLCSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVSPLLCLSQSGPPSFLQPVTVQLPLPSGITGLSLDRSRLHLLYWAPPAATWDDITAQVVLELTHLYARFQVTHFSWYWLWYTTKNCVGGLARKAWERLRLHRVNLIALQRRRDPEQVLLQCLPRNKVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERGIDVDADRPDCVEGRICFVFYSHLKNVKEVYVTTTLDREAQAVRGQVSFYRGAVPVRVPEEAEAARQRKGADALWMATLPIKLPRLRGSEGPRRGAGLSLAPLNLGDAETGFLTQSNLLSVAGRLGLDWPAVALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWAERQAGQPGAVGLLVQALEQSDRQDVAEEVRAVLELGRRKYQDSIRRMGLAPKDPALPGSSAPQPPEPAQA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MAATVEGPE ------CCCEECCHH | - | ||
| 4 | Phosphorylation | ----MAATVEGPELE ----CCCEECCHHHH | - | ||
| 90 | Phosphorylation | AQLPQSLSCLRSLVL HHHCHHHHHHHHHHH | 24719451 | ||
| 98 | Ubiquitination | CLRSLVLKGGQRRDT HHHHHHHCCCCCCCH | - | ||
| 299 | Phosphorylation | GNPLGEASPDAPSSP CCCCCCCCCCCCCCC | 27080861 | ||
| 304 | Phosphorylation | EASPDAPSSPVAALI CCCCCCCCCCHHHHC | 27080861 | ||
| 305 | Phosphorylation | ASPDAPSSPVAALIP CCCCCCCCCHHHHCC | 27080861 | ||
| 452 | Phosphorylation | FSWFLVVSRPVSNAC CEEEEEEECCCCCCE | 24719451 | ||
| 485 | Phosphorylation | VIFPPGATEEPRRVS EEECCCCCCCCCHHH | 19664995 | ||
| 639 | Ubiquitination | LQCLPRNKVDATLRR HHHCCCCCHHHHHHH | - | ||
| 743 | Ubiquitination | AEAARQRKGADALWM HHHHHHHCCCCCEEE | - | ||
| 788 | Phosphorylation | DAETGFLTQSNLLSV CCCCCCCCHHHHHHH | - | ||
| 814 | Phosphorylation | ALHLGVSYREVQRIR HHHHCCCHHHHHHHH | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 788 | T | Phosphorylation | Kinase | ATM | Q13315 | PSP |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PIDD1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PIDD1_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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