| UniProt ID | MXI1_HUMAN | |
|---|---|---|
| UniProt AC | P50539 | |
| Protein Name | Max-interacting protein 1 | |
| Gene Name | MXI1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 228 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.. | |
| Protein Sequence | MERVKMINVQRLLEAAEFLERRERECEHGYASSFPSMPSPRLQHSKPPRRLSRAQKHSSGSSNTSTANRSTHNELEKNRRAHLRLCLERLKVLIPLGPDCTRHTTLGLLNKAKAHIKKLEEAERKSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSIGSDEGYSSASVKLSFTS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 39 | Phosphorylation | SSFPSMPSPRLQHSK CCCCCCCCCCCCCCC | 17.63 | - | |
| 52 | Phosphorylation | SKPPRRLSRAQKHSS CCCCCHHCHHHHHCC | 24.61 | 30576142 | |
| 61 | Phosphorylation | AQKHSSGSSNTSTAN HHHHCCCCCCCCCCC | 23.51 | 30576142 | |
| 65 | Phosphorylation | SSGSSNTSTANRSTH CCCCCCCCCCCHHHH | 29.76 | 30576142 | |
| 91 | Ubiquitination | RLCLERLKVLIPLGP HHHHHHHCHHEEECC | 41.01 | - | |
| 99 (in isoform 3) | Phosphorylation | - | 44.62 | 27251275 | |
| 100 (in isoform 3) | Phosphorylation | - | 3.97 | 27251275 | |
| 103 (in isoform 3) | Phosphorylation | - | 12.68 | 27251275 | |
| 106 | Phosphorylation | DCTRHTTLGLLNKAK CCCHHHHHHHHHHHH | 4.84 | 27251275 | |
| 106 (in isoform 3) | Phosphorylation | - | 4.84 | 28450419 | |
| 111 | Ubiquitination | TTLGLLNKAKAHIKK HHHHHHHHHHHHHHH | 51.76 | - | |
| 125 | Ubiquitination | KLEEAERKSQHQLEN HHHHHHHHHHHHHHH | 46.07 | - | |
| 141 | Acetylation | EREQRFLKWRLEQLQ HHHHHHHHHHHHHHC | 27.79 | 19813243 | |
| 158 (in isoform 3) | Ubiquitination | - | 4.39 | - | |
| 160 | Phosphorylation | MERIRMDSIGSTISS HHEEEHHHHCCCCCC | 21.36 | - | |
| 166 | Phosphorylation | DSIGSTISSDRSDSE HHHCCCCCCCCCHHH | 26.69 | 22964224 | |
| 167 | Phosphorylation | SIGSTISSDRSDSER HHCCCCCCCCCHHHC | 32.94 | 22964224 | |
| 170 | Phosphorylation | STISSDRSDSEREEI CCCCCCCCHHHCEEE | 50.94 | 22964224 | |
| 192 (in isoform 3) | Ubiquitination | - | 42.30 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MXI1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MXI1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MXI1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MAX_HUMAN | MAX | physical | 10593926 | |
| MAX_HUMAN | MAX | physical | 9528857 | |
| SMC3_HUMAN | SMC3 | physical | 9528857 | |
| MAX_HUMAN | MAX | physical | 15548375 | |
| A4_HUMAN | APP | physical | 21832049 | |
| CACO2_HUMAN | CALCOCO2 | physical | 25416956 | |
| K1C40_HUMAN | KRT40 | physical | 25416956 | |
| KR107_HUMAN | KRTAP10-7 | physical | 25416956 | |
| KR109_HUMAN | KRTAP10-9 | physical | 25416956 | |
| KR108_HUMAN | KRTAP10-8 | physical | 25416956 | |
| KR103_HUMAN | KRTAP10-3 | physical | 25416956 | |
| NT2NL_HUMAN | NOTCH2NL | physical | 25416956 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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