SOX8_HUMAN - dbPTM
SOX8_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SOX8_HUMAN
UniProt AC P57073
Protein Name Transcription factor SOX-8
Gene Name SOX8
Organism Homo sapiens (Human).
Sequence Length 446
Subcellular Localization Nucleus .
Protein Description May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3' (By similarity)..
Protein Sequence MLDMSEARSQPPCSPSGTASSMSHVEDSDSDAPPSPAGSEGLGRAGVAVGGARGDPAEAADERFPACIRDAVSQVLKGYDWSLVPMPVRGGGGGALKAKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLSESEKRPFVEEAERLRVQHKKDHPDYKYQPRRRKSAKAGHSDSDSGAELGPHPGGGAVYKAEAGLGDGHHHGDHTGQTHGPPTPPTTPKTELQQAGAKPELKLEGRRPVDSGRQNIDFSNVDISELSSEVMGTMDAFDVHEFDQYLPLGGPAPPEPGQAYGGAYFHAGASPVWAHKSAPSASASPTETGPPRPHIKTEQPSPGHYGDQPRGSPDYGSCSGQSSATPAAPAGPFAGSQGDYGDLQASSYYGAYPGYAPGLYQYPCFHSPRRPYASPLLNGLALPPAHSPTSHWDQPVYTTLTRP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationLDMSEARSQPPCSPS
CCHHHHHCCCCCCCC		54.8322468782
14PhosphorylationARSQPPCSPSGTASS
HHCCCCCCCCCCCCC		28.0722468782
20PhosphorylationCSPSGTASSMSHVED
CCCCCCCCCCCCCCC		26.8122468782
119UbiquitinationWAQAARRKLADQYPH
HHHHHHHHHHHHCCC		42.3423000965
134UbiquitinationLHNAELSKTLGKLWR
CCHHHHHHHHHHHHH		61.4623000965
138AcetylationELSKTLGKLWRLLSE
HHHHHHHHHHHHHCH		48.257297889
138UbiquitinationELSKTLGKLWRLLSE
HHHHHHHHHHHHHCH		48.2521890473
164UbiquitinationRLRVQHKKDHPDYKY
HHHHHHCCCCCCCCC		60.1823000965
169PhosphorylationHKKDHPDYKYQPRRR
HCCCCCCCCCCCCCC		18.95-
170UbiquitinationKKDHPDYKYQPRRRK
CCCCCCCCCCCCCCC		44.8023000965
184PhosphorylationKSAKAGHSDSDSGAE
CCCCCCCCCCCCCCC		37.5825850435
186PhosphorylationAKAGHSDSDSGAELG
CCCCCCCCCCCCCCC		36.3725850435
188PhosphorylationAGHSDSDSGAELGPH
CCCCCCCCCCCCCCC		43.8025850435
202PhosphorylationHPGGGAVYKAEAGLG
CCCCCEEEEEEECCC		12.16-
218PhosphorylationGHHHGDHTGQTHGPP
CCCCCCCCCCCCCCC		35.4123312004
221PhosphorylationHGDHTGQTHGPPTPP
CCCCCCCCCCCCCCC		30.0923312004
226PhosphorylationGQTHGPPTPPTTPKT
CCCCCCCCCCCCCHH		45.0628348404
229PhosphorylationHGPPTPPTTPKTELQ
CCCCCCCCCCHHHHH		57.8628348404
230PhosphorylationGPPTPPTTPKTELQQ
CCCCCCCCCHHHHHH		28.6728985074
320PhosphorylationSPVWAHKSAPSASAS
CCEEECCCCCCCCCC		35.2323312004
323PhosphorylationWAHKSAPSASASPTE
EECCCCCCCCCCCCC		34.2723312004
325PhosphorylationHKSAPSASASPTETG
CCCCCCCCCCCCCCC		33.3523312004
327PhosphorylationSAPSASASPTETGPP
CCCCCCCCCCCCCCC		29.8423312004
329PhosphorylationPSASASPTETGPPRP
CCCCCCCCCCCCCCC		43.6223312004
331PhosphorylationASASPTETGPPRPHI
CCCCCCCCCCCCCCC		58.4223312004
344PhosphorylationHIKTEQPSPGHYGDQ
CCCCCCCCCCCCCCC		43.1125850435
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
327SPhosphorylationKinaseAURAO14965
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SOX8_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SOX8_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SOX8_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SOX8_HUMAN

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Related Literatures of Post-Translational Modification

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